Results 21 to 30 of about 224,057 (304)
Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease [PDF]
, 2015 Many different environmental factors (nutrients, pollutants, chemicals, physical activity, lifestyle, physical and mental stress) can modulate epigenetic markers in the developing and adult organism. Epigenetics, in turn, can cause and is associated with
FUSO, ANDREA +2 more
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Genes to Cells, 2012 Induced pluripotent stem (iPS) cells have provided a rational means of obtaining histo‐compatible tissues for ‘patient‐specific’ regenerative therapies (Hanna et al. 2010; Yamanaka & Blau 2010). Despite the obvious potential of iPS cell‐based therapies, there are certain problems that must be overcome before these therapies can become safe and ...
Manukyan, Maria, Singh, Prim B
openaire +2 more sources
Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
doaj +1 more source
Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]
, 2014 BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari +55 more
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Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
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Molecular Cell, 2001 In the November 15 issue of Nature, report that disruption of histone methylation in the fungus Neurospora crassa results in the elimination of DNA methylation. This demonstrates that chromatin structure can pattern DNA methylation and suggests that different epigenetic layers engage in complex crosstalk.
Ben-Porath, Ittai, Cedar, Howard
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From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]
, 2018 Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R. +13 more
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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
Epigenetics & Chromatin, 2017 Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation ...
Ksenia Skvortsova +6 more
doaj +1 more source
Role of epigenetics in cardiovascular diseases: An out and out check
Intelligent Pharmacy, 2023 Epigenetics is a rapidly growing field that deals with the study of heritable changes in gene expression that occur without a change in DNA sequence.
Rufaida Wasim +5 more
doaj +1 more source
Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
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