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Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities

Cells, 2022
Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity.
Anne F. J. Janssen, Sophia Y. Breusegem, Delphine Larrieu   +2 more
doaj   +3 more sources

Mechanotransduction by nuclear envelope tension [PDF]

Nucleus
Mechanotransduction mediated by the tension in lipid membranes is a well-established paradigm. This has been studied largely in the context of the plasma membrane, but recent work shows that it applies also to endomembranes, and specifically to the ...
Sriivatsan G. Rajan, Pere Roca-Cusachs, Philipp Niethammer   +2 more
doaj   +2 more sources

Dynamins maintain nuclear envelope homeostasis and genome stability [PDF]

Nature Communications
The nuclear envelope is a protective barrier for the genome and a mechanotransduction interface between cytoplasm and nucleus, whose malfunction disrupts nucleocytoplasmic transport, compromises DNA repair, accelerates telomere shortening, and promotes ...
Célia Aveleira, Thibaud Martial, Loïc Carrique, Rita Gaspar, Ana Caulino-Rocha, Izaak Myatt, Franz Wendler, Pauline Lascaux, Misha Le Claire, James Bancroft, Carl Smythe, Kristijan Ramadan, Nuno Raimundo, Ira Milosevic   +13 more
doaj   +2 more sources

Nuclear Envelope Dynamics in Dictyostelium Amoebae [PDF]

Cells
In the last decades, the study of many nuclear envelope components in Dictyostelium amoebae has revealed conserved mechanisms of nuclear envelope dynamics that root back unexpectedly deep into the eukaryotic tree of life.
Ralph Gräf, Petros Batsios, Marianne Grafe, Irene Meyer, Kristina Mitic   +4 more
doaj   +2 more sources

Nuclear envelope and chromatin choreography direct cellular differentiation [PDF]

Nucleus
The nuclear envelope plays an indispensable role in the spatiotemporal organization of chromatin and transcriptional regulation during the intricate process of cell differentiation.
Anjitha Nair, Jayati Khanna, Jashan Kler, Rohith Ragesh, Kundan Sengupta   +4 more
doaj   +2 more sources

Emerin is necessary for microtubule-organizing center translocation to the nuclear envelope of muscle cells [PDF]

Cell Death and Disease
During myogenic differentiation, the Microtubule-Organizing Center (MTOC) is relocated to the nuclear envelope by a molecular platform including Linker of Nucleoskeleton and Cytoskeleton (LINC) complex proteins, A Kinase Anchoring Proteins (AKAP9 and ...
Elisabetta Mattioli, Vittoria Cenni, Patrizia Sabatelli, Elisa Schena, Spartaco Santi, Chiara Fiorillo, Claudio Bruno, Antonella Pini, Melania Giannotta, Marco Cavallo, Costantino Errani, Eleonora Cattin, Daniela Benati, Alessandra Recchia, Giovanna Lattanzi   +14 more
doaj   +2 more sources

Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]

The EMBO Journal
Brl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal, Annett Neuner, Azqa Ajmal Khan, Jlenia Vitale, Elmar Schiebel   +4 more
doaj   +2 more sources

Temporal Changes in Nuclear Envelope Permeability during Semi-Closed Mitosis in Dictyostelium Amoebae

Cells, 2023
The Amoebozoan Dictyostelium discoideum exhibits a semi-closed mitosis in which the nuclear membranes remain intact but become permeabilized to allow tubulin and spindle assembly factors to access the nuclear interior.
Kristina Mitic, Irene Meyer, Ralph Gräf, Marianne Grafe   +3 more
doaj   +1 more source

Automated analysis of cell migration and nuclear envelope rupture in confined environments. [PDF]

PLoS ONE, 2018
Recent in vitro and in vivo studies have highlighted the importance of the cell nucleus in governing migration through confined environments. Microfluidic devices that mimic the narrow interstitial spaces of tissues have emerged as important tools to ...
Joshua J Elacqua, Alexandra L McGregor, Jan Lammerding   +2 more
doaj   +1 more source

Recent advances in understanding the biological roles of the plant nuclear envelope

Nucleus, 2020
The functional organization of the plant nuclear envelope is gaining increasing attention through new connections made between nuclear envelope-associated proteins and important plant biological processes.
Norman Reid Groves, Alecia Biel, Morgan Moser, Tyler Mendes, Katelyn Amstutz, Iris Meier   +5 more
doaj   +1 more source