Results 11 to 20 of about 221,370 (152)

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. [PDF]

open access: yesProtein Sci
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Chatziefthymiou SD   +13 more
europepmc   +2 more sources

Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects. [PDF]

open access: yesAdv Sci (Weinh)
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Xu F   +6 more
europepmc   +2 more sources

Ideological Tendencies in the Six English Qur’an Translation on Qs. Ar-Rum 41

open access: yesJurnal Studi Ilmu-ilmu Al-Qur'an dan Hadis, 2021
Lessons from the Qur’an can be learned from its translation by those who do not understand Arabic, although the Qur’an does not state the meaning obviously.
Afif Suaidi, Moh Nur Arifin
doaj   +1 more source

PROGRESIVE QUR’ANIC STUDIES IN INDONESIAN STATE ISLAMIC HIGHER EDUCATION (2014-2019): IMPLEMENTATION AND DEVELOPMENT

open access: yesJurnal Studi Ilmu-ilmu Al-Qur'an dan Hadis, 2021
This article describes the state of progressive Qur'anic interpretation studies over the past five years at three State Islamic Higher Education, UIN Ar-Raniry Banda Aceh, UIN Imam Bonjol Padang and UIN Sultan Syarif Kasim Riau.
Maizuddin Maizuddin   +1 more
doaj   +1 more source

Counter Discourse on the Idea of Islamic State and Formalization of Religion in the Qur’anic Exegesis of KH. Abdurahman Wahid

open access: yesJurnal Studi Ilmu-ilmu Al-Qur'an dan Hadis, 2021
This research discusses KH Abdurrahman Wahid’s Qur’anic interpretation written in his articles around the 2002–2003 period. Initial studies of the text show that Gus Dur was only active in elaborating the Qur’anic verses in his articles after he stepped ...
Ahmad Ahnaf Rafif
doaj   +1 more source

Cadar and Women’s Awrat In Indonesian Qur'an Literature

open access: yesJurnal Studi Ilmu-ilmu Al-Qur'an dan Hadis, 2021
The use of cadar becomes a controversial discussion in Indonesia. However, the majority of scholars consider the cadar is not an obligation in religion. Bearing in mind, there are differences in the limits of women's genitalia or awrat.
Indal Abror   +3 more
doaj   +1 more source

A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation. [PDF]

open access: yesJ Arrhythm
This cross‐tissue transcriptome‐wide association study identified five novel AF susceptibility genes (CAMK2D, SPAST2L, CEP68, FKBP7, and SHRMOO3). Elevated expression of FKBP7, CEP68, and CAMK2D increases AF risk, while SPATS2L shows a protective effect, with colocalization analysis implicating CEP68 and SPATS2L as prioritized candidates.
Yuan Y   +4 more
europepmc   +2 more sources

Buka Luwur as A Media of Education and Social Solidarity of Kudus Community

open access: yesAl-Tahrir, 2019
: Buka Luwur is an annual ritual that has become a tradition of Kudus community. It is a moment of respecting Kanjeng Sunan Kudus by providing some meal.
Irzum Farihah, Ismanto Ismanto
doaj   +1 more source

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]

open access: yes, 2009
The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Kanako Kuwasako   +27 more
core   +2 more sources

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