Results 1 to 10 of about 1,109,521 (262)
Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Nucleoskeleton proteins for nuclear dynamics
The Journal of Biochemistry, 2021 AbstractThe eukaryotic nucleus shows organized structures of chromosomes, transcriptional components and their associated proteins. It has been believed that such a dense nuclear environment prevents the formation of a cytoskeleton-like network of protein filaments. However, accumulating evidence suggests that the cell nucleus also possesses structural
Kei Miyamoto, Masahiko Harata
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International Journal of Cell Biology, 2012 Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes.
Masahiro Kumeta +3 more
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Nuclear envelopathies: a complex LINC between nuclear envelope and pathology
Orphanet Journal of Rare Diseases, 2017 Since the identification of the first disease causing mutation in the gene coding for emerin, a transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants have been found in genes encoding for nuclear envelope components ...
Alexandre Janin +4 more
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PLoS Pathogens, 2015 The paramyxovirus matrix (M) protein is a molecular scaffold required for viral morphogenesis and budding at the plasma membrane. Transient nuclear residence of some M proteins hints at non-structural roles.
Mickey Pentecost +10 more
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Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein
Neurobiology of Disease, 2005 Nuclear aggregates of polyglutamine (polyQ)-expanded proteins are associated with a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxias (SCAs).
Lianwu Fu, Ya-sheng Gao, Elizabeth Sztul
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Nuclear export of proteins and RNAs
Current Opinion in Cell Biology, 1997 Our understanding of protein export from the nucleus to the cytoplasm has been advanced recently by the discovery of active, signal-mediated export pathways. Nuclear export signals have been identified in several proteins, the majority of which are RNA-binding proteins.
S, Nakielny, G, Dreyfuss
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Nature Communications, 2020 The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization ...
Krishna C. Mudumbi +9 more
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Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses
Viruses, 2019 Typical viral propagation involves sequential viral entry, uncoating, replication, gene transcription and protein synthesis, and virion assembly and release. Some viral proteins must be transported into host nucleus to facilitate viral propagation, which
Guohui Li +3 more
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The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses
Cells, 2020 The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben +2 more
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