Results 21 to 30 of about 1,109,521 (262)
The function of the nuclear envelope in nuclear protein accumulation. [PDF]
The Journal of cell biology, 1988 The mechanism by which proteins accumulate in the cell nucleus is not yet known. Two alternative mechanisms are discussed here: (a) selective unidirectional entry of karyophilic proteins through the nuclear pores, and (b) free diffusion of all proteins through the nuclear pores and specific binding of nuclear proteins to nondiffusible components of the
Zimmer, F., Dreyer, C., Hausen, P.
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Laminopathies: what can humans learn from fruit flies
Cellular & Molecular Biology Letters, 2018 Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins provide a skeletal network for chromatin, the
Marta Pałka +6 more
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iScience, 2023 Summary: The eukaryotic BBSome is a transport complex within cilia and assembled by chaperonin-like BBS proteins. Recent work indicates nuclear functions for BBS proteins in mammals, but it is unclear how common these are in extant proteins or when they ...
Alexander Ewerling +3 more
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Current Opinion in Cell Biology, 1997 The defining feature of eukaryotic organisms is the cell nucleus. All nuclear proteins are synthesized in the cytoplasm and need to be imported through the nuclear pore complexes (NPCs) into the nucleus. Import can be directed by various signals, of which the classical nuclear localization signal (NLS) and the M9 import signal are the best ...
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Protein phosphatases at the nuclear envelope [PDF]
Biochemical Society Transactions, 2018 The nuclear envelope (NE) is a unique topological structure formed by lipid membranes (Inner and Outer Membrane: IM and OM) interrupted by open channels (Nuclear Pore complexes). Besides its well-established structural role in providing a physical separation between the genome and the cytoplasm and regulating the exchanges between the two cellular ...
Raquel Sales Gil +3 more
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Cells, 2019 Emerin is an essential LEM (LAP2, Emerin, MAN1) domain protein in metazoans and an integral membrane protein associated with inner and outer nuclear membranes.
Magda Dubińska-Magiera +5 more
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Protein sub-nuclear localization prediction using SVM and Pfam domain information. [PDF]
PLoS ONE, 2014 The nucleus is the largest and the highly organized organelle of eukaryotic cells. Within nucleus exist a number of pseudo-compartments, which are not separated by any membrane, yet each of them contains only a specific set of proteins.
Ravindra Kumar +3 more
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Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment
Cells, 2019 Hutchinson-Gilford progeria syndrome (HGPS) is one of the most severe disorders among laminopathies—a heterogeneous group of genetic diseases with a molecular background based on mutations in the LMNA gene and genes coding for interacting proteins.
Katarzyna Piekarowicz +3 more
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Molecular aspects of Schistosoma mansoni female maturation
Memorias do Instituto Oswaldo Cruz, 1995 Incubation of total protein extracts of Schistosoma mansoni with 3H 17-beta-estradiol and 20-hydroxyecdysone, revealed steroid binding proteins in both, male and female worms.
Ana Lúcia Moraes Giannini +4 more
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Heat shock protein 60 in vascular biology [PDF]
Scripta MedicaThe response of heat shock proteins (HSPs) to stress-induced stimuli is now well documented and understood. Specific HSPs like HSP70 play an important role in vascular diseases like atherosclerosis and hypertension. However, the involvement of other HSPs
Hedley Thomas E. +3 more
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