Results 31 to 40 of about 35,782 (293)
“Same difference”: comprehensive evaluation of four DNA methylation measurement platforms
Epigenetics & Chromatin, 2018 Background DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, imprinting, and other biological ...
Thadeous J. Kacmarczyk +6 more
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Genome Medicine, 2021 Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
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Nature Reviews Microbiology, 2019 In all domains of life, genomes contain epigenetic information superimposed over the nucleotide sequence. Epigenetic signals control DNA-protein interactions and can cause phenotypic change in the absence of mutation. A nearly universal mechanism of epigenetic signalling is DNA methylation.
María A. Sánchez-Romero +1 more
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Current Opinion in Nephrology and Hypertension, 2020 Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease.Reversible DNA and histone modifications influence chromatin accessibility and can be measured by ...
Parker C, Wilson +2 more
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Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
BMC Genomics, 2017 Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong +9 more
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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Epigenomics of Hypertension [PDF]
Seminars in Nephrology, 2013 Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Mingyu, Liang +4 more
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Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics. [PDF]
, 2014 The use of tumour xenografts is a well-established research tool in cancer genomics but has not yet been comprehensively evaluated for cancer ...
Ross, MT +39 more
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Immune repertoire: Revealing the “real-time” adaptive immune response in autoimmune diseases
Autoimmunity, 2021 The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life.
Meiyu Wu +3 more
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The allure of the epigenome [PDF]
Genome Biology, 2012 The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
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