Results 41 to 50 of about 12,222,224 (337)

A Muscle Hybrid Promoter as a Novel Tool for Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2019
Gene therapy is a promising strategy to cure rare diseases. The lack of regulatory sequences ensuring specific and robust expression in skeletal and cardiac muscle is a substantial limitation of gene therapy efficiency targeting the muscle tissue.
Katarzyna Piekarowicz, Anne T. Bertrand, Feriel Azibani, Maud Beuvin, Laura Julien, Magdalena Machowska, Gisèle Bonne, Ryszard Rzepecki   +7 more
doaj   +1 more source

Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells

PLoS ONE, 2013
Human Rhinovirus (HRV) infection results in shut down of essential cellular processes, in part through disruption of nucleocytoplasmic transport by cleavage of the nucleoporin proteins (Nups) that make up the host cell nuclear pore.
E. Walker, P. Younessi, A. Fulcher, R. McCuaig, B. Thomas, P. Bardin, D. Jans, R. Ghildyal   +7 more
semanticscholar   +1 more source

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P., Heiner, M., Leung, Hing, Dalgliesh, C., Bindereif, A, David J Elliott, Dalgliesh, C, Craig N Robson, Dalgliesh Caroline, Elliott, David, Kaveh Emami, Bindereif, A., Heiner Monika, Emami, K, Clark, E.L., Hing Y Leung, Elliott, D.J., Elliott, DJ, Rajan, Prabhakar, Leung Hing Y, Heiner, M, Bourgeois, C.F., Rajan, P, Prabhakar Rajan, Emami, K., Leung, H.Y., Elliott David J, Stevenin James, Stevenin, J., Clark Emma L, Emami, Kaveh, Bindereif, Albrecht, Bourgeois, CF, Bindereif Albrecht, Cyril F Bourgeois, Robson, C.N., Bourgeois, Cyril F, Prabhakar Rajan, Albrecht Bindereif, Heiner, Monika, Caroline Dalgliesh, Robson Craig N, Robson, Craig, Emma L Clark, Clark, EL, Dalgliesh, Caroline, Stevenin, J, Leung, HY, Stevenin, James, Robson, CN, Rajan Prabhakar, Bourgeois Cyril F, Emami Kaveh, Monika Heiner, James Stevenin, Clark, Emma   +55 more
core   +1 more source

Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins [PDF]

, 2006
BACKGROUND: CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers.
Bergman, Lee M., Jeremy P Blaydes, Mirnezami Alexander H, Alexander H Mirnezami, Bergman Lee M, Samal C Gunatilake, Mirnezami, Alexander H., Darley Matthew, Morris Laila, Lee M Bergman, Laila Morris, Darley, Matthew, Gunatilake, Samal C., Blaydes, Jeremy P., Morris, Laila, Matthew Darley, Gunatilake Samal C, Blaydes Jeremy P   +17 more
core   +1 more source

Proteins Connecting the Nuclear Pore Complex with the Nuclear Interior [PDF]

The Journal of Cell Biology, 1999
While much has been learned in recent years about the movement of soluble transport factors across the nuclear pore complex (NPC), comparatively little is known about intranuclear trafficking. We isolated the previously identified Saccharomyces protein Mlp1p (myosin-like protein) by an assay designed to find nuclear envelope (NE) associated proteins ...
C, Strambio-de-Castillia, G, Blobel, M P, Rout   +2 more
openaire   +2 more sources

Recent advances in understanding the biological roles of the plant nuclear envelope

Nucleus, 2020
The functional organization of the plant nuclear envelope is gaining increasing attention through new connections made between nuclear envelope-associated proteins and important plant biological processes.
Norman Reid Groves, Alecia Biel, Morgan Moser, Tyler Mendes, Katelyn Amstutz, Iris Meier   +5 more
doaj   +1 more source

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Nature Chemical Biology, 2013
N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m6A RNA methylation.
Jian-Zhao Liu, Y. Yue, Dali Han, Xiao Wang, Ye Fu, Liang Zhang, G. Jia, Miao Yu, Zhi-Ke Lu, Xin Deng, Qing Dai, Wei-Zhong Chen, Chuan He   +12 more
semanticscholar   +1 more source

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

Cells, 2021
Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho, Barbora Šalovská, Jakub Červenka, Can Balaban, Peter Hoboth, Pavel Hozák   +5 more
doaj   +1 more source

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

eLife, 2017
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this modification is mediated by m6A-selective ‘reader’ proteins of the YTH family, which ...
I. A. Roundtree, Guan-Zheng Luo, Zijie Zhang, Xiao Wang, Tao Zhou, Y. Cui, J. Sha, Xing-Xu Huang, Laura Guerrero, Phil Xie, E. He, Bin Shen, Chuan He   +12 more
semanticscholar   +1 more source

Reconstitution of nuclear protein export in isolated nuclear envelopes [PDF]

The Journal of Cell Biology, 2002
Signal-dependent nuclear protein export was studied in perforated nuclei and isolated nuclear envelopes of Xenopus oocytes by optical single transporter recording. Manually isolated and purified oocyte nuclei were attached to isoporous filters and made permeable for macromolecules by perforation.
Siebrasse, Jan Peter, Coutavas, Elias, Peters, Reiner   +2 more
openaire   +2 more sources