Results 31 to 40 of about 1,706,990 (206)
Nuclear transport proteins: structure, function and disease relevance
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
doaj +1 more source
Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans [PDF]
, 2018 C. elegans is widely used to investigate biological processes related to health and disease. To study protein localization, fluorescently-tagged proteins can be used in vivo or immunohistochemistry can be performed in whole worms.
Mata Cabana, Alejandro +3 more
core +2 more sources
Cells, 2021 Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho +5 more
doaj +1 more source
Functional Characterization of the Eukaryotic Cysteine Desulfurase Nfs1p from Saccharomyces cerevisiae [PDF]
, 2004 Previous studies have indicated that the essential protein Nfs1 performs a crucial role in cellular iron-sulfur (Fe/S) protein maturation. The protein is located predominantly in mitochondria, yet low amounts are present in cytosol and nucleus.
Balk +73 more
core +3 more sources
The intriguing plant nuclear lamina
Frontiers in Plant Science, 2014 The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska +1 more
doaj +1 more source
Quality control of cytoplasmic proteins inside the nucleus
Computational and Structural Biotechnology Journal, 2022 A complex network of molecular chaperones and proteolytic machinery safeguards the proteins which comprise the proteome, from the time they are synthesized on ribosomes to their destruction via proteolysis. Impaired protein quality control results in the
Lion Borgert +2 more
doaj +1 more source
Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations [PDF]
, 2005 Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins.
Bridger, JM +3 more
core +1 more source
GIP/MZT1 proteins orchestrate nuclear shaping
Frontiers in Plant Science, 2014 The functional organization of the nuclear envelope (NE) is only just emerging in plants with the recent characterization of NE protein complexes and their molecular links to the actin cytoskeleton. The NE also plays a role in microtubule (MT) nucleation
Morgane eBatzenschlager +4 more
doaj +1 more source
The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]
, 2012 Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina +2 more
core +1 more source
The nuclear proteome of Trypanosoma brucei. [PDF]
PLoS ONE, 2017 Trypanosoma brucei is a protozoan flagellate that is transmitted by tsetse flies into the mammalian bloodstream. The parasite has a huge impact on human health both directly by causing African sleeping sickness and indirectly, by infecting domestic ...
Carina Goos +4 more
doaj +1 more source