Results 11 to 20 of about 146,588 (257)
Dynein at the nuclear envelope [PDF]
The EMBO Reports, 2010 Most cellular organelles are positioned through active transport by motor proteins. The authors discuss the evidence that dynein has important cell cycle-regulated functions in this context at the nuclear envelope.
Tanenbaum, M.E. +2 more
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Recent advances in understanding the biological roles of the plant nuclear envelope
Nucleus, 2020 The functional organization of the plant nuclear envelope is gaining increasing attention through new connections made between nuclear envelope-associated proteins and important plant biological processes.
Norman Reid Groves +5 more
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Cell migration in dense microenvironments
Comptes Rendus Biologies, 2023 The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating ...
de Freitas Nader, Guilherme Pedreira +1 more
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Dystonia and the Nuclear Envelope [PDF]
Neuron, 2005 Mutations in torsinA cause dominantly inherited early-onset torsion dystonia in humans. In this issue of Neuron, Goodchild et al. show that torsinA knockout and knockin mice have similar phenotypes, which suggests that the mutant torsinA allele causes disease because it has decreased function. The experiments also highlight the possible role of nuclear
Cookson, Mark R., Clarimon, Jordi
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Interplay of the nuclear envelope with chromatin in physiology and pathology
Nucleus, 2020 The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins.
Romina Burla +5 more
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Nuclear envelope budding and its cellular functions
Nucleus, 2023 The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Katharina S. Keuenhof +6 more
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TorsinA in the nuclear envelope [PDF]
Proceedings of the National Academy of Sciences, 2004 Early-onset torsion dystonia, a CNS-based movement disorder, is usually associated with a single amino acid deletion (ΔE302/303) in the protein torsinA. TorsinA is an AAA+ ATPase in the endoplasmic reticulum, but what it does is unknown. Here, we use torsinA mutants with defects in ATP hydrolysis (E171Q, ATP-bound) and ATP binding (K108A, ATP-free) to ...
Teresa V, Naismith +3 more
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The Plant Nuclear Envelope and Its Role in Gene Transcription
Frontiers in Plant Science, 2021 Chromosomes are dynamic entities in the eukaryotic nucleus. During cell development and in response to biotic and abiotic change, individual sections as well as entire chromosomes re-organise and reposition within the nuclear space.
Jade Bishop +3 more
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The nuclear envelope at a glance [PDF]
Journal of Cell Science, 2010 The cell nucleus is the ‘mothership’ that organizes, protects and regulates the genome. The inner and outer nuclear membranes (INM and ONM, respectively) of the nuclear envelope (NE) have over 60 distinct membrane proteins, whose roles and functional sophistication might rival the cell surface.
Katherine L, Wilson, Jason M, Berk
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Cold Spring Harbor Perspectives in Biology, 2010 The nuclear envelope (NE) is a highly regulated membrane barrier that separates the nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different proteins that have been implicated in chromatin organization and gene regulation.
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