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Genomics and epigenomics [PDF]
The Journal of Headache and Pain, 2015 Migraine with (MA) and without aura (MO) is a common brain disorder that affects 15% of the general population. Genetic studies on twins have shown that MA and MO heritability spans between 50% and 60%[1]. Despite the high degree of heritability the genetic basis of MA and MO has not been elucidated and on the whole their etiology is far from being ...
Garagnani P. +8 more
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Nature Communications, 2018 Over the past decade, remarkable breakthroughs in our understanding of epigenetic biology have coincided with an increased public interest in the impact of diet and lifestyle choices on health. It is well established that a balanced diet enhances life expectancy and helps to prevent or treat certain diseases, such as obesity, diabetes, cancer, and ...
Yi Zhang, Tatiana G. Kutateladze
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The pathological role of B cells in systemic lupus erythematosus: From basic research to clinical
Autoimmunity, 2020 Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life.
Yu Feng +3 more
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Genome Medicine, 2021 Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
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“Same difference”: comprehensive evaluation of four DNA methylation measurement platforms
Epigenetics & Chromatin, 2018 Background DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, imprinting, and other biological ...
Thadeous J. Kacmarczyk +6 more
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Clinical and Translational Medicine, 2022 Background The aberrant differentiation of T follicular helper (Tfh) cells plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of regulating Tfh cells differentiation remains unclear.
Limin Liu +11 more
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Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
BMC Genomics, 2017 Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong +9 more
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Current Opinion in Nephrology and Hypertension, 2020 Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease.Reversible DNA and histone modifications influence chromatin accessibility and can be measured by ...
Parker C, Wilson +2 more
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Cell, 2012 The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
Carone, Benjamin R., Rando, Oliver J.
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Immune repertoire: Revealing the “real-time” adaptive immune response in autoimmune diseases
Autoimmunity, 2021 The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life.
Meiyu Wu +3 more
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