Results 1 to 10 of about 159,475 (307)

Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]

The EMBO Journal
Brl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal, Annett Neuner, Azqa Ajmal Khan, Jlenia Vitale, Elmar Schiebel   +4 more
doaj   +2 more sources

The nuclear pore complex [PDF]

The Journal of cell biology, 1993
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport.
Eduard C. Hurt, Hurt, Eduard C.
core   +8 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +2 more sources

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion [PDF]

Nature Communications
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-
Junyan Lin, Arantxa Agote-Aran, Yongrong Liao, Mehdi Cloarec, Leonid Andronov, Rafael L. Schoch, Paolo Ronchi, Victor Cochard, Rui Zhu, Erwan Grandgirard, Xiaotian Liu, Marianne Victoria Lemée, Charlotte Kleiss, Christelle Golzio, Marc Ruff, Guillaume Chevreux, Yannick Schwab, Bruno P. Klaholz, Izabela Sumara   +18 more
doaj   +2 more sources

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]

mBio
Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
doaj   +2 more sources

Nuclear Envelope: Nuclear Pore Complexity [PDF]

Current Biology, 2005
A new study shows that the filamentous fungus, Aspergillus nidulans, which has a closed mitosis, does not maintain a continuous permeability barrier during mitosis. This work challenges current views of the differences between closed and open mitosis and
Sazer, Shelley
core   +3 more sources

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease [PDF]

eLife
The emergence of Aβ pathology is one of the hallmarks of Alzheimer’s disease (AD), but the mechanisms and impact of Aβ in progression of the disease is unclear.
Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch'ng   +5 more
doaj   +2 more sources

Structure, function and assembly of nuclear pore complexes [PDF]

Nature Reviews Molecular Cell Biology
George W Mobbs, André Hoelz, Hoelz André   +2 more
exaly   +2 more sources

Protocol to image and quantify nuclear pore complexes using high-resolution laser scanning confocal microscopy

STAR Protocols, 2023
Summary: Nuclear pore complexes are pathways for nuclear-cytoplasmic communication that participate in chromatin organization. Here, we present a protocol to image and quantify the number of nuclear pore complexes in cells.
Jocelyn D. Mich-Basso, Bernhard Kühn
doaj   +1 more source

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

Acta Neuropathologica Communications, 2021
Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj   +1 more source