Results 31 to 40 of about 1,855,818 (295)

Poring over pores: nuclear pore complex insertion into the nuclear envelope

Trends in Biochemical Sciences, 2013
The nuclear boundary is formed by the nuclear envelope (NE), a double membrane system that establishes a selective barrier between the nucleoplasm and the cytoplasm. Its barrier characteristics are determined by nuclear pore complexes (NPCs); huge protein assemblies that guard nucleocytoplasmic compartmentalization.
Rothballer Andrea, Kutay Ulrike
openaire   +3 more sources

Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks – Implications for nuclear pore permeability [PDF]

, 2013
Nuclear pore complexes control the exchange of macromolecules between the cytoplasm and the nucleus. A selective permeability barrier that arises from a supramolecular assembly of intrinsically unfolded nucleoporin domains rich in phenylalanine-glycine ...
Frey, S., Labokha, Aksana A., Eisele, Nico B., Frey, Steffen, Görlich, D., Richter, Ralf P., Eisele, N., Richter, R., Steffen Frey, Dirk Görlich, Richter , R., Labokha, A., Ralf P. Richter, Aksana A. Labokha, Görlich, Dirk, Nico B. Eisele, Goerlich, D.   +16 more
core   +1 more source

Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers

Communications Biology, 2023
Nucleoporins (NUPs) comprise nuclear pore complexes, gateways for nucleocytoplasmic transport. As primary human keratinocytes switch from the progenitor state towards differentiation, most NUPs are strongly downregulated, with NUP93 being the most ...
Amy E. Neely, Yang Zhang, Laura A. Blumensaadt, Hongjing Mao, Benjamin Brenner, Cheng Sun, Hao F. Zhang, Xiaomin Bao   +7 more
doaj   +1 more source

New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation

Frontiers in Cell and Developmental Biology, 2021
The condensation and compartmentalization of biomacromolecules in the cell are driven by the process of phase separation. The main effectors of phase separation are intrinsically disordered proteins, which include proteins with a phenylalanine-glycine ...
Yoichi Shinkai, Masahiro Kuramochi, Takamitsu Miyafusa   +2 more
doaj   +1 more source

The Nuclear Pore Complex and Nuclear Transport [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Internal membrane bound structures sequester all genetic material in eukaryotic cells. The most prominent of these structures is the nucleus, which is bounded by a double membrane termed the nuclear envelope (NE). Though this NE separates the nucleoplasm and genetic material within the nucleus from the surrounding cytoplasm, it is studded throughout ...
Susan R, Wente, Michael P, Rout
openaire   +2 more sources

Nuclear magnetic resonance cryoporometry [PDF]

, 2008
Nuclear Magnetic Resonance (NMR) cryoporometry is a technique for non-destructively determining pore size distributions in porous media through the observation of the depressed melting point of a confined liquid.
Webber, J. Beau W., Strange, John H., Strange, J H, Webber, Beau, Mitchell, J., Mitchell, J   +5 more
core   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells.

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Schirmer, Eric C, Eric C. Schirmer, Ohba, Tomoyuki, Tomoyuki Ohba, Takeharu Nishimoto, Larry Gerace   +7 more
core   +1 more source

Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA Formation

Viruses, 2021
Hepatitis B virus (HBV) remains a major public health concern, with more than 250 million chronically infected people who are at high risk of developing liver diseases, including cirrhosis and hepatocellular carcinoma.
João Diogo Dias, Nazim Sarica, Christine Neuveut   +2 more
doaj   +1 more source

The nuclear pore complex : its role in chromatin structure and RNA export [PDF]

, 2015
Epigenetic regulation of gene expression is a relatively new and rapidly developing research field. It studies the mechanisms of regulation of gene expression, which although heritable, occur independently of changes in the DNA sequence and certainly aid
Hristova, Emilia
core   +1 more source