Results 121 to 130 of about 5,670,610 (287)
Cell Reports, 2016 One critical event in reprogramming to pluripotency is erasure of the somatic transcriptional program of starting cells. Here, we present the proof of principle of a strategy for reprogramming to pluripotency facilitated by small molecules that interfere
Zhicheng Shao +6 more
doaj +1 more source
, 2021 FCS files corresponding to the gene validation experiment described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures" Funding provided in part by the Aligning Science Across Parkinson’s ASAP ...
Yaqian Xu +31 more
core +1 more source
Nuclear Memory: Gene Transcription and Behavior
, 1997 Publisher Summary The most widely studied immediate early genes belong to the Fos family. This family includes c-fos, fosB, fra1, and fra2 . When activated, these genes transcribe their protein products, designated C-FOSF, FosB, FRA1, and FRA2, respectively.
N, Hiroi, E J, Nestler
openaire +2 more sources
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
Interferon stimulation creates chromatin marks and establishes transcriptional memory
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Epigenetic memory for experience-based gene expression has not been well studied in higher organisms. Here we demonstrate that cells previously exposed to interferons exhibit a memory response and mount faster and higher transcription upon ...
Rui Kamada +12 more
semanticscholar +1 more source
Transcriptional Correlates of Savings Memory for Long-Term Sensitization in Aplysia Californica
, 2017 Savings memory persists beyond the decay of recall. What transcriptional changes persist as well?
Robert Calin-Jageman
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
bioRxiv, 2019 Heat shock triggers an instant reprogramming of gene and enhancer transcription, but whether cells encode a memory to stress, at the level of nascent transcription, has remained unknown.
Anniina Vihervaara +5 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source