Results 71 to 80 of about 5,670,610 (287)

Summary of transcriptional memory experiments.

, 2014
*SEM = standard error of the mean (N = number of cells).Summary of transcriptional memory experiments.
Matthew W. Lux (258412), Jean Peccoud (142023), Neil R. Adames (388181), David A. Ball (199606)   +3 more
core   +1 more source

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

Cell Reports, 2015
Nucleotide pool imbalance has been proposed to drive genetic instability in cancer. Here, we show that slowing replication forks by depleting nucleotide pools with hydroxyurea (HU) can also give rise to both transient and permanent epigenetic instability
Charikleia Papadopoulou, Guillaume Guilbaud, Davide Schiavone, Julian E. Sale   +3 more
doaj   +1 more source

Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine

Vaccines, 2021
Long-lived memory cell formation and maintenance are usually regulated by cytokines and transcriptional factors. Adjuvant effects of IL-7 have been studied in the vaccines of influenza and other pathogens.
Jiangyuan Han, Yanlin Ma, Lan Ma, Daquan Tan, Hongxia Niu, Chunxiang Bai, Youjun Mi, Tao Xie, Wei Lv, Juan Wang, Bingdong Zhu   +10 more
doaj   +1 more source

H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. [PDF]

PLoS Biology, 2007
Many genes are recruited to the nuclear periphery upon transcriptional activation. The mechanism and functional significance of this recruitment is unclear.
Donna Garvey Brickner, Ivelisse Cajigas, Yvonne Fondufe-Mittendorf, Sara Ahmed, Pei-Chih Lee, Jonathan Widom, Jason H Brickner   +6 more
doaj   +1 more source

Transcriptional memory emerges from cooperative histone modifications [PDF]

, 2011
Background Transcriptional regulation in cells makes use of diverse mechanisms to ensure that functional states can be maintained and adapted to variable environments; among them are chromatin-related mechanisms.
Thimo Rohlf, Hans Binder, Lydia Steiner, Sonja Prohaska, Joerg Galle   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Perinatal nicotine exposure disrupts hematopoietic stem cell development and elevates influenza severity in adulthood

Stem Cell Reports
Summary: Developmental exposures profoundly shape lifelong health by altering disease resilience later in life. One potential cause of increased disease susceptibility is an altered immune system, originating in epigenetically maladaptive hematopoietic ...
M.G.E. Rommel, T. Cool, A. Rodriguez y Baena, S. Saini, P. Medina, C. Mattingly, E. Bachinsky, S. Chattopadhyaya, B.A. Manso, S. Rajendiran, A.K. Worthington, D.M. Poscablo, A. Deguzman, P.Q. Wimer, I.M. Voelker, T. Berger-Cahn, L. Langroudi, A.F. Svendsen, A. Shariati, S. Carpenter, D.F. Boyd, E.C. Forsberg   +21 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Single-cell transcriptome analysis of CD8+ T-cell memory inflation [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”.
Andrew J. Highton, Madeleine E. Zinser, Lian Ni Lee, Claire L. Hutchings, Catherine De Lara, Chansavath Phetsouphanh, Chris B. Willberg, Claire L. Gordon, Paul Klenerman, Emanuele Marchi   +9 more
doaj   +1 more source