Metabolic transcriptional memory [PDF]
Molecular Metabolism, 2020 Background: Organisms can be primed by metabolic exposures to continue expressing response genes even once the metabolite is no longer available, and can affect the speed and magnitude of responsive gene expression during subsequent exposures.
Poonam Bheda
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Genomic and epigenomic determinants of heat stress-induced transcriptional memory in Arabidopsis [PDF]
Genome Biology, 2023 Background Transcriptional regulation is a key aspect of environmental stress responses. Heat stress induces transcriptional memory, i.e., sustained induction or enhanced re-induction of transcription, that allows plants to respond more efficiently to a ...
Christian Kappel +6 more
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Establishment and inheritance of epigenetic transcriptional memory [PDF]
Frontiers in Molecular Biosciences, 2022 For certain inducible genes, the rate and molecular mechanism of transcriptional activation depends on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation and requires both changes in ...
Bethany Sump, Jason Brickner
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Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory [PDF]
eLife, 2022 For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in ...
Bethany Sump +4 more
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Vegetal memory through the lens of transcriptomic changes – recent progress and future practical prospects for exploiting plant transcriptional memory [PDF]
Plant Signaling & BehaviorPlant memory plays an important role in the efficient and rapid acclimation to a swiftly changing environment. In addition, since plant memory can be inherited, it is also of adaptive and evolutionary importance.
Dóra Farkas, Judit Dobránszki
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The Mediator kinase module enhances polymerase activity to regulate transcriptional memory after heat stress in Arabidopsis [PDF]
The EMBO JournalPlants are often exposed to recurring adverse environmental conditions in the wild. Acclimation to high temperatures entails transcriptional responses, which prime plants to better withstand subsequent stress events.
Tim Crawford +8 more
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Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation [PDF]
Nature Communications, 2023 Transcriptional memory is key for cellular adaptation. Here the authors show that differences in mRNA stability and mRNA degradation machinery between naïve and primed cells facilitate faster gene expression response to repeated stimuli.
Bingnan Li +10 more
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Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness [PDF]
eLife, 2020 Transcriptional memory allows certain genes to respond to previously experienced signals more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates transcriptional memory are poorly understood.
Zuodong Zhao +8 more
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Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory
Molecular Cell, 2020 Summary Cytokine activation of cells induces gene networks involved in inflammation and immunity. Transient gene activation can have a lasting effect even in the absence of ongoing transcription, known as long-term transcriptional memory. Here we explore
Sahar S H Tehrani +2 more
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The Past Determines the Future: Sugar Source History and Transcriptional Memory [PDF]
Current Genetics, 2020 Transcriptional reinduction memory is a phenomenon whereby cells “remember” their transcriptional response to a previous stimulus such that subsequent encounters with the same stimulus can result in altered gene expression kinetics.
Robert Schneider +2 more
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