Results 41 to 50 of about 4,009,851 (286)

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy

Molecular Therapy: Nucleic Acids
Hutchinson-Gilford progeria syndrome is a fatal genetic disorder caused by a point mutation in the gene encoding the nuclear envelope protein lamin A/C.
Volha Dzianisava, Katarzyna Piekarowicz, Magdalena Machowska, Ryszard Rzepecki   +3 more
doaj   +1 more source

Nucleoskeleton proteins for nuclear dynamics

The Journal of Biochemistry, 2021
AbstractThe eukaryotic nucleus shows organized structures of chromosomes, transcriptional components and their associated proteins. It has been believed that such a dense nuclear environment prevents the formation of a cytoskeleton-like network of protein filaments. However, accumulating evidence suggests that the cell nucleus also possesses structural
Kei Miyamoto, Masahiko Harata
openaire   +2 more sources

Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies

Cells
Nuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska, Marta Rowińska, Aleksandra Tomczak, Ryszard Rzepecki   +3 more
doaj   +1 more source

Nuclear variants of bone morphogenetic proteins

BMC Cell Biology, 2010
Background Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation.
Meinhart Christopher A, Gaufin Stephanie L, Sperry Daniel K, Jensen J Daniel, Loos Trina J, Mayo Jaime L, Felin Jenny E, Moss Jennie B, Bridgewater Laura C   +8 more
doaj   +1 more source

Comparative genomics of nuclear envelope proteins

BMC Genomics, 2018
Background The nuclear envelope (NE) that encapsulates the nuclear genome is a double lipid bilayer with several integral and peripherally associated proteins.
Hita Sony Garapati, Krishnaveni Mishra
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
Alaol Kabir, Kabir, Alaol, Sakib, Kazi, Kazi Sakib, Hossain, Alamgir, Islam, Md Saiful, Islam, Md. Saiful, Hossain, Md Alamgir, Md. Alamgir Hossain, Md. Saiful Islam   +9 more
core   +1 more source

Protein interactions at the higher plant nuclear envelope: evidence for a Linker of Nucleoskeleton and Cytoskeleton complex.

Frontiers in Plant Science, 2014
Following the description of SAD1/UNC84 (SUN) domain proteins in higher plants, evidence has rapidly increased that plants contain a functional Linker of Nucleoskeleton and Cytoskeleton (LINC) complex bridging the nuclear envelope (NE).
David Edgar Evans, Vidya ePawar, Sarah Jane Smith, Katja eGraumann   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source