Results 21 to 30 of about 349,927 (269)
DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma
Frontiers in Cell and Developmental Biology, 2022 Growing evidence links DNA methylation to tumor immunity. The impact of DNA methylation (5 mC) on the microenvironment surrounding tumors and immunotherapy remains to be clarified. Through clustering gene expression of 20 DNA methylation regulators, this
Xinyu Yu +8 more
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Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies
Neuropsychopharmacology Reports, 2019 Introduction Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene‐environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in cohort studies ...
Yui Murata +10 more
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Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes
Cell Reports, 2019 Summary: Altered DNA methylation plays an important role in the onset and progression of kidney disease. However, little is known about how the changes arise in disease states.
Akihito Hishikawa +10 more
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DNA Methylation in Osteoarthritis [PDF]
Current Genomics, 2015 Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by degradation and calcification of articular cartilage. Presently, no effective treatment other than pain relief exists and patients ultimately need to undergo replacement surgery of the affected joint.
Hollander, W. den, Meulenbelt, I.
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Frontiers in Plant Science, 2015 DNA methylation is a chromatin modification that is sometimes associated with epigenetic regulation of gene expression. As DNA methylation can be reversible at some loci, it is possible that methylation patterns may change within an organism that is ...
Steven R Eichten, Nathan M Springer
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Frontiers in Genetics, 2023 Purpose: Aging is one of the most important risk factors for a number of human diseases. Epigenetic alterations, including changes in DNA methylation patterns, have been reported to be one of the hallmarks of aging. Being a malleable process, the role of
Anshika Kaushik +4 more
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BioTechniques, 2015 Variations in DNA methylation have been implicated in a number of disorders. Changes in global DNA methylation levels have long been associated with various types of cancer.
Elif Aysimi Duman +3 more
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Methylation of chromatin DNA [PDF]
Nucleic Acids Research, 1976 E. coli DNA methylase has been used to methylate chromatin DNA in vitro. At saturation only 50% of the chromatin DNA becomes methylated. The methylated regions of chromatin correspond to that fraction of the chromatin which is sensitive to staphylococcal nuclease.
S, Bloch, H, Cedar
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Aging and DNA methylation [PDF]
BMC Biology, 2015 In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is ...
Jung, Marc, Pfeifer, Gerd P
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Role of genetic and environmental factors in DNA methylation of lipid metabolism
Genes and Diseases, 2018 A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate ...
Zhen He +4 more
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