Results 11 to 20 of about 1,977,316 (301)

Apoptosis and DNA Methylation [PDF]

Cancers, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity.
Meng, Huan X, Hackett, James A, Nestor, Colm, Dunican, Donncha S, Madej, Monika, Reddington, James P, Pennings, Sari, Harrison, David J, Meehan, Richard R   +8 more
openaire   +6 more sources

DNA methylation either antagonizes or promotes Polycomb recruitment at transposable elements in Arabidopsis [PDF]

Nature Communications
Transposable elements (TEs) are usually silenced by DNA methylation and H3K9me2, but in the absence of DNA methylation they can instead acquire the Polycomb-associated mark H3K27me3. Here, we initially set out to test whether DNA methylation and H3K27me3
Valentin Hure, Maghnia Kawter Elmir, Florence Piron-Prunier, Raphaël Guérois, Angélique Déléris   +4 more
doaj   +2 more sources

Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing [PDF]

Journal of Epigenetics, 2022
Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection.
Samina Gul, Tang Wenru
doaj   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Dominguez Salas, Paula, Dominguez-Salas, P, Prentice, AM, Sophie E. Moore, Cox, SE, Dominguez-Salas, Paula, Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Andrew M. Prentice, Moore, SE, Moore, Sophie E, Hennig, BJ, Cox, Sharon E, Prentice, Andrew M., Moore, Sophie E., Hennig, Branwen J., Branwen J. Hennig, Sharon E. Cox, Cox, Sharon E.   +19 more
core   +3 more sources

Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. [PDF]

PLoS ONE, 2011
DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis.
Chun-Ming Wong, Carmen Chak-Lui Wong, Yeung-Lam Ng, Sandy Leung-Kuen Au, Frankie Chi-Fat Ko, Irene Oi-Lin Ng   +5 more
doaj   +1 more source

Computational analysis of CpG site DNA methylation [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Epigenetics is the study of factors that can change DNA and passed to next generation without change to DNA sequence.
Ghorbani, Mohammadmersad
core   +7 more sources

DNA Methylation [PDF]

EcoSal Plus, 2009
The DNA of Escherichia coli contains 19,120 6-methyladenines and 12,045 5-methylcytosines in addition to the four regular bases, and these are formed by the postreplicative action of three DNA methyltransferases. The majority of the methylated bases are formed by the Dam and Dcmmethyltransferases encoded by the
Marinus, Martin G., Løbner-Olesen, Anders   +1 more
openaire   +5 more sources

DNA methylation in follicular lymphoma [PDF]

, 2010
PhDFollicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival.
Ó Riain, Ciarán Liam
core   +4 more sources

Methylation of DNA [PDF]

The Journal of General Physiology, 1966
The methylated bases of DNA are formed by the transfer of the methyl group from S-adenosylmethionine to a polynucleotide acceptor. This transfer is catalyzed by highly specific enzymes which recognize a limited number of available sites in the DNA. The mechanism for the recognition is presently unknown.
M, Gold, M, Gefter, R, Hausmann, J, Hurwitz   +3 more
openaire   +2 more sources

SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. [PDF]

PLoS ONE, 2010
DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have
Dawei Gou, Monica Rubalcava, Silvia Sauer, Felipe Mora-Bermúdez, Hediye Erdjument-Bromage, Paul Tempst, Elisabeth Kremmer, Frank Sauer   +7 more
doaj   +1 more source