Results 21 to 30 of about 149,980 (205)

Diseases of the Nuclear Envelope [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
In the past decade, a wide range of fascinating monogenic diseases have been linked to mutations in the LMNA gene, which encodes the A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. These diseases include dilated cardiomyopathy with variable muscular dystrophy, Dunnigan-type familial partial lipodystrophy, a Charcot-Marie ...
Howard J, Worman, Cecilia, Ostlund, Yuexia, Wang   +2 more
openaire   +2 more sources

Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope [PDF]

, 2002
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation.
Gerace, Larry, Schirmer, Eric C
core   +1 more source

AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

eLife, 2020
The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC.
Silvia Vergarajauregui, Robert Becker, Ulrike Steffen, Maria Sharkova, Tilman Esser, Jana Petzold, Florian Billing, Michael S Kapiloff, George Schett, Ingo Thievessen, Felix B Engel   +10 more
doaj   +1 more source

Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase

Cells, 2023
Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs.
Michael Schertzer, Laurent Jullien, André L. Pinto, Rodrigo T. Calado, Patrick Revy, Arturo Londoño-Vallejo   +5 more
doaj   +1 more source

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

The nuclear envelope at a glance [PDF]

Journal of Cell Science, 2010
The cell nucleus is the ‘mothership’ that organizes, protects and regulates the genome. The inner and outer nuclear membranes (INM and ONM, respectively) of the nuclear envelope (NE) have over 60 distinct membrane proteins, whose roles and functional sophistication might rival the cell surface.
Katherine L, Wilson, Jason M, Berk
openaire   +2 more sources

Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit [PDF]

, 2011
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2011 Elsevier Inc.Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome ...
Vagnarelli, Paola, Rappsilber, Juri, Susana Ribeiro, David A. Kelly, Ribeiro, S, Sanchez-Pulido, Luis, Luis Sanchez-Pulido, Ponting, CP, Verheyen, Toon, de Lima Alves, F, Sennels, L, de Lima Alves, Flavia, Ponting, Chris P.; id_orcid, Ponting, Chris P., William C. Earnshaw, Earnshaw, William C., Vagnarelli, P, Sennels, Lau, Kelly, David A., Verheyen, T, Chris P. Ponting, Sanchez-Pulido, L, Ribeiro, Susana, Paola Vagnarelli, Juri Rappsilber, Alves, Flavia de Lima, Kelly, DA, Rappsilber, J, Earnshaw, WC, Lau Sennels, Flavia de Lima Alves, Toon Verheyen   +31 more
core   +1 more source

The nuclear envelopathies and human diseases

Journal of Biomedical Science, 2009
The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope ...
Jeang Kuan-Teh, Chen Zi-Jie, Chi Ya-Hui
doaj   +1 more source

N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

Cell Communication and Signaling, 2023
Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs).
Paulina Gregorczyk, Natalia Porębska, Dominika Żukowska, Aleksandra Chorążewska, Aleksandra Gędaj, Agata Malinowska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński   +8 more
doaj   +1 more source

The Arabidopsis Nuclear Pore and Nuclear Envelope [PDF]

The Arabidopsis Book, 2010
The nuclear envelope is a double membrane structure that separates the eukaryotic cytoplasm from the nucleoplasm. The nuclear pores embedded in the nuclear envelope are the sole gateways for macromolecular trafficking in and out of the nucleus. The nuclear pore complexes assembled at the nuclear pores are large protein conglomerates composed of ...
Iris, Meier, Jelena, Brkljacic
openaire   +2 more sources