Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules [PDF]
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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The bioenergetics of nucleocytoplasmic transport. [PDF]
J Cell BiolHow nucleocytoplasmic transport (NCT) rates change due to cellular physiology-mediated fluctuations in GTP availability remains unclear. In this issue, Scott et al. (https://doi.org/10.1083/jcb.202308152) demonstrate that cell migration, spreading, and nucleocytoskeletal coupling impact GTP levels, thereby regulating NCT, RNA export, and protein ...
Luxton GWG.
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Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD [PDF]
Brain Sciences, 2021 Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with available treatments only marginally slowing progression or improving survival.
Melina Ramic +6 more
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C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm [PDF]
Scientific Reports, 2022 A repeat expansion in C9orf72 is the major cause of both frontotemporal dementia and amyotrophic lateral sclerosis, accounting for approximately 1 in 12 cases of either disease. The expansion is translated to produce five dipeptide repeat proteins (DPRs)
Sarah Ryan +3 more
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Impaired nucleocytoplasmic transport in SOD1-mediated ALS [PDF]
Molecular NeurodegenerationBackground Impaired nucleocytoplasmic transport (NCT) has emerged as a shared pathogenic mechanism in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in the gene encoding superoxide dismutase 1 (SOD1)
Shirel Argueti-Ostrovsky +22 more
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Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS [PDF]
Frontiers in Cellular Neuroscience, 2023 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that are part of a common disease spectrum due to clinical, genetic, and pathological overlap. A prominent genetic factor contributing to
Philip McGoldrick +2 more
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Functional insights of nucleocytoplasmic transport in plants
Frontiers in Plant Science, 2014 Plant nucleocytoplasmic transport beyond the nuclear envelope is important not only for basic cellular functions but also for growth, development, hormonal signalling, and responses to environmental stimuli.
Kentaro eTamura, Ikuko eHara-Nishimura
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Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state [PDF]
Nature Communications, 2023 Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids.
Lixin Wang +3 more
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Understanding the role of mechanics in nucleocytoplasmic transport [PDF]
APL Bioengineering, 2022 Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs ...
Ion Andreu +3 more
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Karyopherin-mediated nucleocytoplasmic transport. [PDF]
Nat Rev Mol Cell Biol, 2022 Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-β (or Kap) family of nuclear transport receptors.
Wing CE, Fung HYJ, Chook YM.
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