Results 31 to 40 of about 1,114,768 (261)

GIP/MZT1 proteins orchestrate nuclear shaping

Frontiers in Plant Science, 2014
The functional organization of the nuclear envelope (NE) is only just emerging in plants with the recent characterization of NE protein complexes and their molecular links to the actin cytoskeleton. The NE also plays a role in microtubule (MT) nucleation
Morgane eBatzenschlager, Etienne eHERZOG, Guy eHoulné, Anne-Catherine eSchmit, Marie-Edith eChabouté   +4 more
doaj   +1 more source

Nucleoskeleton proteins for nuclear dynamics

The Journal of Biochemistry, 2021
AbstractThe eukaryotic nucleus shows organized structures of chromosomes, transcriptional components and their associated proteins. It has been believed that such a dense nuclear environment prevents the formation of a cytoskeleton-like network of protein filaments. However, accumulating evidence suggests that the cell nucleus also possesses structural
Kei Miyamoto, Masahiko Harata
openaire   +2 more sources

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy

Molecular Therapy: Nucleic Acids
Hutchinson-Gilford progeria syndrome is a fatal genetic disorder caused by a point mutation in the gene encoding the nuclear envelope protein lamin A/C.
Volha Dzianisava, Katarzyna Piekarowicz, Magdalena Machowska, Ryszard Rzepecki   +3 more
doaj   +1 more source

The nuclear proteome of Trypanosoma brucei. [PDF]

PLoS ONE, 2017
Trypanosoma brucei is a protozoan flagellate that is transmitted by tsetse flies into the mammalian bloodstream. The parasite has a huge impact on human health both directly by causing African sleeping sickness and indirectly, by infecting domestic ...
Carina Goos, Mario Dejung, Christian J Janzen, Falk Butter, Susanne Kramer   +4 more
doaj   +1 more source

Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies

Cells
Nuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska, Marta Rowińska, Aleksandra Tomczak, Ryszard Rzepecki   +3 more
doaj   +1 more source

Nuclear variants of bone morphogenetic proteins

BMC Cell Biology, 2010
Background Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation.
Meinhart Christopher A, Gaufin Stephanie L, Sperry Daniel K, Jensen J Daniel, Loos Trina J, Mayo Jaime L, Felin Jenny E, Moss Jennie B, Bridgewater Laura C   +8 more
doaj   +1 more source

Comparative genomics of nuclear envelope proteins

BMC Genomics, 2018
Background The nuclear envelope (NE) that encapsulates the nuclear genome is a double lipid bilayer with several integral and peripherally associated proteins.
Hita Sony Garapati, Krishnaveni Mishra
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Protein interactions at the higher plant nuclear envelope: evidence for a Linker of Nucleoskeleton and Cytoskeleton complex.

Frontiers in Plant Science, 2014
Following the description of SAD1/UNC84 (SUN) domain proteins in higher plants, evidence has rapidly increased that plants contain a functional Linker of Nucleoskeleton and Cytoskeleton (LINC) complex bridging the nuclear envelope (NE).
David Edgar Evans, Vidya ePawar, Sarah Jane Smith, Katja eGraumann   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source