Results 31 to 40 of about 33,317 (303)

Epigenomics and the kidney

Current Opinion in Nephrology and Hypertension, 2020
Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease.Reversible DNA and histone modifications influence chromatin accessibility and can be measured by ...
Parker C, Wilson, Nicolas, Ledru, Benjamin D, Humphreys   +2 more
openaire   +3 more sources

Environmental Epigenomes

Epigenomes, 2023
Research in epigenetics has dramatically risen during the last decade to include aspects of environmental biology. However, many questions remain regarding the effects of environmental stressors on the epigenome, incorporating the particular role of epigenetic mechanisms in the adaptation and evolution of organisms in changing environments. Epigenetics
Bambarendage P. U. Perera, Frédéric Silvestre   +1 more
openaire   +4 more sources

Epigenetics and Epigenomics [PDF]

, 2014
The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current ...

core   +1 more source

Epigenetics and Epigenomics: the future of nutritional interventions? [PDF]

, 2017
Epigenetics and Epigenomics: the future of nutritional ...
Beth Hussey (1248618), Sarabjit Mastana (1249860), Martin Lindley (1255941)   +2 more
core   +2 more sources

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

BMC Genomics, 2017
Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong, Zhenqing Ye, Samuel W. Lenz, Chad R. Clark, Adil Bharucha, Gianrico Farrugia, Keith D. Robertson, Zhiguo Zhang, Tamas Ordog, Jeong-Heon Lee   +9 more
doaj   +1 more source

Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Genome Medicine, 2021
Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
doaj   +1 more source

Rewriting the Epigenome [PDF]

Cell, 2012
The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
Carone, Benjamin R., Rando, Oliver J.
openaire   +2 more sources

Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics. [PDF]

, 2014
The use of tumour xenografts is a well-established research tool in cancer genomics but has not yet been comprehensively evaluated for cancer ...
Ross, MT, Paul Guilhamon, Haybaeck, J, Keilholz, U, Presneau, Nadège, Ulrich Keilholz, Gareth A Wilson, Johannes Haybaeck, Ross, M.T., Wilson, G.A., Nadege Presneau, Stephan Beck, Haybaeck, J., Presneau, N, Wilson, GA, Feber, A, Lee M Butcher, Dirk S Paul, Flanagan, AM, Mark T Ross, Paul, D.S., Paul, DS, Beck, S, Jens Hoffman, Butcher, L.M., Butcher, LM, Beck, S., Hoffman, J, Guilhamon, P, Feber, A., Keilholz, U., Andrew Feber, Adrienne M Flanagan, Guilhamon, P., Paul Guilhamon, Flanagan, A.M., Moritz Schütte, Schütte, M., Hoffman, J., Schütte, M   +39 more
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Epigenomics of Hypertension [PDF]

Seminars in Nephrology, 2013
Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Mingyu, Liang, Allen W, Cowley, David L, Mattson, Theodore A, Kotchen, Yong, Liu   +4 more
openaire   +2 more sources

m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus

Molecular Medicine, 2023
Background Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4+ T-cell activation and imbalanced effector T-cell differentiation play critical roles.
Shuang Lu, Xingyu Wei, Huan Zhu, Zhi Hu, Meiling Zheng, Jiali Wu, Cheng Zhao, Shuang Yang, Delong Feng, Sujie Jia, Hongjun Zhao, Ming Zhao   +11 more
doaj   +1 more source