Results 131 to 140 of about 5,670,610 (287)

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

A memory transcriptome time course reveals essential long-term memory transcription factors

Nature Communications
Long-term memory (LTM) requires transcription and translation of new proteins, yet the transcriptional control of memory remains poorly understood. Here, we performed a transcriptome time-course during LTM formation in Drosophila melanogaster exposed to ...
Spencer G. Jones, Beatriz Gil-Martí, Eva Sacristán-Horcajada, Abigail C. Edison, Emily F. Butler, Neda Miandashti, Camilla Roselli, Enrique Turiégano, Tamara Boto, Jamie M. Kramer, Francisco A. Martin   +10 more
doaj   +1 more source

Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

Cell Reports, 2019
Summary: Dopamine (DA) activates mitogen-activated protein kinase (MAPK) via protein kinase A (PKA)/Rap1 in medium spiny neurons (MSNs) expressing the dopamine D1 receptor (D1R) in the nucleus accumbens (NAc), thereby regulating reward-related behavior ...
Yasuhiro Funahashi, Anthony Ariza, Ryosuke Emi, Yifan Xu, Wei Shan, Ko Suzuki, Sachi Kozawa, Rijwan Uddin Ahammad, Mengya Wu, Tetsuya Takano, Yoshimitsu Yura, Keisuke Kuroda, Taku Nagai, Mutsuki Amano, Kiyofumi Yamada, Kozo Kaibuchi   +15 more
doaj   +1 more source

Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells

Immunity, 2019
Stable changes in chromatin states and gene expression in cells of the immune system form the basis for memory of infections and other challenges. Here, we used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore ...
J. van der Veeken, Y. Zhong, Roshan Sharma, L. Mažutis, Phuong H. Dao, D. Pe'er, C. Leslie, A. Rudensky   +7 more
semanticscholar   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. [PDF]

, 2012
After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout ...
J Adam Best, Dustin, Michael L., Michael L Dustin, Jamie Knell, Knell, Jamie, Dustin, Michael L, Ananda W Goldrath, Best, J. Adam, Blair, David, Doedens, Andrew, Best, J Adam, David A Blair, Andrew Doedens, Goldrath, Ananda, Yang, Edward, Goldrath, Ananda W., Dustin, Michael, Mayya, Viveka, Regev, Aviv, Blair, David A., Edward Yang, Blair, David A, Viveka Mayya, Goldrath, Ananda W   +23 more
core   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

A changing paradigm of transcriptional memory propagation through mitosis

Nature reviews. Molecular cell biology, 2018
The highly reproducible inheritance of chromosomes during mitosis in mammalian cells involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range intrachromosomal interactions, loss of enhancer–promoter proximity, displacement ...
Katherine C. Palozola, J. Lerner, K. Zaret   +2 more
semanticscholar   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source