Results 1 to 10 of about 1,855,818 (295)

Exportins can inhibit major mitotic assembly events in vitro: membrane fusion, nuclear pore formation, and spindle assembly

Nucleus, 2020
Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord, Cyril Bernis, Sarah Carmona, Dennis C. Garland, Anna Travesa, Douglass J. Forbes   +5 more
doaj   +1 more source

NUP214 in Acute Myeloid Leukemia

Cells
Nucleoporin 214 (NUP214) is a component of the nucleopore molecular complex, but in addition to this role in nucleocytoplasmic transport it is also involved in the regulation of gene transcription/translation, intracellular signaling, cell cycle ...
Øystein Bruserud, Håkon Reikvam
doaj   +1 more source

INO1 transcriptional memory leads to DNA zip code-dependent interchromosomal clustering

Microbial Cell, 2015
Many genes localize at the nuclear periphery through physical interaction with the nuclear pore complex (NPC). We have found that the yeast INO1 gene is targeted to the NPC both upon activation and for several generations after repression, a phenomenon ...
Donna Garvey Brickner, Robert Coukos, Jason H. Brickner   +2 more
doaj   +1 more source

Detection of TurboID fusion proteins by fluorescent streptavidin outcompetes antibody signals and visualises targets not accessible to antibodies

eLife
Immunofluorescence localises proteins via fluorophore-labelled antibodies. However, some proteins evade detection due to antibody-accessibility issues or because they are naturally low abundant or antigen density is reduced by the imaging method.
Johanna Odenwald, Bernardo Gabiatti, Silke Braune, Siqi Shen, Martin Zoltner, Susanne Kramer   +5 more
doaj   +1 more source

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease

eLife
The emergence of Aβ pathology is one of the hallmarks of Alzheimer’s disease (AD), but the mechanisms and impact of Aβ in progression of the disease is unclear.
Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch'ng   +5 more
doaj   +1 more source

A tool to pulse-label yeast nuclear pore complexes in imaging and biochemical experiments. [PDF]

Elife
Veldsink AC, Fischer JS, Hell S, Weis K, Veenhoff LM.   +4 more
europepmc   +2 more sources

The nuclear pore complex as a spatial organizing hub for high-risk DNA lesions. [PDF]

Nucleus
DeAscanis D, Nam B, Song H, Kee Y.
europepmc   +1 more source

Mlp1 and Mlp2 cooperate to build a stoichiometric nuclear pore basket in budding yeast. [PDF]

J Cell Sci
Schmidt K, Schürch AP, Dultz E.
europepmc   +1 more source

The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats. [PDF]

Nucleic Acids Res
Ollivaud S, Novarina D, Riquelme Barrientos EC, Kazemier HG, Gonera S, Kislanski M, Veenhoff LM, Chang M.   +7 more
europepmc   +2 more sources

Artificial Nuclear Pore Complexes with Exceptionally Selective Shuttle-Cargo Transport. [PDF]

ACS Nano
Medin J, Santoso B, Beckerman L, Vattikunta R, Hailes R, Andersson J, Dahlin A.   +6 more
europepmc   +1 more source