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Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]
The EMBO JournalBrl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal +4 more
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RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion [PDF]
Nature CommunicationsNuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-
Junyan Lin +18 more
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The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]
Frontiers in Cell and Developmental BiologyThe nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu +10 more
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Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]
mBioViruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
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Structure, function and assembly of nuclear pore complexes [PDF]
Nature Reviews Molecular Cell BiologyAndré Hoelz, Hoelz André
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The nuclear pore complex [PDF]
The Journal of cell biology, 1993 Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field.
Panté N, Aebi U
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STAR Protocols, 2023 Summary: Nuclear pore complexes are pathways for nuclear-cytoplasmic communication that participate in chromatin organization. Here, we present a protocol to image and quantify the number of nuclear pore complexes in cells.
Jocelyn D. Mich-Basso, Bernhard Kühn
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Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
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Glycosylation of the Nuclear Pore [PDF]
Traffic, 2014 The O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) posttranslational modification was first discovered 30 years ago and is highly concentrated in the nuclear pore. In the years since the discovery of this single sugar modification, substantial progress has been made in understanding the biochemistry of O‐GlcNAc and its regulation.
Bin, Li, Jennifer J, Kohler
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A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
Open Biology, 2021 The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang +8 more
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