Results 31 to 40 of about 1,109,521 (262)
Reconstitution of nuclear protein export in isolated nuclear envelopes [PDF]
The Journal of Cell Biology, 2002 Signal-dependent nuclear protein export was studied in perforated nuclei and isolated nuclear envelopes of Xenopus oocytes by optical single transporter recording. Manually isolated and purified oocyte nuclei were attached to isoporous filters and made permeable for macromolecules by perforation.
Siebrasse, Jan Peter +2 more
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A Muscle Hybrid Promoter as a Novel Tool for Gene Therapy
Molecular Therapy: Methods & Clinical Development, 2019 Gene therapy is a promising strategy to cure rare diseases. The lack of regulatory sequences ensuring specific and robust expression in skeletal and cardiac muscle is a substantial limitation of gene therapy efficiency targeting the muscle tissue.
Katarzyna Piekarowicz +7 more
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Mapping the micro-proteome of the nuclear lamina and lamina-associated domains
Life Science Alliance, 2021 The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
Xianrong Wong +6 more
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Nuclear Shape-Shifters: Lipid and Protein Dynamics at the Nuclear Envelope
Cells, 2022 The nuclear envelope constitutes a selective barrier that segregates chromatin into the nucleus of eukaryotic cells [...]
Wolfram Antonin, Symeon Siniossoglou
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Nuclear transport proteins: structure, function and disease relevance
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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Recent advances in understanding the biological roles of the plant nuclear envelope
Nucleus, 2020 The functional organization of the plant nuclear envelope is gaining increasing attention through new connections made between nuclear envelope-associated proteins and important plant biological processes.
Norman Reid Groves +5 more
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Cells, 2021 Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho +5 more
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The intriguing plant nuclear lamina
Frontiers in Plant Science, 2014 The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska +1 more
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Quality control of cytoplasmic proteins inside the nucleus
Computational and Structural Biotechnology Journal, 2022 A complex network of molecular chaperones and proteolytic machinery safeguards the proteins which comprise the proteome, from the time they are synthesized on ribosomes to their destruction via proteolysis. Impaired protein quality control results in the
Lion Borgert +2 more
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GIP/MZT1 proteins orchestrate nuclear shaping
Frontiers in Plant Science, 2014 The functional organization of the nuclear envelope (NE) is only just emerging in plants with the recent characterization of NE protein complexes and their molecular links to the actin cytoskeleton. The NE also plays a role in microtubule (MT) nucleation
Morgane eBatzenschlager +4 more
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