Results 21 to 30 of about 36,855 (297)
Frontiers in Oncology, 2013 It is well known that Neuroblastoma (NB) patients whose tumors have an undifferentiated histology and a transcriptome enriched in cell cycle genes have a worse prognosis. This contrasts with the good prognoses of patients whose tumors have histologic evidence of differentiation and a transcriptome enriched in differentiation genes.
He, Stanley +3 more
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The Decade of the Epigenomes? [PDF]
Genes & Cancer, 2011 The beginning of this century was not only marked by the publication of the first draft of the human genome but also set off a decade of intense research on epigenetic phenomena. Apart from DNA methylation, it became clear that many other factors including a wide range of histone modifications, different shades of chromatin accessibility, and a vast ...
Martens, J.H.A. +2 more
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Regenerating the epigenome [PDF]
The EMBO Reports, 2011 The ability of some organisms to regenerate parts of their body has fascinated scientists for decades. The process of regeneration depends on the potential of certain cells to proliferate and contribute to the formation of new tissue. Organisms have evolved two strategies by which to achieve this: the maintenance of adult stem cells and the induction ...
Maria J, Barrero +1 more
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Epigenomes, 2023 Research in epigenetics has dramatically risen during the last decade to include aspects of environmental biology. However, many questions remain regarding the effects of environmental stressors on the epigenome, incorporating the particular role of epigenetic mechanisms in the adaptation and evolution of organisms in changing environments. Epigenetics
Bambarendage P. U. Perera +1 more
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Cell, 2007 Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and ...
Bernstein, Bradley E. +2 more
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Integrative Epigenomics: Bioinformatics Strategies for Multi-Omics Data Analysis in Health and Disease. [PDF]
EpigenomesBackground: Epigenomics has emerged as an essential field in modern molecular biology, providing a critical layer of gene regulation. DNA methylation, histone modifications and alterations to the chromatin accessibility of DNA have been widely associated
Baruri S, Batra L, Adhikari S, El-Baz A.
europepmc +2 more sources
Clinical epigenomics for cardiovascular disease: Diagnostics and therapies [PDF]
, 2021 The study of epigenomics has advanced in recent years to span the regulation of a single genetic locus to the structure and orientation of entire chromosomes within the nucleus.
Thomas M. Vondriska +3 more
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Epigenomics of Hypertension [PDF]
Seminars in Nephrology, 2013 Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Mingyu, Liang +4 more
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PEREpigenomics Profile Explorer of Roadmap Epigenomics data
, 2019 PEREpigenomics Profile Explorer of Roadmap Epigenomics data.
Devailly, Guillaume
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The pathological role of B cells in systemic lupus erythematosus: From basic research to clinical
Autoimmunity, 2020 Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life.
Yu Feng +3 more
doaj +1 more source