Results 1 to 10 of about 348,372 (162)
Epigenetics-targeted drugs: current paradigms and future challenges
Signal Transduction and Targeted TherapyEpigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation.
Xinbo Qiao, Wanlin Dai, Da Li
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Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
Nature Reviews Nephrology, 2019 The development and progression of diabetic kidney disease (DKD), a highly prevalent complication of diabetes mellitus, are influenced by both genetic and environmental factors.
Mitsuo Kato +2 more
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Epigenetics in Human Obesity and Type 2 Diabetes
Cell Metabolism, 2019 Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated processes, and disruption of this balance may cause several pathologies and contribute to ...
Charlotte Ling, Tina Ronn
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The impact of cellular metabolism on chromatin dynamics and epigenetics
Nature Cell Biology, 2017 The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation ...
Michael A Reid +2 more
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Advances in epigenetics link genetics to the environment and disease
Nature, 2019 Giacomo Cavalli +2 more
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Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Signal Transduction and Targeted Therapy, 2023 Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others.
Yan-Lin Wu +9 more
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How epigenetics impacts on human diseases.
European journal of internal medicine, 2023 Epigenetics is a rapidly growing field of biology that studies the changes in gene expression that are not due to alterations in the DNA sequence but rather the chemical modifications of DNA and its associated proteins.
A. Farsetti, B. Illi, C. Gaetano
semanticscholar +1 more source
Indian Journal of Medical and Paediatric Oncology, 2020 Historically, cancer is known to be a genetic disease. It is now realized that it involves epigenetic abnormalities along with genetic alterations. Epigenetics is an extra layer of instruction that lies upon DNA and controls how the genes are read and ...
Ravi Jaiswal, Esha Jafa
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Cancer epigenetics in clinical practice
Ca, 2022 Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute to the acquisition of hallmark tumor capabilities by ...
V. Davalos, M. Esteller
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The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection
Viruses, 2020 Epigenetics is a versatile player in manipulating viral infection and a potential therapeutic target for the treatment of viral-induced diseases. Both epigenetics and metabolism are crucial in establishing a highly specific transcriptional network, which
Yonggang Pei, Erle S. Robertson
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