Results 21 to 30 of about 146,588 (257)
eLife, 2020 The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC.
Silvia Vergarajauregui +10 more
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Cells, 2023 Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs.
Michael Schertzer +5 more
doaj +1 more source
Diseases of the Nuclear Envelope [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 In the past decade, a wide range of fascinating monogenic diseases have been linked to mutations in the LMNA gene, which encodes the A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. These diseases include dilated cardiomyopathy with variable muscular dystrophy, Dunnigan-type familial partial lipodystrophy, a Charcot-Marie ...
Howard J, Worman +2 more
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The nuclear envelopathies and human diseases
Journal of Biomedical Science, 2009 The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope ...
Jeang Kuan-Teh, Chen Zi-Jie, Chi Ya-Hui
doaj +1 more source
Nuclear envelope remnants: fluid membranes enriched in sterols and polyphosphoinositides.
PLoS ONE, 2009 BackgroundThe cytoplasm of eukaryotic cells is a highly dynamic compartment where membranes readily undergo fission and fusion to reorganize the cytoplasmic architecture, and to import, export and transport various cargos within the cell.
Marie Garnier-Lhomme +7 more
doaj +1 more source
Cell Communication and Signaling, 2023 Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs).
Paulina Gregorczyk +8 more
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The Arabidopsis Nuclear Pore and Nuclear Envelope [PDF]
The Arabidopsis Book, 2010 The nuclear envelope is a double membrane structure that separates the eukaryotic cytoplasm from the nucleoplasm. The nuclear pores embedded in the nuclear envelope are the sole gateways for macromolecular trafficking in and out of the nucleus. The nuclear pore complexes assembled at the nuclear pores are large protein conglomerates composed of ...
Iris, Meier, Jelena, Brkljacic
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Protein phosphatases at the nuclear envelope [PDF]
Biochemical Society Transactions, 2018 The nuclear envelope (NE) is a unique topological structure formed by lipid membranes (Inner and Outer Membrane: IM and OM) interrupted by open channels (Nuclear Pore complexes). Besides its well-established structural role in providing a physical separation between the genome and the cytoplasm and regulating the exchanges between the two cellular ...
Raquel Sales Gil +3 more
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Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling
Cells, 2019 The primary functions of the nuclear envelope are to isolate the nucleoplasm and its contents from the cytoplasm as well as maintain the spatial and structural integrity of the nucleus.
Miki Hieda
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Ultradonut Topology of the Nuclear Envelope [PDF]
Biophysical Journal, 2016 Significance Lipid membranes exhibit a variety of morphologies tailored to perform specific functions of cells and their organelles. A unique lipid structure is the nuclear envelope which houses the genome and plays a vital role in genome organization and signaling pathways. The nuclear envelope is composed of two fused membranes with
University of Houston, Houston, TX, USA ( host institution ) +3 more
openaire +4 more sources