Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]
, 2020 During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana +19 more
core +1 more source
Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]
, 2013 DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
core +7 more sources
A Time-driven Data Placement Strategy for a Scientific Workflow Combining Edge Computing and Cloud Computing [PDF]
, 2019 Compared to traditional distributed computing environments such as grids, cloud computing provides a more cost-effective way to deploy scientific workflows.
Chen, Jiaqing +6 more
core +1 more source
Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]
, 2020 Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
core +1 more source
The importance of detailed epigenomic profiling of different cell types within organs. [PDF]
, 2016 The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types ...
Borok, Zea +4 more
core +1 more source
RNA N6-methyladenosine methylation and skin diseases
Autoimmunity, 2023 Skin diseases are global health issues caused by multiple pathogenic factors, in which epigenetics plays an invaluable role. Post-transcriptional RNA modifications are important epigenetic mechanism that regulate gene expression at the genome-wide level.
Yaqin Yu +6 more
doaj +1 more source
Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Nature Communications, 2022 Discoid lupus erythematosus (DLE) and systemic LE (SLE) can present as cutaneous lesions. Here the authors characterise an scRNA dataset of cutaneous lesions from these patients and compare these to healthy controls showing differential immune cell ...
Meiling Zheng +16 more
doaj +1 more source
Brazilian Archives of Biology and Technology, 2022 DNA methylation and Histone are the main constituents to oversee the stable maintenance of cellular phenotypes. Any abnormalities in these components could cause cancer development and, therefore, must be potentially diagnostic.
Wakar Ahmad +3 more
doaj +1 more source
Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
core +1 more source
Enhanced JBrowse plugins for epigenomics data visualization
BMC Bioinformatics, 2018 Background New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications.
Brigitte T. Hofmeister +1 more
doaj +1 more source