Results 1 to 10 of about 30,324 (266)
BMC Gastroenterology, 2021 Background Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis, primarily due to failed early detection. HCC screening is recommended among individuals with cirrhosis using biannual abdominal ultrasound, for earlier ...
Jörn Lewin +13 more
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Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments
BMC Genomics, 2023 Chromatin immunoprecipitation (ChIP) is an antibody-based approach that is frequently utilized in chromatin biology and epigenetics. The challenge in experimental variability by unpredictable nature of usable input amounts from samples and undefined ...
Ariel Caride +11 more
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Cell Death and Disease, 2023 Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their ...
Ilaria Petraroia +10 more
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Scientific Reports, 2023 Menstruation is a natural phenomenon for every female, starting from adolescents to menopausal age. Any disturbances in menstrual patterns can eventually affect one’s physical as well as psychological health which in turn hamper the quality of life of ...
Shrinjana Dhar +2 more
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BMC Research Notes, 2019 Objective DNA methylation analysis via real-time PCR or other analytical techniques requires purified bisulfite converted DNA. We report on an automated high throughput solution for DNA extraction, bisulfite-conversion, and purification of 96 samples ...
Sebastian Rausch +4 more
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RNA N6-methyladenosine methylation and skin diseases
Autoimmunity, 2023 Skin diseases are global health issues caused by multiple pathogenic factors, in which epigenetics plays an invaluable role. Post-transcriptional RNA modifications are important epigenetic mechanism that regulate gene expression at the genome-wide level.
Yaqin Yu +6 more
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Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Nature Communications, 2022 Discoid lupus erythematosus (DLE) and systemic LE (SLE) can present as cutaneous lesions. Here the authors characterise an scRNA dataset of cutaneous lesions from these patients and compare these to healthy controls showing differential immune cell ...
Meiling Zheng +16 more
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Brazilian Archives of Biology and Technology, 2022 DNA methylation and Histone are the main constituents to oversee the stable maintenance of cellular phenotypes. Any abnormalities in these components could cause cancer development and, therefore, must be potentially diagnostic.
Wakar Ahmad +3 more
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Enhanced JBrowse plugins for epigenomics data visualization
BMC Bioinformatics, 2018 Background New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications.
Brigitte T. Hofmeister +1 more
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Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq
BMC Genomics, 2019 Background Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are a major ...
Jian Zhong +10 more
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