Results 61 to 70 of about 53,444 (288)
Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers
Neoplasia: An International Journal for Oncology Research, 2005 The role of promoter methylation in the process of cancer cell metastasis has not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor, follistatin domain) gene was reported in human colon, gastric,
Matthias P.A. Ebert +9 more
doaj +1 more source
DanQ: a hybrid convolutional and recurrent deep neural network for quantifying the function of DNA sequences. [PDF]
, 2016 Modeling the properties and functions of DNA sequences is an important, but challenging task in the broad field of genomics. This task is particularly difficult for non-coding DNA, the vast majority of which is still poorly understood in terms of ...
Quang, Daniel, Xie, Xiaohui
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data
Genome BiologyEpigenetic heterogeneity is a fundamental property of biological systems and is recognized as a potential driver of tumor plasticity and therapy resistance.
Katherine Kelly +4 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients.
Ming Yang +12 more
doaj +1 more source
Epigenomics-Based Diagnostics [PDF]
Clinical Chemistry, 2010 The term “epigenetics,” first coined in 1942, refers to heritable traits of cells (over many rounds of cell division) that do not involve changes to the underlying DNA sequence. The 2 predominant epigenetic mechanisms are DNA methylation and histone modification.
Eleftherios P, Diamandis +4 more
openaire +2 more sources
Detection of Epigenomic Network Community Oncomarkers [PDF]
, 2016 In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their
Bartlett, Thomas E., Zaikin, Alexey
core +2 more sources
Arthritis Care &Research, Accepted Article.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Epigenomics in environmental health
Frontiers in Genetics, 2011 This review considers the emerging relationships between environmental factors and epigenetic alterations and the application of genome-wide assessments to better define these relationships.
Carmen J Marsit, Brock C Christensen
doaj +1 more source
Implementing Curcumin in Translational Oncology Research
Molecules, 2020 Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals.
Koraljka Gall Trošelj +5 more
doaj +1 more source