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Methylation of chromatin DNA [PDF]
Nucleic Acids Research, 1976 E. coli DNA methylase has been used to methylate chromatin DNA in vitro. At saturation only 50% of the chromatin DNA becomes methylated. The methylated regions of chromatin correspond to that fraction of the chromatin which is sensitive to staphylococcal nuclease.
S, Bloch, H, Cedar
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Aging and DNA methylation [PDF]
BMC Biology, 2015 In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is ...
Jung, Marc, Pfeifer, Gerd P
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Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]
, 2011 : Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE +4 more
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Role of genetic and environmental factors in DNA methylation of lipid metabolism
Genes and Diseases, 2018 A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate ...
Zhen He +4 more
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Parenting stress and DNA methylation among African Americans in the InterGEN Study
Journal of Clinical and Translational Science, 2017 IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described.
Michelle L. Wright +6 more
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Frontiers in Chemistry, 2023 DNA methylation plays an important physiological function in cells, and environmental changes result in fluctuations in DNA methylation levels. Metal ions have become both environmental and health concerns, as they have the potential to disrupt the ...
Shan Liu +4 more
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In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]
, 2019 BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker +47 more
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Cell Reports, 2017 Summary: DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How
Nicolas Veland +8 more
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Decreased DNA methylation of a CpG site in the HBAP1 gene in plasma DNA from pregnant women. [PDF]
PLoS ONE, 2018 OBJECTIVE:The objective of this study is to identify potential CpG site(s) or DNA methylation pattern(s) in the pseudo α-globin 1 gene (HBAP1 gene), the gene which locates in α-thalassemia-1 deletion mutation, to differentiate plasma DNA between pregnant
Tanapat Pangeson +3 more
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DNA methylation in insects [PDF]
Insect Molecular Biology, 2004 Abstract Cytosine DNA methylation has been demonstrated in numerous eukaryotic organisms and has been shown to play an important role in human disease. The function of DNA methylation has been studied extensively in vertebrates, but establishing its primary role has proved difficult and controversial.
Field, L. M. +3 more
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