Results 31 to 40 of about 349,927 (269)
PLoS Genetics, 2020 Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa that ...
Fredrika Åsenius +9 more
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DNA methylation in insects [PDF]
Insect Molecular Biology, 2004 Abstract Cytosine DNA methylation has been demonstrated in numerous eukaryotic organisms and has been shown to play an important role in human disease. The function of DNA methylation has been studied extensively in vertebrates, but establishing its primary role has proved difficult and controversial.
Field, L. M. +3 more
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Parenting stress and DNA methylation among African Americans in the InterGEN Study
Journal of Clinical and Translational Science, 2017 IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described.
Michelle L. Wright +6 more
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Cell Reports, 2017 Summary: DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How
Nicolas Veland +8 more
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Decreased DNA methylation of a CpG site in the HBAP1 gene in plasma DNA from pregnant women. [PDF]
PLoS ONE, 2018 OBJECTIVE:The objective of this study is to identify potential CpG site(s) or DNA methylation pattern(s) in the pseudo α-globin 1 gene (HBAP1 gene), the gene which locates in α-thalassemia-1 deletion mutation, to differentiate plasma DNA between pregnant
Tanapat Pangeson +3 more
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Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. [PDF]
PLoS ONE, 2015 Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription, of the insulin promoter, particularly the cAMP response element, is increased in diabetes ...
Kota Ishikawa +14 more
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Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns
Frontiers in Microbiology, 2021 DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by transferring a methyl group to DNA. The genetic variation in DNMTs results in differential DNA methylation patterns associated with various biological processes.
Yu-Shin Nai +6 more
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DNA methylation in fibrosis [PDF]
European Journal of Cell Biology, 2016 Fibrosis is characterised by an exuberant wound healing response and the major cell type responsible is the myofibroblast. The myofibroblast is typified by excessive ECM production and contractile activity and is demarcated by alpha-smooth muscle actin expression. What has recently come to light is that the activation of the fibroblast to myofibroblast
Dowson, Christopher, O'Reilly, Steven
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Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. [PDF]
PLoS Genetics, 2008 At the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27 trimethylation are mutually exclusive,
Anders M Lindroth +11 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver +25 more
wiley +1 more source