Results 41 to 50 of about 6,851,273 (294)

Poring over pores: nuclear pore complex insertion into the nuclear envelope

Trends in Biochemical Sciences, 2013
The nuclear boundary is formed by the nuclear envelope (NE), a double membrane system that establishes a selective barrier between the nucleoplasm and the cytoplasm. Its barrier characteristics are determined by nuclear pore complexes (NPCs); huge protein assemblies that guard nucleocytoplasmic compartmentalization.
Rothballer Andrea, Kutay Ulrike
openaire   +3 more sources

Structural and functional characterization of the p62 complex, a subcomplex of the nuclear pore complex [PDF]

, 2008
The nuclear pore complex (NPC) is a highly conserved eukaryotic protein complex, which perforates the nuclear envelope and regulates nucleocytoplasmic transport of cargos between the cytoplasm and nucleus.
Schwarz-Herion, Kyrill
core   +1 more source

Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells

Cell Reports, 2018
Summary: Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mESC ...
Benoit Souquet, Ellen Freed, Alessandro Berto, Vedrana Andric, Nicolas Audugé, Bernardo Reina-San-Martin, Elizabeth Lacy, Valérie Doye   +7 more
doaj   +1 more source

Kap-Centric control of nuclear pores based on promiscuous binding to FG nucleoporins [PDF]

, 2014
Nuclear pore complexes (NPCs) are remarkable molecular machines that perforate the nuclear envelope (NE) in eukaryotic cells and mediate the rapid bidirectional traffic of hundreds of proteins, ribonucleoproteins, and metabolites across the nuclear ...
Wagner, Raphael S.
core   +1 more source

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Nature Communications, 2021
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter   +17 more
doaj   +1 more source

Characterization of the cellular functions of the nucleoporins Nup153 and Nup88 [PDF]

, 2010
Characterization of the Cellular Functions of the Nucleoporins Nup153 and Nup88 PhD Thesis, Yvonne Christine Lussi, 2010, University of Basel Nuclear pore complexes (NPCs) and nuclear lamins are major constituents of the nuclear envelope (NE) in ...
Lussi, Yvonne Christine
core   +1 more source

Temporal Changes in Nuclear Envelope Permeability during Semi-Closed Mitosis in Dictyostelium Amoebae

Cells, 2023
The Amoebozoan Dictyostelium discoideum exhibits a semi-closed mitosis in which the nuclear membranes remain intact but become permeabilized to allow tubulin and spindle assembly factors to access the nuclear interior.
Kristina Mitic, Irene Meyer, Ralph Gräf, Marianne Grafe   +3 more
doaj   +1 more source

Nuclear magnetic resonance cryoporometry [PDF]

, 2008
Nuclear Magnetic Resonance (NMR) cryoporometry is a technique for non-destructively determining pore size distributions in porous media through the observation of the depressed melting point of a confined liquid.
Webber, J. Beau W., Strange, John H., Strange, J H, Webber, Beau, Mitchell, J., Mitchell, J   +5 more
core   +1 more source

Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

Life Science Alliance, 2022
Characterization of nuclear pores in Schizosaccharomyces pombe identifies regions of heterogeneous NPC density and composition and shows that NPCs are excluded near the spindle pole body by Lem2-mediated centromere tethering.
Joseph M Varberg, Jay R Unruh, Andrew J Bestul, Azqa A Khan, Sue L Jaspersen   +4 more
doaj   +1 more source

Nuclear pore complex biogenesis

Current Opinion in Cell Biology, 2009
Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in ...
Javier, Fernandez-Martinez, Michael P, Rout   +1 more
openaire   +3 more sources