Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules [PDF]
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD [PDF]
Brain Sciences, 2021 Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with available treatments only marginally slowing progression or improving survival.
Melina Ramic +6 more
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Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS [PDF]
Frontiers in Cellular Neuroscience, 2023 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that are part of a common disease spectrum due to clinical, genetic, and pathological overlap. A prominent genetic factor contributing to
Philip McGoldrick +2 more
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Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state [PDF]
Nature Communications, 2023 Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids.
Lixin Wang +3 more
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C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm [PDF]
Scientific Reports, 2022 A repeat expansion in C9orf72 is the major cause of both frontotemporal dementia and amyotrophic lateral sclerosis, accounting for approximately 1 in 12 cases of either disease. The expansion is translated to produce five dipeptide repeat proteins (DPRs)
Sarah Ryan +3 more
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Impaired nucleocytoplasmic transport in SOD1-mediated ALS [PDF]
Molecular NeurodegenerationBackground Impaired nucleocytoplasmic transport (NCT) has emerged as a shared pathogenic mechanism in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in the gene encoding superoxide dismutase 1 (SOD1)
Shirel Argueti-Ostrovsky +22 more
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Understanding the role of mechanics in nucleocytoplasmic transport [PDF]
APL Bioengineering, 2022 Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs ...
Ion Andreu +3 more
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Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration [PDF]
Bio-Protocol, 2020 Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste +4 more
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Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex. [PDF]
PLoS Biology, 2016 The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have ...
Samson O Obado +7 more
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Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer [PDF]
Heliyon, 2021 Transport of functional molecules across the nuclear membrane of a eukaryotic cell is regulated by a dedicated set of transporter proteins that carry molecules into the nucleus or out of the nucleus to the cytoplasm for homeostasis of the cell.
Rashid Mehmood +3 more
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