Results 11 to 20 of about 1,706,990 (206)

Laminopathies: what can humans learn from fruit flies

Cellular & Molecular Biology Letters, 2018
Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins provide a skeletal network for chromatin, the
Marta Pałka, Aleksandra Tomczak, Katarzyna Grabowska, Magdalena Machowska, Katarzyna Piekarowicz, Dorota Rzepecka, Ryszard Rzepecki   +6 more
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Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

iScience, 2023
Summary: The eukaryotic BBSome is a transport complex within cilia and assembled by chaperonin-like BBS proteins. Recent work indicates nuclear functions for BBS proteins in mammals, but it is unclear how common these are in extant proteins or when they ...
Alexander Ewerling, Vanessa Maissl, Bill Wickstead, Helen Louise May-Simera   +3 more
doaj   +1 more source

Improved proteomic analysis of nuclear proteins, as exemplified by the comparison of two myelo\"id cell lines nuclear proteomes [PDF]

, 2012
One of the challenges of the proteomic analysis by 2D-gel is to visualize the low abundance proteins, particularly those localized in organelles. An additional problem with nuclear proteins lies in their strong interaction with nuclear acids.
Chevallet, Mireille, Diemer, Hélène, Lelong, Cécile, Luche, Sylvie, Rabilloud, Thierry, Van Dorsselaer, Alain   +5 more
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Emerin Is Required for Proper Nucleus Reassembly after Mitosis: Implications for New Pathogenetic Mechanisms for Laminopathies Detected in EDMD1 Patients

Cells, 2019
Emerin is an essential LEM (LAP2, Emerin, MAN1) domain protein in metazoans and an integral membrane protein associated with inner and outer nuclear membranes.
Magda Dubińska-Magiera, Katarzyna Kozioł, Magdalena Machowska, Katarzyna Piekarowicz, Daria Filipczak, Ryszard Rzepecki   +5 more
doaj   +1 more source

Protein sub-nuclear localization prediction using SVM and Pfam domain information. [PDF]

PLoS ONE, 2014
The nucleus is the largest and the highly organized organelle of eukaryotic cells. Within nucleus exist a number of pseudo-compartments, which are not separated by any membrane, yet each of them contains only a specific set of proteins.
Ravindra Kumar, Sohni Jain, Bandana Kumari, Manish Kumar   +3 more
doaj   +1 more source

Nuclear protein import [PDF]

Current Opinion in Cell Biology, 1997
The defining feature of eukaryotic organisms is the cell nucleus. All nuclear proteins are synthesized in the cytoplasm and need to be imported through the nuclear pore complexes (NPCs) into the nucleus. Import can be directed by various signals, of which the classical nuclear localization signal (NLS) and the M9 import signal are the best ...
openaire   +3 more sources

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
A. Ganesh, A. Garg, A. Pierleoni, A. Reinhardt, B. Alberts, B. Chan, B. Mathews, D. Xie, E. Marcotte, G. Hutchinson, H. Bannai, M. Hall, M. Kumar, O. Emanuelson, W. Jassem   +14 more
core   +3 more sources

Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment

Cells, 2019
Hutchinson-Gilford progeria syndrome (HGPS) is one of the most severe disorders among laminopathies—a heterogeneous group of genetic diseases with a molecular background based on mutations in the LMNA gene and genes coding for interacting proteins.
Katarzyna Piekarowicz, Magdalena Machowska, Volha Dzianisava, Ryszard Rzepecki   +3 more
doaj   +1 more source

Plastid proteome prediction for diatoms and other algae with secondary plastids of the red lineage [PDF]

, 2014
The plastids of ecologically and economically important algae from phyla such as stramenopiles, dinoflagellates and cryptophytes were acquired via a secondary endosymbiosis and are surrounded by three or four membranes.
Allen, Allen, Altschul, Apt, Armbrust, Ast, Baldi, Bendtsen, Blum, Bowler, Brown, Bruckner, Bullmann, Cavalier-Smith, Cock, Crooks, Curtis, Domergue, Emanuelsson, Emanuelsson, Fawcett, Felsner, Gould, Gould, Grigoriev, Grouneva, Gruber, Gruber, Gruber, Gschloessl, Hall, Hempel, Hempel, Horton, Huesgen, Joshi-Deo, Kilian, Kilian, Kitao, Kitao, Kroth, Kroth, Kroth, Lepetit, Liaud, Mernberger, Moog, Nielsen, Nielsen, Patron, Patron, Petersen, Schneider, Siaut, Sommer, Sturm, Tachibana, Tanaka, Terashima, Timmis, Vugrinec, Weber, Yandell   +62 more
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Molecular aspects of Schistosoma mansoni female maturation

Memorias do Instituto Oswaldo Cruz, 1995
Incubation of total protein extracts of Schistosoma mansoni with 3H 17-beta-estradiol and 20-hydroxyecdysone, revealed steroid binding proteins in both, male and female worms.
Ana Lúcia Moraes Giannini, Sérgio Vasconcelos Linhares, Elena Cristina Caride, Vânia Maria Martins Braga, Franklin David Rumjanek   +4 more
doaj   +1 more source