Results 1 to 10 of about 1,977,316 (301)

Predictors and consequences of global DNA methylation in cord blood and at three years. [PDF]

PLoS ONE, 2013
DNA methylation changes have been implicated in many common chronic diseases leading to the hypothesis that environmental and age-related DNA methylation changes within individuals are involved in disease etiology.
Julie B Herbstman, Shuang Wang, Frederica P Perera, Sally A Lederman, Julia Vishnevetsky, Andrew G Rundle, Lori A Hoepner, Lirong Qu, Deliang Tang   +8 more
doaj   +1 more source

Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies

Neuropsychopharmacology Reports, 2019
Introduction Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene‐environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in cohort studies ...
Yui Murata, Ayaka Fujii, Sho Kanata, Shinya Fujikawa, Tempei Ikegame, Yutaka Nakachi, Zhilei Zhao, Seiichiro Jinde, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto   +10 more
doaj   +1 more source

Minimal evidence for consistent changes in maize DNA methylation patterns following environmental stress.

Frontiers in Plant Science, 2015
DNA methylation is a chromatin modification that is sometimes associated with epigenetic regulation of gene expression. As DNA methylation can be reversible at some loci, it is possible that methylation patterns may change within an organism that is ...
Steven R Eichten, Nathan M Springer
doaj   +1 more source

DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma

Frontiers in Cell and Developmental Biology, 2022
Growing evidence links DNA methylation to tumor immunity. The impact of DNA methylation (5 mC) on the microenvironment surrounding tumors and immunotherapy remains to be clarified. Through clustering gene expression of 20 DNA methylation regulators, this
Xinyu Yu, Yijun Che, Weiyang Li, Peng Zhang, Yunhu Yu, Yunhu Yu, Jialin Chen, Ting Gong, Fang Cao   +8 more
doaj   +1 more source

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Cell Reports, 2019
Summary: Altered DNA methylation plays an important role in the onset and progression of kidney disease. However, little is known about how the changes arise in disease states.
Akihito Hishikawa, Kaori Hayashi, Takaya Abe, Mari Kaneko, Hideki Yokoi, Tatsuhiko Azegami, Mari Nakamura, Norifumi Yoshimoto, Takeshi Kanda, Yusuke Sakamaki, Hiroshi Itoh   +10 more
doaj   +1 more source

Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates.

Frontiers in Physiology, 2014
DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level,
Guillaume eRiviere, Guillaume eRiviere
doaj   +1 more source

Sex-specific variations in global DNA methylation levels with age: a population-based exploratory study from North India

Frontiers in Genetics, 2023
Purpose: Aging is one of the most important risk factors for a number of human diseases. Epigenetic alterations, including changes in DNA methylation patterns, have been reported to be one of the hallmarks of aging. Being a malleable process, the role of
Anshika Kaushik, Vineet Chaudhary, Imnameren Longkumer, Kallur Nava Saraswathy, Sonal Jain   +4 more
doaj   +1 more source

Genome-wide negative feedback drives transgenerational DNA methylation dynamics in Arabidopsis. [PDF]

PLoS Genetics, 2015
Epigenetic variations of phenotypes, especially those associated with DNA methylation, are often inherited over multiple generations in plants. The active and inactive chromatin states are heritable and can be maintained or even be amplified by positive ...
Tasuku Ito, Yoshiaki Tarutani, Taiko Kim To, Mohamed Kassam, Evelyne Duvernois-Berthet, Sandra Cortijo, Kazuya Takashima, Hidetoshi Saze, Atsushi Toyoda, Asao Fujiyama, Vincent Colot, Tetsuji Kakutani   +11 more
doaj   +1 more source

Role of genetic and environmental factors in DNA methylation of lipid metabolism

Genes and Diseases, 2018
A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate ...
Zhen He, Rong Zhang, Feng Jiang, Wenjing Hou, Cheng Hu   +4 more
doaj   +1 more source

A simple modification to the luminometric methylation assay to control for the effects of DNA fragmentation

BioTechniques, 2015
Variations in DNA methylation have been implicated in a number of disorders. Changes in global DNA methylation levels have long been associated with various types of cancer.
Elif Aysimi Duman, Skirmantas Kriaucionis, John J. Dunn, Eli Hatchwell   +3 more
doaj   +1 more source