Results 61 to 70 of about 5,670,610 (287)

Maintaining a memory by transcriptional autoregulation [PDF]

Current Biology, 2011
One of the key features of cellular differentiation programs is stability. Although differentiation is reversible in principle, many components of the gene batteries induced upon terminal differentiation are maintained throughout a cell's life. For example, muscle cells continuously express the myosin gene, and GABAergic neurons continuously express ...
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Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse

Translational Psychiatry, 2023
Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-associated memories. Memories are thought to temporarily destabilize upon retrieval during the reconsolidation process.
Koral Goltseker, Patricia Garay, Katherine Bonefas, Shigeki Iwase, Segev Barak   +4 more
doaj   +1 more source

Transcriptional Memory: Staying in the Loop [PDF]

Current Biology, 2010
Actively transcribed genes are organized into loops in which the 5' and 3' ends of the gene physically associate. Two new papers show that gene looping can persist after genes are repressed, promoting rapid reactivation of transcription, a phenomenon known as transcriptional memory.
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Transcriptional co-repressors and memory storage [PDF]

Neuropharmacology, 2014
Epigenetic modifications are a central mechanism for regulating chromatin structure and gene expression in the brain. A wide array of histone- and DNA-modifying enzymes have been identified as critical regulators of neuronal function, memory formation, and as causative agents in neurodevelopmental and neuropsychiatric disorders.
Hannah Schoch, Ted Abel
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Transcriptional regulation of memory B cell differentiation [PDF]

Nature Reviews Immunology, 2020
Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been ...
Brian J. Laidlaw, Jason G. Cyster
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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism [PDF]

, 2011
In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2).
Finlay, David, Sinclair, Linda V., Peter Tamas, Okkenhaug, Klaus, Klaus Okkenhaug, Doreen A. Cantrell, Cantrell, Doreen A., Andrew N. Macintyre, David Finlay, Waugh, Caryll M., Carmen Feijoo, Feijoo, Carmen, Tamas, Peter, Macintyre, Andrew N., Preston, Gavin, Gavin Preston, Linda V. Sinclair, Caryll M. Waugh   +17 more
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Source cell-type epigenetic memory persists in induced pluripotent cells but is lost in subsequently derived germline cells

Frontiers in Cell and Developmental Biology
Introduction: Retention of source cell-type epigenetic memory may mitigate the potential for induced pluripotent stem cells (iPSCs) to fully achieve transitions in cell fate in vitro. While this may not preclude the use of iPSC-derived somatic cell types
Yu-Huey Lin, Jake D. Lehle, John R. McCarrey   +2 more
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Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics

Cell Reports, 2020
Summary: Antibody memory protects humans from many diseases. Protective antibody memory responses require activation of transcriptional programs, cell proliferation, and production of antigen-specific antibodies, but how these aspects of the response are
Felix Horns, Cornelia L. Dekker, Stephen R. Quake   +2 more
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A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. [PDF]

PLoS Biology, 2013
The interaction of nuclear pore proteins (Nups) with active genes can promote their transcription. In yeast, some inducible genes interact with the nuclear pore complex both when active and for several generations after being repressed, a phenomenon ...
William H Light, Jonathan Freaney, Varun Sood, Abbey Thompson, Agustina D'Urso, Curt M Horvath, Jason H Brickner   +6 more
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Transcriptional program of memory B cell subsets.

, 2016
Transcriptional program of memory B cell subsets.
Marie-Pierre Mailhé (3361190), Sylvie Garcia (249541), Marie Anson (3361187), Emmanuel Donnadieu (257531), François Huetz (3361178), Antonio A. Freitas (3361181), Inês Amado (3361184)   +6 more
core   +1 more source