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Epigenomes, 2023 Research in epigenetics has dramatically risen during the last decade to include aspects of environmental biology. However, many questions remain regarding the effects of environmental stressors on the epigenome, incorporating the particular role of epigenetic mechanisms in the adaptation and evolution of organisms in changing environments. Epigenetics
Bambarendage P. U. Perera +1 more
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PEREpigenomics Profile Explorer of Roadmap Epigenomics data
, 2019 PEREpigenomics Profile Explorer of Roadmap Epigenomics data.
Devailly, Guillaume
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Molecular Medicine, 2023 Background Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4+ T-cell activation and imbalanced effector T-cell differentiation play critical roles.
Shuang Lu +11 more
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Exploring the Ethics of Implementation of Epigenomics Technologies in Cancer Screening:A Focus Group Study [PDF]
, 2021 New epigenomics technologies are being developed and used for the detection and prediction of various types of cancer. By allowing for timely intervention or preventive measures, epigenomics technologies show promise for public health, notably in ...
Bunnik, Eline M., Bolt, Ineke L.L.E.
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Cell, 2007 Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and ...
Bernstein, Bradley E. +2 more
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Nature Reviews Cancer, 2020 Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin ...
Benjamin A. Nacev +7 more
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New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine
DiagnosticsFollowing the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those ...
Pengtao Song, Biaoru Li
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Nature Communications, 2022 While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente +12 more
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The Epigenome in Atherosclerosis [PDF]
, 2020 AbstractEmerging evidence suggests the growing importance of “nongenetic factors” in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account additional layers of biological regulation by “epi”-genetic changes.
Sarah, Costantino, Francesco, Paneni
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Developmental epigenomics and metabolic disease
, 2013 Organisms have evolved the processes of developmental plasticity to adjust their developmental trajectory in response to early life exposure to environmental cues.
Low, F.M. +8 more
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