Results 101 to 110 of about 5,670,610 (287)

A Yeast Catabolic Enzyme Controls Transcriptional Memory [PDF]

Current Biology, 2007
It has been postulated that chromatin modifications can persist through mitosis and meiosis, thereby securing memory of transcriptional states. Whether these chromatin marks can self-propagate in progeny independently of relevant trans-acting factors is an important question in phenomena related to epigenesis.
Zacharioudakis, Ioannis, Gligoris, Thomas, Tzamarias, Dimitris   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila

Nature Communications, 2021
The flexibility of memory updating may be determined in the initial memory consolidation process. Here, the authors show the proteomic changes of the transcriptional repressor complexes required for initial memory consolidation and influencing the ...
Mai Takakura, Reiko Nakagawa, Takeshi Ota, Yoko Kimura, Man Yung NG, Abdalla G. Alia, Hiroyuki Okuno, Yukinori Hirano   +7 more
doaj   +1 more source

The nuclear receptor PPARg controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory

Immunity, 2018
Graphical Abstract Figure. No caption available. SUMMARY Macrophages polarize into distinct phenotypes in response to complex environmental cues. We found that the nuclear receptor PPAR&ggr; drove robust phenotypic changes in macrophages upon repeated ...
B. Dániel, Gergely Nagy, Zsolt Czimmerer, Attila Horváth, D. Hammers, I. Cuaranta‐Monroy, S. Póliska, Petros Tzerpos, Zsuzsanna Kolostyák, Tristan T. Hays, Andreas Patsalos, R. Houtman, Sascha Sauer, Jean Francois-Deleuze, F. Rastinejad, B. Bálint, H. L. Sweeney, L. Nagy   +17 more
semanticscholar   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Transcriptional Regulation of Memory

, 2016
The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage.
Benedict C. Albensi, Jelena Djordjevic
openaire   +3 more sources

Dynamic physiological and transcriptomic changes reveal memory effects of salt stress in maize

BMC Genomics, 2023
Background Pre-exposing plants to abiotic stresses can induce stress memory, which is crucial for adapting to subsequent stress exposure. Although numerous genes involved in salt stress response have been identified, the understanding of memory responses
Zhiying Zhu, Yan Dai, Guangrun Yu, Xin Zhang, Qi Chen, Xiaobing Kou, Eid M. Mehareb, Ghulam Raza, Baohong Zhang, Baohua Wang, Kai Wang, Jinlei Han   +11 more
doaj   +1 more source

Memory CD8 T cell transcriptional plasticity [PDF]

F1000Prime Reports, 2015
Memory CD8 T cells generated after acute viral infections or live vaccines can persist for extended periods, in some instances for life, and play an important role in protective immunity. This long-lived immunity is achieved in part through cytokine-mediated homeostatic proliferation of memory T cells while maintaining the acquired capacity for rapid ...
Youngblood, Ben, Hale, J. Scott, Ahmed, Rafi   +2 more
openaire   +2 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Acute Heat Priming Dampens Gene Expression Response to Thermal Stress in a Widespread Acropora Coral

Ecology and Evolution
Physiological plasticity is fundamental for resisting environmental change. As climate change accelerates and environmental stressors become more frequent, understanding how habitat‐forming species shift their physiology to match their environment is ...
Declan J. A. Stick, W. Jason Kennington, Carolina Castro‐Sanguino, Shannon L. Duffy, James P. Gilmour, Luke Thomas   +5 more
doaj   +1 more source