Results 41 to 50 of about 125,147 (241)

Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics

Cell Reports, 2020
Summary: Antibody memory protects humans from many diseases. Protective antibody memory responses require activation of transcriptional programs, cell proliferation, and production of antigen-specific antibodies, but how these aspects of the response are
Felix Horns, Cornelia L. Dekker, Stephen R. Quake   +2 more
doaj   +1 more source

Roles and Transcriptional Responses of Inhibitory Neurons in Learning and Memory

Frontiers in Molecular Neuroscience, 2021
Increasing evidence supports a model whereby memories are encoded by sparse ensembles of neurons called engrams, activated during memory encoding and reactivated upon recall.
Corinna Giorgi, Corinna Giorgi, Silvia Marinelli   +2 more
doaj   +1 more source

Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse

Translational Psychiatry, 2023
Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-associated memories. Memories are thought to temporarily destabilize upon retrieval during the reconsolidation process.
Koral Goltseker, Patricia Garay, Katherine Bonefas, Shigeki Iwase, Segev Barak   +4 more
doaj   +1 more source

Source cell-type epigenetic memory persists in induced pluripotent cells but is lost in subsequently derived germline cells

Frontiers in Cell and Developmental Biology
Introduction: Retention of source cell-type epigenetic memory may mitigate the potential for induced pluripotent stem cells (iPSCs) to fully achieve transitions in cell fate in vitro. While this may not preclude the use of iPSC-derived somatic cell types
Yu-Huey Lin, Jake D. Lehle, John R. McCarrey   +2 more
doaj   +1 more source

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila

Nature Communications, 2021
The flexibility of memory updating may be determined in the initial memory consolidation process. Here, the authors show the proteomic changes of the transcriptional repressor complexes required for initial memory consolidation and influencing the ...
Mai Takakura, Reiko Nakagawa, Takeshi Ota, Yoko Kimura, Man Yung NG, Abdalla G. Alia, Hiroyuki Okuno, Yukinori Hirano   +7 more
doaj   +1 more source

Next generation synthetic memory via intercepting recombinase function

Nature Communications, 2023
Here we present a technology to facilitate synthetic memory in a living system via repurposing Transcriptional Programming (i.e., our decision-making technology) parts, to regulate (intercept) recombinase function post-translation.
Andrew E. Short, Dowan Kim, Prasaad T. Milner, Corey J. Wilson   +3 more
doaj   +1 more source

CSN5A Subunit of COP9 Signalosome Is Required for Resetting Transcriptional Stress Memory after Recurrent Heat Stress in Arabidopsis

Biomolecules, 2021
In nature, plants are exposed to several environmental stresses that can be continuous or recurring. Continuous stress can be lethal, but stress after priming can increase the tolerance of a plant to better prepare for future stresses.
Amit Kumar Singh, Shanmuhapreya Dhanapal, Alin Finkelshtein, Daniel A. Chamovitz   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Single-cell transcriptome analysis of CD8+ T-cell memory inflation [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”.
Andrew J. Highton, Madeleine E. Zinser, Lian Ni Lee, Claire L. Hutchings, Catherine De Lara, Chansavath Phetsouphanh, Chris B. Willberg, Claire L. Gordon, Paul Klenerman, Emanuele Marchi   +9 more
doaj   +1 more source

A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. [PDF]

PLoS Biology, 2013
The interaction of nuclear pore proteins (Nups) with active genes can promote their transcription. In yeast, some inducible genes interact with the nuclear pore complex both when active and for several generations after being repressed, a phenomenon ...
William H Light, Jonathan Freaney, Varun Sood, Abbey Thompson, Agustina D'Urso, Curt M Horvath, Jason H Brickner   +6 more
doaj   +1 more source