Results 41 to 50 of about 36,855 (297)

Quality control and evaluation of plant epigenomics data [PDF]

, 2021
Epigenomics is the study of molecular signatures associated with discrete regions within genomes, many of which are important for a wide range of nuclear processes. The ability to profile the epigenomic landscape associated with genes, repetitive regions,
Brady, Siobhan M, Zhang, Xuan, Chen, Xuemei, Megraw, Molly, Marand, A., Meyers, Blake C, Chen, X., Schmitz, R., Zhang, X., Axtell, Michael J, Meyers, B., Schmitz, Robert J, Mosher, R., Turck, Franziska, Megraw, M., Axtell, M., Zhong, X., Zhong, Xuehua, Marand, Alexandre P, Turck, F., Brady, S., Mosher, Rebecca A, Xuehua Zhong, Robert J Schmitz, Rebecca A Mosher, Siobhan M Brady, Franziska Turck, Michael J Axtell, Molly Megraw, Xuan Zhang, Blake C Meyers, Alexandre P Marand, Xuemei Chen   +32 more
core   +1 more source

Epigenomics of macrophages [PDF]

Immunological Reviews, 2014
SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
David, Gosselin, Christopher K, Glass
openaire   +2 more sources

The epigenomics of sarcoma

Nature Reviews Cancer, 2020
Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin ...
Benjamin A. Nacev, Kevin B. Jones, Andrew M. Intlekofer, Jamie S. E. Yu, C. David Allis, William D. Tap, Marc Ladanyi, Torsten O. Nielsen   +7 more
openaire   +3 more sources

Genomics and epigenomics [PDF]

The Journal of Headache and Pain, 2015
Migraine with (MA) and without aura (MO) is a common brain disorder that affects 15% of the general population. Genetic studies on twins have shown that MA and MO heritability spans between 50% and 60%[1]. Despite the high degree of heritability the genetic basis of MA and MO has not been elucidated and on the whole their etiology is far from being ...
Garagnani P., Terlizzi R., Cevoli S., Capellari S., Pierangeli G., Pirazzini C., Bacalini M. G., Franceschi C., Cortelli P.   +8 more
openaire   +2 more sources

Enhanced JBrowse plugins for epigenomics data visualization

, 2017
New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications.
Brigitte T. Hofmeister, Robert J. Schmitz   +1 more
core   +1 more source

m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus

Molecular Medicine, 2023
Background Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4+ T-cell activation and imbalanced effector T-cell differentiation play critical roles.
Shuang Lu, Xingyu Wei, Huan Zhu, Zhi Hu, Meiling Zheng, Jiali Wu, Cheng Zhao, Shuang Yang, Delong Feng, Sujie Jia, Hongjun Zhao, Ming Zhao   +11 more
doaj   +1 more source

Diet and the epigenome [PDF]

Nature Communications, 2018
Over the past decade, remarkable breakthroughs in our understanding of epigenetic biology have coincided with an increased public interest in the impact of diet and lifestyle choices on health. It is well established that a balanced diet enhances life expectancy and helps to prevent or treat certain diseases, such as obesity, diabetes, cancer, and ...
Yi Zhang, Tatiana G. Kutateladze
openaire   +3 more sources

New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine

Diagnostics
Following the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those ...
Pengtao Song, Biaoru Li
doaj   +1 more source

Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure

Nature Communications, 2022
While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente, Alexei Novoloaca, Vincent Cahais, Zainab Awada, Cyrille Cuenin, Natália Spitz, André Lopes Carvalho, Adriane Feijó Evangelista, Camila Souza Crovador, Rui Manuel Reis, Zdenko Herceg, Vinicius de Lima Vazquez, Akram Ghantous   +12 more
doaj   +1 more source

Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients

Autoimmunity, 2022
G protein-coupled receptor 183 (GPR183) has been indicated to mediate the migration and localisation of immune cells in T cell-dependent antibody responses.
Mingming Zhao, Yang Mei, Zhidan Zhao, Pengpeng Cao, Yue Xin, Yunkai Guo, Ming Yang, Haijing Wu   +7 more
doaj   +1 more source