Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes. [PDF]
Life Sci Alliance, 2021 Glucocorticoids are stress hormones that elicit various cellular responses. These responses are typically reversible; however, in some instances, a previous exposure is “remembered” and influences the response to a subsequent hormone encounter ...
Bothe M, Buschow R, Meijsing SH.
europepmc +2 more sources
The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants. [PDF]
Free Radic Biol Med, 2021 People are exposed to wide range of redox-active environmental pollutants. Air pollution, heavy metals, pesticides, and endocrine disrupting chemicals can disrupt cellular redox status.
Weinhouse C.
europepmc +2 more sources
Remembering foods and foes: emerging principles of transcriptional memory. [PDF]
Cell Death Differ, 2023 Tehrani SSH +3 more
europepmc +2 more sources
Biotic Stress-Induced Priming and De-Priming of Transcriptional Memory in Arabidopsis and Apple
Epigenomes, 2019 Under natural growth conditions, plants experience various and repetitive biotic and abiotic stresses. Salicylic acid (SA) is a key phytohormone involved in the response to biotic challenges.
Kay Gully +5 more
doaj +2 more sources
Memory and relatedness of transcriptional activity in mammalian cell lineages [PDF]
Nature Communications, 2019 Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of ...
Nicholas E. Phillips +4 more
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Safeguarding Transcriptional Memory: A Mitotic Bookmarking Role for Chromatin Remodelers [PDF]
Signal Transduction and Targeted Therapy, 2023 Huu Phuc Nguyen +2 more
exaly +2 more sources
Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
eLife, 2016 In yeast and humans, previous experiences can lead to epigenetic transcriptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and promoter recruitment of poised RNA polymerase II preinitiation complex (RNAPII ...
Agustina D'Urso +8 more
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Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
Cell Reports, 2018 Summary: Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as ...
Tomoyuki Miyashita +3 more
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Editorial: Transcriptional Regulation of Memory [PDF]
Frontiers in Molecular Neuroscience, 2016 Memory is the capacity for retaining and reviving information, facts, events, impressions, etc., and of recalling or recognizing previous experiences (Kandel et al., 2013). The formation of human memories involves a series of complicated biochemical processes, many of which are not fully understood. Short-term, intermediate-term, and long-term memories
Benedict C Albensi, Jelena eDjordjevic
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A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals
Nature Genetics, 2021 International audienceEpigenetic inheritance of gene expression states enables a single genome to maintain distinct cellular identities. How histone modifications contribute to this process remains unclear. Using global chromatin perturbations and local,
D. Holoch +9 more
semanticscholar +2 more sources