Results 31 to 40 of about 348,521 (309)
Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups
Epigenetics & Chromatin, 2019 Background ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-coding RNA to remodel the chromatin ...
Katherine A. Giles +9 more
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Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
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Epigenetics and Evolution [PDF]
Integrative and Comparative Biology, 2014 Epigenetic mechanisms traditionally have been studied in the domains of development and disease, but they may also play important roles in ecological and evolutionary processes. In this article, we revisit historical as well as recent studies that indicate significant impacts of epigenetic processes on evolution.
I, Mendizabal +3 more
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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
Epigenetics & Chromatin, 2017 Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation ...
Ksenia Skvortsova +6 more
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Role of epigenetics in cardiovascular diseases: An out and out check
Intelligent Pharmacy, 2023 Epigenetics is a rapidly growing field that deals with the study of heritable changes in gene expression that occur without a change in DNA sequence.
Rufaida Wasim +5 more
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Cancer Epigenetics, Tumor Immunity, and Immunotherapy.
Trends in Cancer, 2020 Epigenetic mechanisms, including DNA methylation, histone post-translational modifications, and chromatin structure regulation, are critical for the interactions between tumor and immune cells.
Jian Cao, Qin Yan
semanticscholar +1 more source
Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
openaire +5 more sources
Nature Communications, 2020 Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka +18 more
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Teaching & Learning Inquiry: The ISSOTL Journal, 2020 Mental health researchers emphasize the importance of practitioner understanding of biology-environment interplay. Accordingly, our goal of the study described in this article was to understand students’ preconceptions and misconceptions about biological
Kate E. Snyder +3 more
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Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification
Clinical Epigenetics, 2020 Machine learning is a sub-field of artificial intelligence, which utilises large data sets to make predictions for future events. Although most algorithms used in machine learning were developed as far back as the 1950s, the advent of big data in ...
S. Rauschert +5 more
semanticscholar +1 more source