Results 21 to 30 of about 125,147 (241)
Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes
Frontiers in Endocrinology, 2021 Insulin injection is currently the main therapy for type 1 diabetes (T1D) or late stage of severe type 2 diabetes (T2D). Human pancreatic islet transplantation confers a significant improvement in glycemic control and prevents life-threatening severe ...
Meghan Tahbaz +2 more
doaj +1 more source
The past determines the future: sugar source history and transcriptional memory [PDF]
Current Genetics, 2020 Poonam Bheda +2 more
exaly +2 more sources
Learning, Memory, and Transcription Factors [PDF]
Pediatric Research, 2003 Cognitive disorders in children have traditionally been described in terms of clinical phenotypes or syndromes, chromosomal lesions, metabolic disorders, or neuropathology. Relatively little is known about how these disorders affect the chemical reactions involved in learning and memory.
Michael V, Johnston +2 more
openaire +2 more sources
Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory
Molecular Cell, 2020 Wojciech Siwek +2 more
exaly +2 more sources
The Regulation of Transcription in Memory Consolidation [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 De novo transcription of DNA is a fundamental requirement for the formation of long-term memory. It is required during both consolidation and reconsolidation, the posttraining and postreactivation phases that change the state of the memory from a fragile into a stable and long-lasting form.
Cristina M, Alberini, Eric R, Kandel
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Frontiers in Cell and Developmental Biology, 2021 Polycomb group (PcG) and trithorax group (trxG) proteins are evolutionary conserved factors that contribute to cell fate determination and maintenance of cellular identities during development of multicellular organisms.
Muhammad Haider Farooq Khan +8 more
doaj +1 more source
Transcriptional Memory in the Drosophila Embryo [PDF]
Current Biology, 2016 Transmission of active transcriptional states from mother to daughter cells has the potential to foster precision in the gene expression programs underlying development. Such transcriptional memory has been specifically proposed to promote rapid reactivation of complex gene expression profiles after successive mitoses in Drosophila development [1].
Ferraro, Teresa +9 more
openaire +3 more sources
Epigenetic memory contributing to the pathogenesis of AKI-to-CKD transition
Frontiers in Molecular Biosciences, 2022 Epigenetic memory, which refers to the ability of cells to retain and transmit epigenetic marks to their daughter cells, maintains unique gene expression patterns.
Fumiaki Tanemoto +2 more
doaj +1 more source
Creating memories of transcription [PDF]
Proceedings of the National Academy of Sciences, 2013 Two genetically identical cells grown under the same conditions can exhibit stochastic fluctuations in gene expression. Such cell-to-cell variation in expression of key genes is hypothesized to help drive developmental fate decisions and cell specialization during differentiation.
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Histone Methylation and Memory of Environmental Stress
Cells, 2019 Cellular adaptation to environmental stress relies on a wide range of tightly controlled regulatory mechanisms, including transcription. Changes in chromatin structure and organization accompany the transcriptional response to stress, and in some cases ...
Paola Fabrizio +2 more
doaj +1 more source