Results 81 to 90 of about 5,670,610 (287)

Nup98-dependent transcriptional memory is established independently of transcription

bioRxiv, 2020
Cellular ability to mount an enhanced transcriptional response upon repeated exposure to external cues has been termed transcriptional memory, which can be maintained epigenetically through cell divisions.
Pau Pascual-Garcia, Shawn C. Little, M. Capelson   +2 more
semanticscholar   +1 more source

Designing prosthetic memory [PDF]

Proceedings of the 2018 International Conference on Advanced Visual Interfaces, 2018
Audio recordings and the corresponding transcripts are often used as prosthetic memory (PM) after meetings and lectures. While current research is mainly developing novel features for prosthetic memory, less is known on how and why audio recordings and transcripts are used.
Sandra Trullemans, Payam Ebrahimi, Beat Signer   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems

Nature Communications
Despite its broad application in in vitro studies, the application of targeted protein degradation (TPD) to animal models faces considerable challenges. Here, we develop inducible and cell-type specific TPD systems in mice using two degron systems: Oryza
Motoi Yamashita, Chihiro Ogawa, Baihao Zhang, Tetsuro Kobayashi, Aneela Nomura, Clive Barker, Chengcheng Zou, Satoshi Yamanaka, Ken-ichiro Hayashi, Yoichi Shinkai, Kazuyo Moro, Sidonia Fargarasan, Koshi Imami, Jun Seita, Fumiyuki Shirai, Tatsuya Sawasaki, Masato T. Kanemaki, Ichiro Taniuchi   +17 more
doaj   +1 more source

Correction: Promoter-Bound p300 Complexes Facilitate Post-Mitotic Transmission of Transcriptional Memory

, 2014
Correction: Promoter-Bound p300 Complexes Facilitate Post-Mitotic Transmission of Transcriptional ...
PLOS ONE (2189197)
core   +1 more source

Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex [PDF]

, 2016
Inducible genes in yeast retain a "memory" of recent transcriptional activity during periods of short-term repression, allowing them to be reactivated faster when reinduced.

core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Clonal Transgenerational Effects of Parental Grazing Environment on Offspring Shade Avoidance

Agronomy
Grassland plants that endure livestock grazing exhibit a dwarf phenotype, which can be transmitted to clonal offspring. Yet to date, it remains poorly understood whether such transgenerational dwarf effects alter the plants’ response to shade.
Jingjing Yin, Weibo Ren, Ellen L. Fry, Ke Xu, Kairi Qu, Kairu Gao, Hailong Bao, Fenghui Guo   +7 more
doaj   +1 more source

Transcriptional memory in skeletal muscle. Don't forget (to) exercise

Journal of Cellular Physiology, 2020
Transcriptional memory describes an ancient and highly conserved form of cellular learning that enables cells to benefit from recent experience by retaining a mitotically inheritable but reversible memory of the initial transcriptional response when ...
T. Beiter, A. Nieß, Dirk Moser
semanticscholar   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source