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Reconciling Epigenetic Memory and Transcriptional Responsiveness [PDF]
Cell Systems, 2017 The molecular basis of cellular memory is important but poorly understood. Using estimates of histone dynamics, Martin Howard and colleagues construct a mathematical model that helps to explain both the stability and flexibility of Polycomb-mediated gene regulation in cellular memory.
Fisher, AG +2 more
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Transcriptional memory at the nuclear periphery [PDF]
Current Opinion in Cell Biology, 2009 A number of inducible yeast genes are targeted to the nuclear periphery upon transcriptional activation. However, when repressed again, the INO1 and GAL1 genes remain at the nuclear periphery for multiple generations. Retention at the nuclear periphery represents a novel type of transcriptional memory; the peripherally localized, recently repressed ...
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Role of chromatin states in transcriptional memory [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009 Establishment of cellular memory and its faithful propagation is critical for successful development of multicellular organisms. As pluripotent cells differentiate, choices in cell fate are inherited and maintained by their progeny throughout the lifetime of the organism.
Sharmistha, Kundu, Craig L, Peterson
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INO1 transcriptional memory leads to DNA zip code-dependent interchromosomal clustering
Microbial Cell, 2015 Many genes localize at the nuclear periphery through physical interaction with the nuclear pore complex (NPC). We have found that the yeast INO1 gene is targeted to the NPC both upon activation and for several generations after repression, a phenomenon ...
Donna Garvey Brickner +2 more
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Vaccines, 2021 Long-lived memory cell formation and maintenance are usually regulated by cytokines and transcriptional factors. Adjuvant effects of IL-7 have been studied in the vaccines of influenza and other pathogens.
Jiangyuan Han +10 more
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Maintaining a memory by transcriptional autoregulation [PDF]
Current Biology, 2011 One of the key features of cellular differentiation programs is stability. Although differentiation is reversible in principle, many components of the gene batteries induced upon terminal differentiation are maintained throughout a cell's life. For example, muscle cells continuously express the myosin gene, and GABAergic neurons continuously express ...
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Transcriptional Memory: Staying in the Loop [PDF]
Current Biology, 2010 Actively transcribed genes are organized into loops in which the 5' and 3' ends of the gene physically associate. Two new papers show that gene looping can persist after genes are repressed, promoting rapid reactivation of transcription, a phenomenon known as transcriptional memory.
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Transcriptional co-repressors and memory storage [PDF]
Neuropharmacology, 2014 Epigenetic modifications are a central mechanism for regulating chromatin structure and gene expression in the brain. A wide array of histone- and DNA-modifying enzymes have been identified as critical regulators of neuronal function, memory formation, and as causative agents in neurodevelopmental and neuropsychiatric disorders.
Hannah Schoch, Ted Abel
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Transcriptional regulation of memory B cell differentiation [PDF]
Nature Reviews Immunology, 2020 Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been ...
Brian J. Laidlaw, Jason G. Cyster
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Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression
Cell Reports, 2015 Nucleotide pool imbalance has been proposed to drive genetic instability in cancer. Here, we show that slowing replication forks by depleting nucleotide pools with hydroxyurea (HU) can also give rise to both transient and permanent epigenetic instability
Charikleia Papadopoulou +3 more
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