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Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View [PDF]

Cells, 2022
In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters, Alexandra C. A. Piët, Maarten Fornerod   +2 more
doaj   +2 more sources

Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]

The EMBO Journal
Brl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal, Annett Neuner, Azqa Ajmal Khan, Jlenia Vitale, Elmar Schiebel   +4 more
doaj   +2 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +2 more sources

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion [PDF]

Nature Communications
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-
Junyan Lin, Arantxa Agote-Aran, Yongrong Liao, Mehdi Cloarec, Leonid Andronov, Rafael L. Schoch, Paolo Ronchi, Victor Cochard, Rui Zhu, Erwan Grandgirard, Xiaotian Liu, Marianne Victoria Lemée, Charlotte Kleiss, Christelle Golzio, Marc Ruff, Guillaume Chevreux, Yannick Schwab, Bruno P. Klaholz, Izabela Sumara   +18 more
doaj   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control [PDF]

FEBS Open Bio
In budding yeast, the replication fork blocking protein Fob1 arrests replication forks at the ribosomal RNA gene (rDNA) locus, leading to DNA double‐strand breaks that promote genomic instability and limit replicative lifespan.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
doaj   +2 more sources

Protocol to image and quantify nuclear pore complexes using high-resolution laser scanning confocal microscopy

STAR Protocols, 2023
Summary: Nuclear pore complexes are pathways for nuclear-cytoplasmic communication that participate in chromatin organization. Here, we present a protocol to image and quantify the number of nuclear pore complexes in cells.
Jocelyn D. Mich-Basso, Bernhard Kühn
doaj   +1 more source

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

Acta Neuropathologica Communications, 2021
Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj   +1 more source

Structure, Function and Assembly of Nuclear Pore Complexes [PDF]

Nature Reviews Molecular Cell Biology
Stefan Petrović, Andre Hoelz, George W Mobbs   +2 more
exaly   +2 more sources

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

Open Biology, 2021
The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang, Azqa Khan, Jlenia Vitale, Annett Neuner, Kerstin Rink, Christian Lüchtenborg, Britta Brügger, Thomas H. Söllner, Elmar Schiebel   +8 more
doaj   +1 more source

Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore

Cell Reports, 2020
Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang, Ryuji Watanabe, Hide A. Konishi, Takahiro Fujiwara, Shige H. Yoshimura, Masahiro Kumeta   +5 more
doaj   +1 more source