Results 61 to 70 of about 33,317 (303)
Nature Communications, 2021 Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis ...
Joschka Hey +9 more
doaj +1 more source
Ferroptosis Activation Contributes to the Formation of Skin Lesions in Psoriasis Vulgaris
Antioxidants, 2023 (1) Background: Ferroptosis is a newly coined form of programmed cell death marked by lethal accumulation of lipid peroxidation and ferrous iron overload.
Siying Li +8 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
NC and PSR with Epigenomics structure graph.
, 2019 NC and PSR with Epigenomics structure graph.
Yu Xin (412564) +3 more
core +1 more source
The Concepts of Epigenomics and Cell Epigenomes
, 2022 Genetics cannot solely explain genetic variations in humans and disease developments. We see varying differences in phenotypes and disease susceptibility in organisms that have the same genetic make-up, e.g., monozygotic twins and cloned animals.
Daştan, Taner, Baral, İnanç
core +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers
Neoplasia: An International Journal for Oncology Research, 2005 The role of promoter methylation in the process of cancer cell metastasis has not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor, follistatin domain) gene was reported in human colon, gastric,
Matthias P.A. Ebert +9 more
doaj +1 more source
PEREpigenomics Profile Explorer of Roadmap Epigenomics data
, 2019 PEREpigenomics Profile Explorer of Roadmap Epigenomics data.
Devailly, Guillaume
core +2 more sources
EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data
Genome BiologyEpigenetic heterogeneity is a fundamental property of biological systems and is recognized as a potential driver of tumor plasticity and therapy resistance.
Katherine Kelly +4 more
doaj +1 more source