Results 1 to 10 of about 6,851,273 (294)

Nuclear pore complex dysfunction drives TDP-43 pathology in ALS [PDF]

Redox Biology
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and pathological aggregation of TDP-43. While protein misfolding and impaired autophagy are established features, accumulating
O. Ramírez-Núñez, S. Rico-Ríos, P. Torres, V. Ayala, A. Fernàndez-Bernal, M. Ceron-Codorniu, P. Andrés-Benito, A. Vinyals, S. Maqsood, I. Ferrer, R. Pamplona, M. Portero-Otin   +11 more
doaj   +2 more sources

Nuclear pore complex proteins are involved in centromere distribution [PDF]

iScience
Summary: The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker of nucleoskeleton and cytoskeleton (LINC) complex.
Nanami Ito, Takuya Sakamoto, Yuka Oko, Hikaru Sato, Shigeru Hanamata, Yuki Sakamoto, Sachihiro Matsunaga   +6 more
doaj   +2 more sources

Mechanosensing at the Nuclear Envelope by Nuclear Pore Complex Stretch Activation and Its Effect in Physiology and Pathology

Frontiers in Physiology, 2019
Cell fate is correlated to mechanotransduction, in which forces transmitted by the cytoskeleton filaments alter the nuclear shape, affecting transcription factor import/export, cells transcription activity and chromatin distribution.
F. Donnaloja, E. Jacchetti, M. Soncini, M. T. Raimondi   +3 more
doaj   +1 more source

A Novel Saccharomyces cerevisiae FG Nucleoporin Mutant Collection for Use in Nuclear Pore Complex Functional Experiments

G3: Genes, Genomes, Genetics, 2016
FG nucleoporins (Nups) are the class of proteins that both generate the permeability barrier and mediate selective transport through the nuclear pore complex (NPC).
Rebecca L. Adams, Laura J. Terry, Susan R. Wente   +2 more
doaj   +1 more source

Detecting Selective Protein Binding Inside Plasmonic Nanopores: Toward a Mimic of the Nuclear Pore Complex

Frontiers in Chemistry, 2018
Biosensors based on plasmonic nanostructures offer label-free and real-time monitoring of biomolecular interactions. However, so do many other surface sensitive techniques with equal or better resolution in terms of surface coverage.
Bita Malekian, Rafael L. Schoch, Timothy Robson, Gustav Ferrand -Drake del Castillo, Kunli Xiong, Gustav Emilsson, Larisa E. Kapinos, Roderick Y. H. Lim, Andreas Dahlin   +8 more
doaj   +1 more source

High-resolution nuclear cell biology by cryo-electron tomography

Nucleus
The nucleus is a structurally diverse and dynamic organelle that anchors chromatin and orchestrates a large number of essential processes, including transcription, replication, ribosome biogenesis, and nucleocytoplasmic transport.
Zanetta Kechagia, Ohad Medalia
doaj   +1 more source

Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells.

PLoS ONE, 2011
BackgroundTpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human.Methodology/principal findingsHere we show that depletion of Tpr by RNA ...
Brigitte David-Watine
doaj   +1 more source

Mechanobiology of the nucleus during the G2-M transition

Nucleus
Cellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events.
Joana T. Lima, Jorge G. Ferreira
doaj   +1 more source

Desmin’s conformational modulation by hydrophobicity

Türk Biyokimya Dergisi
Nucleocytoplasmic transport is one of the key features in regulation of cellular physiology. Developing a better understanding of the molecular mechanism underlying the nucleocytoplasmic shuttling of proteins can broaden our perspective and understanding
Kural Mangıt Ecem, Cevheroğlu Orkun, Dinçer Pervin   +2 more
doaj   +1 more source

Not just binary: embracing the complexity of nuclear division dynamics

Nucleus
Cell division presents a challenge for eukaryotic cells: how can chromosomes effectively segregate within the confines of a membranous nuclear compartment?
Madison E. Walsh, Grant A. King, Elçin Ünal   +2 more
doaj   +1 more source