Results 1 to 10 of about 15,740 (146)
Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single adhesive cells, mechanotransduction involves the transmission of force from the extracellular matrix to the cell nucleus,
Granero Moya, Ignasi +12 more
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Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease.
, 2015 Nucleocytoplasmic transport is an essential cellular activity and occurs via nuclear pore complexes (NPCs) that reside in the double membrane of the nuclear envelope.
Fahrenkrog, Birthe +5 more
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Regulated nucleocytoplasmic transport in spermatogenesis: A driver of cellular differentiation?
, 2005 This review explores the hypothesis that regulation of nucleocytoplasmic shuttling is a means of driving differentiation, using spermatogenesis as a model.
David A. Jans +7 more
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, 2009 The hallmark of eukaryotic evolution was the development of the nucleus in cells. This compartmentalization requires the nucleocytoplasmic transport of thousands of molecules. The gate into and out of the nucleus is the nuclear pore complex (NPC). One of
Moeller, Holger von, Moeller, H.
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The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
, 2015 The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Zhang, Ke +54 more
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Assessing Nucleocytoplasmic transport in Spinocerebellar Ataxia type 7
, 2021 SCA7 is an autosomal dominant CAG/polyglutamine trinucleotide repeat expansion disease that accounts for ~4% of all spinocerebellar ataxias in the USA.
Macopson Jones, Joshua
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, 2022 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. The pathogenic mechanisms driving ALS are unclear, and no effective treatment is available.
Kumar, Meenakshi Sundaram
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, 2005 The thesis entitled „Investigations on the significance of nucleo-cytoplasmic transport for the biological function of cellular proteins" aimed to unreveal molecular mechanisms in order to improve our understanding of the impact of nucleo-cytoplasmic ...
Knauer, Shirley
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Organization and regulation of nucleocytoplasmic transport
, 2021 Separation of DNA replication and transcription, which occur in the nucleus, from protein synthesis, which occurs in the cytoplasm, allows a more precise regulation of these processes.
Chumakov S.P.
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Characterization of the cellular functions of the nucleoporins Nup153 and Nup88 [PDF]
, 2010 Characterization of the Cellular Functions of the Nucleoporins Nup153 and Nup88 PhD Thesis, Yvonne Christine Lussi, 2010, University of Basel Nuclear pore complexes (NPCs) and nuclear lamins are major constituents of the nuclear envelope (NE) in ...
Lussi, Yvonne Christine
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