Results 11 to 20 of about 2,739,321 (263)

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.

New England Journal of Medicine, 2022
BACKGROUND The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in SOD1 (SOD1 ...
Timothy A. Miller, M. Cudkowicz, A. Genge, P. Shaw, G. Sobue, R. Bucelli, A. Chiò, P. van Damme, A. Ludolph, J. Glass, Jinsy A. Andrews, Suma Babu, M. Benatar, C. Mcdermott, T. Cochrane, Sowmya Chary, Sheena Chew, Handong Zhu, Fan Wu, I. Nestorov, D. Graham, P. Sun, M. McNeill, L. Fanning, T. Ferguson, S. Fradette   +25 more
semanticscholar   +1 more source

Recent advances in the diagnosis and prognosis of ALS

Lancet Neurology, 2022
Diagnosing ALS can be challenging due to heterogeneity in clinical presentation and overlap with other neurological and neuropsychological conditions. Earlier diagnosis can improve ALS patient outcomes as timely interventions slow disease progression. An
Stephen A. Goutman, O. Hardiman, A. Al-Chalabi, A. Chiò, M. G. Savelieff, M. Kiernan, E. Feldman   +6 more
semanticscholar   +1 more source

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

Nature, 2021
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1.
X. Ma, M. Prudencio, Y. Koike, S. Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, T. Akiyama, H. B. Schmidt, Beryl B. Cummings, David W. Wyatt, K. Kurylo, Georgiana Miller, S. Mekhoubad, Nathan A. Sallee, G. Mekonnen, Laura R. Ganser, Jack D. Rubien, Karen R. Jansen-West, C. Cook, Sarah R Pickles, Björn E. Oskarsson, N. Graff-Radford, B. Boeve, D. Knopman, R. Petersen, D. Dickson, J. Shorter, Sua Myong, Eric M. Green, W. Seeley, L. Petrucelli, A. Gitler   +34 more
semanticscholar   +1 more source

Extracellular vesicle-based therapy for amyotrophic lateral sclerosis

Brain Circulation, 2021
Amyotrophic lateral sclerosis (ALS) stands as a neurodegenerative disorder characterized by the rapid progression of motor neuron loss in the brain and spinal cord. Unfortunately, treatment options for ALS are limited, and therefore, novel therapies that
Nadia Sadanandan, Jea-Young Lee, Svitlana Garbuzova-Davis   +2 more
doaj   +1 more source

Resistance of Monochoria vaginalis to Bensulfuron-methyl in Central Java and East Java Indonesia [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
Monochoria vaginalis is one of the dominant weeds in rice crop fields of Central Java and East Java Indonesia and it failed to be controlled by herbicides with the active ingredient bensulfuron-methyl. The research was carried out using split plotdesign
Denny Kurniadie, Ryan Widianto, Dedi Widayat, Uum Umiyati, Ceppy Nasahi   +4 more
doaj   +1 more source

Emerging insights into the complex genetics and pathophysiology of ALS

Lancet Neurology, 2022
Summary ALS is a fatal neurodegenerative disease. The discovery of ALS genes, commencing with SOD1, started relatively gradually. Recent advances in genetic technology have led to the rapid identification of multiple new ALS genes, and a new ...
Stephen A. Goutman, O. Hardiman, A. Al-Chalabi, A. Chiò, M. G. Savelieff, M. Kiernan, E. Feldman   +6 more
semanticscholar   +1 more source

Al-Madāris Al-Qurāniyyaħ Fī Al-Qarn Al-Ṡānī Al-Hijrī

Zad Al-Mufassirin, 2021
The purpose of this study is to analyze the historical record and participation and contribution of qur'aniyah madrassas that exist in the second year of hijri. This research uses analytical descriptive methods by referring to and analyzing data from key sources directly related to the theme.
Nabil Ahmed Tarmom, Adha Saputra
openaire   +3 more sources

Genetics of familial amyotrophic lateral sclerosis

Бюллетень сибирской медицины, 2021
To analyze results of the studies covering modern scientific views on the genetics of familial amyotrophic lateral sclerosis (FALS).We searched for full-text publications containing the key words “amyotrophic lateral sclerosis”, “FALS”, and “genetics” in
A. V. Savinova, N. A. Shnayder, R. F. Nasyrova   +2 more
doaj   +1 more source

The Efficacy and Safety of Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis: A Pilot Study [PDF]

Advanced Pharmaceutical Bulletin, 2023
Purpose: Amyotrophic lateral sclerosis (ALS) is an uncommon and aggressive neurodegenerative disorder that influences the lower and upper motor neurons.
Gholamreza Shamsaei, Fatemeh Houshmand, Ahmad Ahmadzadeh Deylami, Armita Valizadeh, Shahram Rafie, Maryam Moradi   +5 more
doaj   +1 more source

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Cell, 2020
Summary Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB) and type I interferon (IFN ...
Chien-Hsiung Yu, Sophia Davidson, C. Harapas, J. B. Hilton, Michael J. Mlodzianoski, P. Laohamonthonkul, Cynthia Louis, R. R. J. Low, Jonas Moecking, D. De Nardo, Katherine R. Balka, D. Calleja, F. Moghaddas, Erya Ni, C. Mclean, A. Samson, S. Tyebji, C. Tonkin, C. Bye, B. J. Turner, Geneviève Pépin, M. Gantier, K. Rogers, K. McArthur, P. Crouch, S. Masters   +25 more
semanticscholar   +1 more source