Results 51 to 60 of about 1,977,316 (301)

DNA Methylation in Zebrafish [PDF]

, 2011
DNA methylation is crucial for normal development and cellular differentiation in many large-genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently emerged as a powerful system for the study of DNA methylation, especially in the context of development.
Mary G, Goll, Marnie E, Halpern
openaire   +2 more sources

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress [PDF]

, 2012
Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (OXTR) and brain-derived ...
Dempster, E., Dempster, Emma, Unternaehrer, Eva, Lieb, Roselind, Meyer, A. H., Unternaehrer, E., Luers, P., Mill, J., Staehli, S., Hellhammer, D. H., Meyer, Andrea H., Lieb, R., Meinlschmidt, G., Staehli, Simon, Mill, John, Hellhammer, Dirk H., Meinlschmidt, Gunther, Luers P, Meinlschmidt G, Lieb R, Meyer AH, Dempster E, Staehli S, Hellhammer DH, Mill J, Unternaehrer E   +25 more
core   +1 more source

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

eLife, 2017
DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Dongming Li, Ana Marie S Palanca, So Youn Won, Lei Gao, Ying Feng, Ajay A Vashisht, Li Liu, Yuanyuan Zhao, Xigang Liu, Xiuyun Wu, Shaofang Li, Brandon Le, Yun Ju Kim, Guodong Yang, Shengben Li, Jinyuan Liu, James A Wohlschlegel, Hongwei Guo, Beixin Mo, Xuemei Chen, Julie A Law   +20 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis [PDF]

, 2015
A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear.
Robert J. Schmitz, Chad E. Niederhuth, Ooi, Steen KT, Stathopoulou, A, Richard G. Jenner, Steen K.T. Ooi, de Rooij, Dirk G, Tuna, Salih, Vlachogiannis, Georgios, Niederhuth, CE, Viiri, Keijo, Niederhuth, Chad E, Schmitz, RJ, Jenner, Richard G,, Vlachogiannis, G, Keijo Viiri, Tuna, S, Ooi, SK, Stathopoulou, Athanasia, Jenner, RG, de Rooij, DG, Dirk G. de Rooij, Schmitz, Robert J, Athanasia Stathopoulou, Salih Tuna, Viiri, K, Georgios Vlachogiannis   +26 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Psychosocial stress experience and DNA methylation in humans - implications for stress-adaptation and -resilience [PDF]

, 2014
: Background: Psychosocial stress, especially early in life, is a risk factor for mental disorders. Recent evidence suggests that stress-related changes in epigenetic patterns, including DNA methylation, could mediate this association. Aim: to examine a
Unternaehrer, Eva
core   +1 more source

Regulated DNA Methylation and the Circadian Clock: Implications in Cancer

Biology, 2014
Since the cloning and discovery of DNA methyltransferases (DNMT), there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease.
Tammy M. Joska, Riasat Zaman, William J. Belden   +2 more
doaj   +1 more source

Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns

Frontiers in Microbiology, 2021
DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by transferring a methyl group to DNA. The genetic variation in DNMTs results in differential DNA methylation patterns associated with various biological processes.
Yu-Shin Nai, Yu-Shin Nai, Yu-Chun Huang, Yu-Chun Huang, Yu-Chun Huang, Ming-Ren Yen, Pao-Yang Chen   +6 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source