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Epigenetics and depression [PDF]
Dialogues in Clinical Neuroscience, 2019 The risk for major depression is both genetically and environmentally determined. It has been proposed that epigenetic mechanisms could mediate the lasting increases in depression risk following exposure to adverse life events and provide a mechanistic ...
Signe Penner-Goeke, E. Binder
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Current Genomics, 2015 The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic patterns during aging) is the gradual decrease of global DNA methylation. Aging cells, different tissue types, as well as a variety of human diseases possess their own distinct DNA methylation profiles, although the functional impact of these is not always clear.
Sierra, Marta I. +2 more
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Epigenetics and Cancer: A Comprehensive Review
Asian Pacific Journal of Cancer Biology, 2023 Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out.
Ayush Pathak +2 more
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Computational epigenetics [PDF]
Bioinformatics, 2007 Abstract Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression.
Christoph Bock, Thomas Lengauer
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Cancer Communications, 2022 Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their metabolism to meet the high bioenergetic and biosynthetic demands for vigorous ...
T. Ge +6 more
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Nature Communications, 2020 The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in ...
Amanda Khoury +13 more
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Epigenetics of colorectal cancer: biomarker and therapeutic potential
Nature reviews: Gastroenterology & hepatology, 2020 Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a result of the stepwise accumulation of a series of genetic and epigenetic alterations in the normal colonic epithelium, leading to the development of colorectal ...
G. Jung +4 more
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Epigenetics for the 21st-Century Biology Student
Journal of Microbiology & Biology Education, 2019 Epigenetics, a rapidly emerging biological science, investigates changes in gene expression without any change to the primary DNA sequence. Epigenetics plays an important role in diverse areas, including nutritional sciences, psychology, and ...
Jonghoon Kang +3 more
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Genetics and Epigenetics in Asthma
International Journal of Molecular Sciences, 2021 Asthma is one of the most common respiratory disease that affects both children and adults worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly understood. As technology in genome sequencing progressed, scientific efforts were
P. Ntontsi +4 more
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Ethical implications of epigenetics in the era of personalized medicine
Clinical Epigenetics, 2022 Given the increasing research activity on epigenetics to monitor human diseases and its connection with lifestyle and environmental expositions, the field of epigenetics has attracted a great deal of interest also at the ethical and societal level.
J. Santaló, M. Berdasco
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