Results 111 to 120 of about 5,670,610 (287)

Transcriptional regulation of memory B cell development [PDF]

Modern Rheumatology, 2001
Abstract Antigen-reactive B cells in the spleen of mice immunized with T cell-dependent antigens generate antibody-producing foci in periarteriolar lymphoid sheaths (PALS) or migrate into follicles to form germinal centers. Germinal center B cells clonally expand, have somatic hypermutation in IgV-region genes, are selected by apoptosis on the basis of
T, Tokuhisa, M, Hatano, S, Okada, T, Fukuda, I, Kunimasa   +4 more
openaire   +2 more sources

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man

Cell Reports, 2015
Following exposure to vaccines, antigen-specific CD8+ T cell responses develop as long-term memory pools. Vaccine strategies based on adenoviral vectors, e.g., those developed for HCV, are able to induce and sustain substantial CD8+ T cell populations ...
Beatrice Bolinger, Stuart Sims, Leo Swadling, Geraldine O’Hara, Catherine de Lara, Dilair Baban, Natasha Saghal, Lian Ni Lee, Emanuele Marchi, Mark Davis, Evan Newell, Stefania Capone, Antonella Folgori, Ellie Barnes, Paul Klenerman   +14 more
doaj   +1 more source

Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp11

, 2022
A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal aging as animals encounter a multitude of
Svermova, Tatiana, Alic, Nazif, Goncalves, Alex, Southall, Tony, Li, Mengjia, Dobson, Adam, Martinez Corrales, Guillermo, Voicu, Diana   +7 more
core  

The role of chromatin and cofactors in the transcriptional memory effect exerted in Saccharomyces cerevisiae [PDF]

, 2012
Abf1 and Rap1 are functionally similar general regulatory factors (GRFs) found in Saccharomyces cerevisiae . Abf1, in its role as a transcriptional activator, exerts a memory effect on some genes under its control.
Paul, Emily Leigh
core   +1 more source

Chromatin Mediation of a Transcriptional Memory Effect in Yeast [PDF]

G3 Genes|Genomes|Genetics, 2015
Abstract Previous studies have described a transcriptional “memory effect,” whereby transcript levels of many Abf1-regulated genes in the budding yeast Saccharomyces cerevisiae are undiminished even after Abf1 has dissociated from its regulatory sites. Here we provide additional support for this effect and investigate its molecular basis.
Paul, Emily, Tirosh, Itay, Lai, William, Buck, Michael J., Palumbo, Michael J., Morse, Randall H.   +5 more
openaire   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures--Cell Surface FCS

, 2021
FCS files corresponding to the cell surface experiment described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures"Funding provided in part by the Aligning Science Across Parkinson's ASAP ...
Yaqian Xu, João Rodrigues Lima-Junior;, Dhanwani, Rekha, Sulzer, David, John Pham, Sette, Alessandro, Rekha Dhanwani, David Sulzer, April Frazier, Xu, Yaqian, Alcalay, Roy N, Amara, Amy, Sethi, Ashu, Gregory Williams, Williams, Gregory, Roy N. Alcalay, Frazier, April, Peters, Bjoern, Alessandro Sette, Litvan, Irene, Arlehamn, Cecilia S, Amy W. Amara, Cecilia S. Lindestam Arlehamn, Bjoern Peters, Lima-Junior;, João Rodrigues, David G. Standaert, Goldman, Jennifer G, Ashu Sethi, Jennifer G. Goldman, Irene Litvan, Pham, John, Standaert, David G   +31 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source