Results 81 to 90 of about 33,317 (303)
The Breast JournalExposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer
Hamed Yasavoli-Sharahi +8 more
doaj +1 more source
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
PREDICTD PaRallel Epigenomics Data Imputation with Cloud-based Tensor Decomposition
, 2023 This dataset contains training data and the trained model parameters for PREDICTD, a 3D tensor decomposition-based model of the NIH Epigenomics Roadmap project data.
Durham, Timothy J +4 more
core +1 more source
Human Molecular Genetics, 2002 Research in cancer epigenomics is driven by the development of novel technologies and the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades, the search for cancer genes has focused on genetic defects that were used as tags for identification of these genes.
openaire +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Understanding epigenomics based on the rice model
, 2020 International audienceKey message The purpose of this paper provides a comprehensive overview of the recent researches on rice epigenomics, including DNA methylation, histone modifications, noncoding RNAs, and three-dimensional genomics.
Lu, Yue, M., Zhao, Yu, Zhou, Dao-Xiu
core +1 more source
How chronic inflammation fuels carcinogenesis as an environmental epimutagen
Discover OncologyChronic inflammation, induced by environmental and intrinsic factors, frequently leads to carcinogenesis. In inflammation-associated cancers, such as gastric, colon, and cervical cancers, an important role of epigenetic alterations has been implicated ...
Yu-Yu Liu +2 more
doaj +1 more source
eLife, 2022 A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
openaire +3 more sources
Vitamin D and the epigenome [PDF]
Frontiers in Physiology, 2014 Epigenetic mechanisms play a crucial role in regulating gene expression. The main mechanisms involve methylation of DNA and covalent modifications of histones by methylation, acetylation, phosphorylation, or ubiquitination. The complex interplay of different epigenetic mechanisms is mediated by enzymes acting in the nucleus.
Fetahu, Irfete S. +2 more
openaire +3 more sources
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source