Dynamic force-induced nucleoporin stretch mechanomemory prolongs nuclear pore complex dilation and importin transport [PDF]
APL BioengineeringHow the nuclear pore complex (NPC) is dynamically regulated by mechanical stimuli is poorly understood. Herein, using FRET (fluorescence resonance energy transfer) spectroscopy and MINFLUX (MINimal fluorescence photon FLUXes) nanoscopy, we demonstrate ...
Fazlur Rashid +2 more
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Cytoplasmic Nucleoporin Assemblage: The Cellular Artwork in Physiology and Disease
NucleusNucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures ...
Izabela Sumara, Junyan Lin
exaly +3 more sources
Mis-localized nucleoporin POM121C potently inhibits nuclear entry of HIV-1 but leads to the outgrowth of viral escape mutants [PDF]
Journal of VirologyNuclear entry of HIV-1 involves specific interactions between the viral capsid and components of the nuclear pore complex. FG-repeat sequences present in many nucleoporins play important roles in HIV-1 nuclear entry.
Hideki Saito +10 more
doaj +2 more sources
Nucleoporin Nup96 promotes plant photomorphogenesis by facilitating phyB photobody formation and HOS1-mediated PIF5 degradation in Arabidopsis [PDF]
Plant CommunicationsThe initiation of light signaling involves the formation of phyB nuclear photobodies (PBs). The nuclear pore complex (NPC) is the sole gate for macromolecule transport between the cytoplasm and nucleus; however, its role in phyB PB formation and light ...
Yacong Wang +4 more
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Correct dosage of X chromosome transcription is controlled by a nuclear pore component
Cell Reports, 2021 Summary: Dosage compensation in Drosophila melanogaster involves a 2-fold transcriptional upregulation of the male X chromosome, which relies on the X-chromosome-binding males-specific lethal (MSL) complex.
Jennifer R. Aleman +7 more
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Cells, 2022 Steroid-resistant nephrotic syndrome (SRNS) frequently leads to end-stage renal disease, ultimately requiring kidney replacement therapies. SRNS is often caused by hereditary monogenic mutations, specifically affecting specialized epithelial cells ...
Manuel Rogg +6 more
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New Activities of the Nuclear Pore Complexes
Cells, 2021 Nuclear pore complexes (NPCs) at the surface of nuclear membranes play a critical role in regulating the transport of both small molecules and macromolecules between the cell nucleus and cytoplasm via their multilayered spiderweb-like central channel ...
Richard W. Wong
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Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae
Biology Open, 2021 Pom152 is a transmembrane protein within the nuclear pore complex (NPC) of fungi that is important for NPC assembly and structure. Pom152 is comprised of a short amino-terminal region that remains on the cytosolic side of the nuclear envelope (NE) and ...
Jacqueline T. Brown +3 more
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Nuclear pore complex and stem cell homeostasis
生物医学转化, 2021 As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins.
Li Lanzhu +4 more
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Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression
Cells, 2021 The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation.
Jana Uhlířová +5 more
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