Results 1 to 10 of about 12,167,877 (179)

The Health Benefits of Exercise: Molecular and Cellular Mechanisms. [PDF]

MedComm (2020)
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Ying P, Wang H, Lu X, Zhang W, Lin Z, Wang K, Li S, Chen L, Jiang M, Hamad S, Wang Y, Wu J, Ling S.   +12 more
europepmc   +2 more sources

Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects. [PDF]

Adv Sci (Weinh)
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Xu F, Wang K, Lu K, Hou T, Chen Y, Wang X, Jin H.   +6 more
europepmc   +2 more sources

Novel isothermal nucleic acid amplification method for detecting malaria parasites. [PDF]

Appl Microbiol Biotechnol
de Queiroz LT, Baptista BO, de Abreu-Fernandes R, Pereira CSF, Lemos JAS, de Souza HADS, Martorano RM, Riccio EKP, Totino PRR, Oliveira-Ferreira J, Lima-Junior JDC, Daniel-Ribeiro CT, Pratt-Riccio LR.   +12 more
europepmc   +1 more source

Translation regulation in response to stress. [PDF]

FEBS J
Williams TD, Rousseau A.
europepmc   +1 more source

Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities. [PDF]

Acta Pharm Sin B
Wu T, Zhang Y, Han J.
europepmc   +1 more source

Individual genomic loci, transcript level, and biochemical profile of immune and antioxidant markers associated with genetically identified bacterial mastitis in Shami goats in Egypt. [PDF]

Open Vet J
Ebissy E, Darwish A, Hafez AA, Ateya A, El-Sayed A.   +4 more
europepmc   +1 more source

Ribosome dysregulation and intervention in age-related infertility. [PDF]

Cell Rep Med
Li J, Wang H, Zhu P, Chen H, Zuo H, Liu C, Liu L, Ye X, Feng G, Wu Y, Liu Q, Yang T, Keefe DL, Bai X, Shang W, Wu X, Liu L.   +16 more
europepmc   +1 more source

The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury. [PDF]

Adv Virol
Halma M, Vottero P, Thorp J, Peers T, Tuszynski J, Marik P.   +5 more
europepmc   +1 more source

Enhancing PARP inhibitor efficacy in ovarian cancer: targeting the PI3K/AKT/mTOR pathway. [PDF]

J Ovarian Res
Wang Y, Xia Q, Wang X, Lu Y, Wang S, Jiao Y.   +5 more
europepmc   +1 more source