The elusive transcriptional memory trace. [PDF]
Oxf Open Neurosci, 2022 Memory is the brain faculty to store and remember information. It is a sequential process in which four different phases can be distinguished: encoding or learning, consolidation, storage and reactivation. Since the discovery of the first Drosophila gene
Gil-Marti B +5 more
europepmc +7 more sources
Transcriptional and Post-Transcriptional Regulation and Transcriptional Memory of Chromatin Regulators in Response to Low Temperature [PDF]
Frontiers in Plant Science, 2020 Chromatin regulation ensures stable repression of stress-inducible genes under non-stress conditions and transcriptional activation and memory of stress-related genes after stress exposure.
Kora Vyse +6 more
doaj +7 more sources
Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1. [PDF]
Nat Aging, 2022 A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal ageing as animals encounter a multitude ...
Martínez Corrales G +7 more
europepmc +4 more sources
Inheritance of epigenetic transcriptional memory. [PDF]
Curr Opin Genet DevEpigenetic memory allows organisms to stably alter their transcriptional program in response to developmental or environmental stimuli. These transcriptional programs are regulated by heritable regulation of the function of enhancers and promoters ...
Ge T, Brickner JH.
europepmc +4 more sources
Nup98-dependent transcriptional memory is established independently of transcription [PDF]
eLife, 2022 Cellular ability to mount an enhanced transcriptional response upon repeated exposure to external cues is termed transcriptional memory, which can be maintained epigenetically through cell divisions and can depend on a nuclear pore component Nup98.
Pau Pascual-Garcia +2 more
doaj +5 more sources
The control of transcriptional memory by stable mitotic bookmarking. [PDF]
Nat Commun, 2022 To maintain cellular identities during development, gene expression profiles must be faithfully propagated through cell generations. The reestablishment of gene expression patterns upon mitotic exit is mediated, in part, by transcription factors (TF ...
Bellec M +14 more
europepmc +9 more sources
STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory. [PDF]
EMBO J, 2023 Exposure of human cells to interferon‐γ (IFNγ) results in a mitotically heritable yet reversible state called long‐term transcriptional memory. We previously identified the clustered GBP genes as strongly primed by IFNγ.
Tehrani SS +5 more
europepmc +2 more sources
Histone retention preserves epigenetic marks during heat stress-induced transcriptional memory in plants. [PDF]
EMBO J, 2023 Plants often experience recurrent stressful events, for example, during heat waves. They can be primed by heat stress (HS) to improve the survival of more severe heat stress conditions.
Pratx L +4 more
europepmc +2 more sources
Inheritance of epigenetic transcriptional memory through read-write replication of a histone modification. [PDF]
Ann N Y Acad Sci, 2023 Epigenetic transcriptional regulation frequently requires histone modifications. Some, but not all, of these modifications are able to template their own inheritance.
Brickner JH.
europepmc +2 more sources
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling. [PDF]
Nat Struct Mol BiolInterferon-γ (IFNγ) transiently activates genes related to inflammation and innate immunity. A subset of targets retain a mitotically heritable memory of prior IFNγ exposure, resulting in hyperactivation upon re-exposure through poorly understood ...
Mikulski P +7 more
europepmc +2 more sources