Results 31 to 40 of about 146,588 (257)
Nuclear Envelope Permeability Barrier as a Fast‐Response Intracellular Mechanostat
Advanced Science, 2019 The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli from the environment.
Victor Shahin +3 more
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Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer
Epigenomes, 2018 Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston +1 more
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Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms
Epigenetics & Chromatin, 2022 The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation in several cell lines including Huh7.
Ya-Hui Chi +5 more
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Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. [PDF]
PLoS ONE, 2015 The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA) at the 8-cell stage nuclei showed a non-uniform ...
Jens Popken +9 more
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Nuclear envelope mechanobiology: linking the nuclear structure and function
Nucleus, 2021 The nucleus, central to cellular activity, relies on both direct mechanical input as well as its molecular transducers to sense external stimuli and respond by regulating intra-nuclear chromatin organization that determines cell function and fate.
Matthew Goelzer +4 more
doaj +1 more source
Viruses and the nuclear envelope
Current Opinion in Cell Biology, 2015 Viruses encounter and manipulate almost all aspects of cell structure and metabolism. The nuclear envelope (NE), with central roles in cell structure and genome function, acts and is usurped in diverse ways by different viruses. It can act as a physical barrier to infection that must be overcome, as a functional barrier that restricts infection by ...
Hennig, T, O'Hare, P
openaire +4 more sources
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Nuclear Envelope: Nuclear Pore Complexity [PDF]
Current Biology, 2005 A new study shows that the filamentous fungus, Aspergillus nidulans, which has a closed mitosis, does not maintain a continuous permeability barrier during mitosis. This work challenges current views of the differences between closed and open mitosis and has implications for understanding mitotic specific changes in the nuclear pore complex and Ran ...
openaire +2 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source