Results 21 to 30 of about 1,977,316 (301)

Influence of genetic background and tissue types on global DNA methylation patterns. [PDF]

PLoS ONE, 2010
Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively ...
Howard H Yang, Nan Hu, Chaoyu Wang, Ti Ding, Barbara K Dunn, Alisa M Goldstein, Philip R Taylor, Maxwell P Lee   +7 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

Epigenetics & Chromatin, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding mammalian genes was believed to be at least five times greater than the actual number, and when it was ...
John R. Edwards, Olya Yarychkivska, Mathieu Boulard, Timothy H. Bestor   +3 more
openaire   +5 more sources

Genetic and DNA methylation changes in cotton (Gossypium) genotypes and tissues. [PDF]

PLoS ONE, 2014
In plants, epigenetic regulation is important in normal development and in modulating some agronomic traits. The potential contribution of DNA methylation mediated gene regulation to phenotypic diversity and development in cotton was investigated between
Kenji Osabe, Jenny D Clement, Frank Bedon, Filomena A Pettolino, Lisa Ziolkowski, Danny J Llewellyn, E Jean Finnegan, Iain W Wilson   +7 more
doaj   +1 more source

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

Frontiers in Immunology, 2021
Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years.
Wanhai Qin, Brendon P. Scicluna, Brendon P. Scicluna, Tom van der Poll, Tom van der Poll   +4 more
doaj   +1 more source

Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. [PDF]

PLoS ONE, 2010
Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer.
Stella Tommasi, Sang-in Kim, Xueyan Zhong, Xiwei Wu, Gerd P Pfeifer, Ahmad Besaratinia   +5 more
doaj   +1 more source

Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta. [PDF]

PLoS ONE, 2014
A small number of recent reports have suggested that altered placental DNA methylation may be associated with early onset preeclampsia. It is important that further studies be undertaken to confirm and develop these findings.
Tianjiao Chu, Kimberly Bunce, Patricia Shaw, Varsha Shridhar, Andrew Althouse, Carl Hubel, David Peters   +6 more
doaj   +1 more source

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source

Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes

Frontiers in Physiology, 2014
DNA methylation patterns and functions are variable across invertebrate taxa. In order to provide a better understanding of DNA methylation in the Pacific oyster (Crassostrea gigas), we characterized the genome-wide DNA methylation profile in male gamete
Claire E. Olson, Steven B. Roberts
doaj   +1 more source

DNA methylation analysis

Swiss Medical Weekly, 2013
DNA methylation, the addition of a methyl group to cytosines and adenosines, regulates gene expression on a level that is usually referred to as epigenetic, that is, stably maintained during cell divisions. In humans, aberrant DNA methylation is associated with several malignancies, including cancer and so-called imprinting disorders, making it an ...
von Känel T, Huber AR
openaire   +4 more sources

DNA methylation and cancer [PDF]

Oncogene, 2002
There is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization that the 'histone code', which involves the post-translational modification of histones and which has important ramifications for chromatin structure, may be ...
openaire   +3 more sources