Joint single-cell measurements of nuclear proteins and RNA in vivo. [PDF]
Nat Methods, 2021 Identifying gene-regulatory targets of nuclear proteins in tissues is a challenge. Here we describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a scalable method that measures multiplexed intranuclear protein levels and ...
Chung H +9 more
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Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells [PDF]
eLife, 2023 Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response.
Fang Ke +6 more
doaj +2 more sources
Modeling the transport of nuclear proteins along single skeletal muscle cells. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Skeletal muscle cells are unique among human cells because they contain hundreds of nuclei distributed over large distances within a shared cytoplasm.
Taylor-Weiner H +6 more
europepmc +2 more sources
Nuclear transport proteins: structure, function and disease relevance
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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Fractionation and Extraction of Crude Nuclear Proteins From Arabidopsis Seedlings [PDF]
Bio-Protocol, 2022 The plant nucleus is an important subcellular organelle that contains the genome, ribosomal RNA, and regulatory proteins, and performs a central role in the functioning and metabolism of the cell.
Jiajia Zhao, Jinsong Bao, Feifei Xu
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Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. [PDF]
Nat Chem Biol, 2019 Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a limited number of E3 ligases have been found to support this process.
Zhang X +4 more
europepmc +2 more sources
Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Adverse Effects of Nicotine on Human Sperm Nuclear Proteins [PDF]
The World Journal of Men's HealthThe effects of smoking on human health have long been documented. However, only a few studies have highlighted the direct effects of nicotine on sperm function.
Amir Masoud Firouzabadi +3 more
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Prediction of nuclear proteins using SVM and HMM models
BMC Bioinformatics, 2009 Background The nucleus, a highly organized organelle, plays important role in cellular homeostasis. The nuclear proteins are crucial for chromosomal maintenance/segregation, gene expression, RNA processing/export, and many other processes.
Raghava Gajendra PS, Kumar Manish
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Nuclear proteins and diabetic retinopathy: a review [PDF]
BioMedical Engineering OnLineDiabetic retinopathy (DR) is an eye disease that causes blindness and vision loss in diabetic. Risk factors for DR include high blood glucose levels and some environmental factors.
Bin Li +8 more
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