Results 31 to 40 of about 36,855 (297)
Brazilian Archives of Biology and Technology, 2022 DNA methylation and Histone are the main constituents to oversee the stable maintenance of cellular phenotypes. Any abnormalities in these components could cause cancer development and, therefore, must be potentially diagnostic.
Wakar Ahmad +3 more
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“Same difference”: comprehensive evaluation of four DNA methylation measurement platforms
Epigenetics & Chromatin, 2018 Background DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, imprinting, and other biological ...
Thadeous J. Kacmarczyk +6 more
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Genome Medicine, 2021 Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
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Cell, 2012 The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
Carone, Benjamin R., Rando, Oliver J.
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Epigenetics and Epigenomics [PDF]
, 2014 The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current ...
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Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
BMC Genomics, 2017 Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong +9 more
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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Exploring the Ethics of Implementation of Epigenomics Technologies in Cancer Screening:A Focus Group Study [PDF]
, 2021 New epigenomics technologies are being developed and used for the detection and prediction of various types of cancer. By allowing for timely intervention or preventive measures, epigenomics technologies show promise for public health, notably in ...
Bunnik, Eline M. +3 more
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The allure of the epigenome [PDF]
Genome Biology, 2012 The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
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Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics. [PDF]
, 2014 The use of tumour xenografts is a well-established research tool in cancer genomics but has not yet been comprehensively evaluated for cancer ...
Ross, MT +39 more
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