Results 31 to 40 of about 138,282 (260)
Parvoviruses cause nuclear envelope breakdown by activating key enzymes of mitosis. [PDF]
PLoS Pathogens, 2013 Disassembly of the nuclear lamina is essential in mitosis and apoptosis requiring multiple coordinated enzymatic activities in nucleus and cytoplasm. Activation and coordination of the different activities is poorly understood and moreover complicated as
Manvi Porwal +10 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Immunocytochemistry of nuclear domains and Emery-Dreifuss muscular dystrophy pathophysiology
European Journal of Histochemistry, 2009 The present review summarizes recent cytochemical findings on the functional organization of the nuclear domains, with a particular emphasis on the relation between nuclear envelope- associated proteins and chromatin.
NM Maraldi +8 more
doaj +1 more source
The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. [PDF]
PLoS Genetics, 2011 The budding yeast spindle pole body (SPB) is anchored in the nuclear envelope so that it can simultaneously nucleate both nuclear and cytoplasmic microtubules. During SPB duplication, the newly formed SPB is inserted into the nuclear membrane.
Jennifer M Friederichs +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Viruses, 2019 During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm.
Vesa Aho +10 more
doaj +1 more source
LINCing Senescence and Nuclear Envelope Changes
Cells, 2022 The nuclear envelope (NE) has emerged as a nexus for cellular organization, signaling, and survival. Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE’s role in supporting and maintaining a myriad of other functions has ...
Bakhita R. M. Meqbel +4 more
doaj +1 more source
SnapShot: The Nuclear Envelope II
Cell, 2012 Nup160 Nup160 CG4738 NPP-6 Nup120 SPBC3B9.16c Nup120Nup133 Nup133 CG6958 NPP-15 Nup132, Nup131 SPAC1805.04, SPBP35G2.06cNup133Nup107 Nup107 CG6743 NPP-5 Nup107 SPBC428.01c Nup84Nup96 Nup96 CG10198 NPP-10C Nup189C SPAC1486.05 Nup145CNup85 (PCNT1) Nup75 CG5733 NPP-2 Nup-85 SPBC17G9.04c Nup85Seh1 Nup44A CG8722 NPP-18 Seh1 SPAC15F9.02 Seh1Sec13 Sec13 ...
Rothballer Andrea, Kutay Ulrike
openaire +3 more sources
Nuclear envelope remodelling during mitosis
Current Opinion in Cell Biology, 2021 The defining feature of the eukaryotic cell, the nucleus, is bounded by a double envelope. This envelope and the nuclear pores within it play a critical role in separating the genome from the cytoplasm. It also presents cells with a challenge. How are cells to remodel the nuclear compartment boundary during mitosis without compromising nuclear function?
Gautam Dey, Buzz Baum
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source