Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules [PDF]
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm [PDF]
Scientific Reports, 2022 A repeat expansion in C9orf72 is the major cause of both frontotemporal dementia and amyotrophic lateral sclerosis, accounting for approximately 1 in 12 cases of either disease. The expansion is translated to produce five dipeptide repeat proteins (DPRs)
Sarah Ryan +3 more
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Impaired nucleocytoplasmic transport in SOD1-mediated ALS [PDF]
Molecular NeurodegenerationBackground Impaired nucleocytoplasmic transport (NCT) has emerged as a shared pathogenic mechanism in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in the gene encoding superoxide dismutase 1 (SOD1)
Shirel Argueti-Ostrovsky +22 more
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Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS [PDF]
Frontiers in Cellular Neuroscience, 2023 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that are part of a common disease spectrum due to clinical, genetic, and pathological overlap. A prominent genetic factor contributing to
Philip McGoldrick +2 more
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Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state [PDF]
Nature Communications, 2023 Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids.
Lixin Wang +3 more
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TMEM63B regulates nucleocytoplasmic transport and placental development [PDF]
Nature CommunicationsThe placental development requires coordinated trophoblast proliferation and differentiation, processes tightly coupled to cell cycle control. Here, we identify TMEM63B, an osmo/mechano-sensitive ion channel, as a key regulator of trophoblast cell cycle ...
Mengya Cai +7 more
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Understanding the role of mechanics in nucleocytoplasmic transport [PDF]
APL Bioengineering, 2022 Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs ...
Ion Andreu +3 more
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Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport [PDF]
Advanced ScienceMechanical forces, including flow shear stress, govern fundamental cellular processes by modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein (YAP). However, the underlying mechanical mechanism remains elusive.
Tianxiang Ma +22 more
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Brain Sciences, 2021 Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with available treatments only marginally slowing progression or improving survival.
Melina Ramic +6 more
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Cells, 2021 The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah +2 more
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