Results 1 to 10 of about 152,718 (137)

Protein Biomarkers in Risk and Prognosis of Amyotrophic Lateral Sclerosis. [PDF]

Eur J Neurol
ABSTRACT Background Plasma and cerebrospinal fluid (CSF) protein biomarkers in amyotrophic lateral sclerosis (ALS) may provide insight into disease mechanisms and yield clinically useful biomarkers. Methods Overall, 363 proteins in plasma and CSF from 198 patients with ALS and 125 matched controls were profiled using Olink assays.
Pan L, Hou C, Seitz C, Ingre C, Hedman ÅK, Laffita J, Vu TN, Pawitan Y, Ullgren A, Yazdani S, Andersson J, Joyce EE, Chourpiliadis C, Lovik A, Chen Y, Lewandowski SA, Fernandez-Capetillo O, Barz M, Samuelsson K, Press R, Piehl F, Graff C, Mälarstig A, Fang F.   +23 more
europepmc   +2 more sources

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Zanovello M, Serani F, Bebeti A, Paredi F, Quadrio G, Fortuna A, Minicuci GM, Pegoraro E, Cagnin A, Cecchin D, Sorarù G.   +10 more
europepmc   +2 more sources

A machine-learning based objective measure for ALS disease severity

npj Digital Medicine, 2022
Amyotrophic Lateral Sclerosis (ALS) disease severity is usually measured using the subjective, questionnaire-based revised ALS Functional Rating Scale (ALSFRS-R).
Fernando G. Vieira, Subhashini Venugopalan, Alan S. Premasiri, Maeve McNally, Aren Jansen, Kevin McCloskey, Michael P. Brenner, Steven Perrin   +7 more
doaj   +1 more source

Trace and major elements in food supplements of different origin: Implications for daily intake levels and health risks

Toxicology Reports, 2021
As the use of food supplements increases, voices are being raised questioning the safety of these products. As a contribution to understanding the trace and major elemental composition of food supplements and their potential health risks, this study ...
A. Augustsson, A. Qvarforth, E. Engström, C. Paulukat, I. Rodushkin   +4 more
doaj   +1 more source

Effects of intracellular calcium accumulation on proteins encoded by the major genes underlying amyotrophic lateral sclerosis

Scientific Reports, 2022
The aetiology of Amyotrophic Lateral Sclerosis (ALS) is still poorly understood. The discovery of genetic forms of ALS pointed out the mechanisms underlying this pathology, but also showed how complex these mechanisms are.
Giovanni De Marco, Annarosa Lomartire, Umberto Manera, Antonio Canosa, Maurizio Grassano, Federico Casale, Giuseppe Fuda, Paolina Salamone, Maria Teresa Rinaudo, Sebastiano Colombatto, Cristina Moglia, Adriano Chiò, Andrea Calvo   +12 more
doaj   +1 more source

Förderung digitalisierungsbezogener Kompetenzen in der sprachlichen Bildung bei Lehramtsstudierenden

Herausforderung Lehrer*innenbildung, 2023
Im Kontext der Digitalisierung obliegt es Lehrkräften als fächerübergreifende Querschnittsaufgabe, digitale Tools auch zur Unterstützung des sprachlichen Lernens von Schüler*innen einzusetzen.
Cedric Lawida, Janna Gutenberg, Christoph Gantefort   +2 more
doaj   +1 more source

The impact of respite care from the perspectives and experiences of people with amyotrophic lateral sclerosis and their care partners: a qualitative study

BMC Palliative Care, 2022
Background Respite care provides caregiving support to people with amyotrophic lateral sclerosis (ALS) and their care partners by providing the care partner with temporary relief from their caregiving duties.
Julia M. Wu, Mallorie T. Tam, Kirsten Buch, Fouziah Khairati, Laurissa Wilson, Elizabeth Bannerman, Alexandra Guerrero, Andrew Eisen, Wendy Toyer, Travis Stevenson, Julie M. Robillard   +10 more
doaj   +1 more source

A comprehensive Review of Amyotrophic Lateral Sclerosis Including: Prevalence, Pathogenesis, Biomarkers Diagnosis, and Current Treatment Options [PDF]

Reviews in Clinical Medicine, 2021
Amyotrophic lateral sclerosis (ALS) also known as motor neuron disease is a destroying neurodegenerative disease that mainly affects the upper and lower motor neurons.
Najmeh Malekzadeh
doaj   +1 more source

Extracellular vesicle-based therapy for amyotrophic lateral sclerosis

Brain Circulation, 2021
Amyotrophic lateral sclerosis (ALS) stands as a neurodegenerative disorder characterized by the rapid progression of motor neuron loss in the brain and spinal cord. Unfortunately, treatment options for ALS are limited, and therefore, novel therapies that
Nadia Sadanandan, Jea-Young Lee, Svitlana Garbuzova-Davis   +2 more
doaj   +1 more source

Resistance of Monochoria vaginalis to Bensulfuron-methyl in Central Java and East Java Indonesia [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
Monochoria vaginalis is one of the dominant weeds in rice crop fields of Central Java and East Java Indonesia and it failed to be controlled by herbicides with the active ingredient bensulfuron-methyl. The research was carried out using split plotdesign
Denny Kurniadie, Ryan Widianto, Dedi Widayat, Uum Umiyati, Ceppy Nasahi   +4 more
doaj   +1 more source