Results 1 to 10 of about 56,302 (135)

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. [PDF]

Protein Sci
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Chatziefthymiou SD, Kuzikov M, Afandi S, Kovacs G, Srivastava S, Zaliani A, Gruzinov A, Pompidor G, Lunelli M, Ahmed GR, Labahn J, Hakanpää J, Windshügel B, Kolbe M.   +13 more
europepmc   +2 more sources

A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation. [PDF]

J Arrhythm
This cross‐tissue transcriptome‐wide association study identified five novel AF susceptibility genes (CAMK2D, SPAST2L, CEP68, FKBP7, and SHRMOO3). Elevated expression of FKBP7, CEP68, and CAMK2D increases AF risk, while SPATS2L shows a protective effect, with colocalization analysis implicating CEP68 and SPATS2L as prioritized candidates.
Yuan Y, Zheng X, Zhang W, Ren Z, Liang B.   +4 more
europepmc   +2 more sources

Short-Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study. [PDF]

Aging Cell
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Cagigas ML, Masedunskas A, Lin Y, Emery-Corbin SJ, Yousef JM, Dagley LF, Olechnowicz S, Bowden R, Hayward R, Low G, Muirhead R, Brand-Miller J, Fogeltholm M, Raben A, Demaria M, Fuller SJ, Fontana L.   +16 more
europepmc   +2 more sources

The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury. [PDF]

Adv Virol
Injury from spike protein, whether induced by COVID‐19 infection or vaccination, constitutes a significant health concern for numerous individuals. Considerable heterogeneity exists in individual responses to both COVID‐19 infection and vaccination, despite the latter being principally more controlled and consistent than the wide variety of infection ...
Halma M, Vottero P, Thorp J, Peers T, Tuszynski J, Marik P.   +5 more
europepmc   +2 more sources

Quality Management of Frontier, Outermost and Disadvantaged Schools in Improving Achievement In Junior Secondary Schools

Al-Fikru, 2023
This study aims to analyze the quality management of frontier, outermost and disadvantaged schools in improving school achievement, the focus of research on planning, implementation, organization, and evaluation.
Ririn Angreany, Husnul Madihah, Didi Susanto   +2 more
doaj   +1 more source

Implementasi Kebijakan Kurikulum dalam Peningkatan Mutu Lulusan di MIN se-Kota Sibolga

Al-Fikru, 2022
This study aims to analyze (1) the implementation of the curriculum in improving the quality of graduates, (2) the strategy of teacher development in implementing the curriculum in improving the quality of graduates, and (3) the factors supporting and ...
Muhammad Rifai Harahap, Mhd. Syahdan Lubis, Syafaruddin Syafaruddin, Makmur Syukri   +3 more
doaj   +1 more source

Analisis Kriteria Nasabah Mampu terhadap Penerapan Sanksi Wanprestasi pada Produk Pembiayaan KPR Syariah (Studi Kasus pada Bank BSI dan BCA Syariah Kantor Cabang Solo)

Al-Fikru, 2022
This study aims to determine (1) the criteria for Bank BSI and BCA Syariah Solo Branch Offices in determining default customers on Sharia mortgage financing products are said to be capable or unable, (2) application of sanctions for defaulting customers
Pamella Puritiara Endriasari, Muh Nashirudin   +1 more
doaj   +1 more source

Menyatukan Hukum Islam dan Adat Jawa Atas Harta Waris Bagi Anak Angkat

Al-Fikru, 2021
The status of adopted children in Islamic law and Javanese customs is still an interesting phenomenon to be studied in Islamic studies, especially to know the legal consequences of two dimensions, namely Islamic law and Javanese customs.
Ade Irma
doaj   +1 more source

Manajemen Finansial Pendidikan di Indonesia (Diskursus Sistem Perpajakan pada Institusi Pendidikan)

Al-Fikru, 2021
This study aims to analyze the Education Financing System in Indonesia and its relation to the tax system. The research method used in this research is qualitative by using a library research approach (library research).
Mesiono Mesiono, Rahmat Rifai Lubis
doaj   +1 more source

Ideologi dan Spirit Sistem Pendidikan Tinggi Islam Indonesia Era Industri 4.0 dan Relevansinya dengan Pencegahan Radikalisme

Al-Fikru, 2021
Penelitian ini bertujuan untuk menganalisis konsep ideologi dan spirit model sistem pendidikan tinggi Islam di Indonesia pada Era Industri 4.0. Metode penelitian yang digunakan ialah library research dengan sumber data utama Undang-undang No.
Mustopa Mustopa, Hisam Ahyani, Ahmad Hapidin   +2 more
doaj   +1 more source