Results 11 to 20 of about 243,792 (206)

15q11.2 BP1-BP2 microdeletion presenting as progressive spastic paraplegia and brain images of small vessel disease [PDF]

Neurosciences (Riyadh), 2022
15q11.2 BP1-BP2 microdeletion is related to clinical abnormalities including general developmental delay, speech and neuropsychiatric disorders, which is known as Angelman syndrome.
Sha Q, Xia Y, Shen X, Du A.
europepmc   +2 more sources

C-253 INNOVACIÓN E INVESTIGACIÓN, IMPRESCINDIBLES PARA EL DESARROLLO DE LAS NACIONES

, 2014
C-253 INNOVACIÓN E INVESTIGACIÓN, IMPRESCINDIBLES PARA EL DESARROLLO DE LAS NACIONESC-253 INNOVACIÓN E INVESTIGACIÓN, IMPRESCINDIBLES PARA EL DESARROLLO DE LAS ...
Coordinación de Comunicación Social, Imágenes
core   +20 more sources

The expression and significance of p4E‐BP1/4E‐BP1 in prostate cancer

Journal of Clinical Laboratory Analysis, 2022
Although the phosphorylation of 4E‐BP1 that has been detected in high‐grade prostate cancer has been reported in previous studies, overexpression of p4E‐BP1 and 4EBP1 and their clinical significance in prostate cancer still remain unknown.
Ke-Jie Wang, Qi Ma
exaly   +2 more sources

Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression

Genome Biology
Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing ...
G. Tang, Haoxue Xia, Yufei Huang, Yuanwen Guo, Yun Chen, Zhonghua Ma, Wende Liu   +6 more
semanticscholar   +2 more sources

4E-BP1 is a tumor suppressor protein reactivated by mTOR inhibition in head and neck cancer [PDF]

Cancer Research, 2019
Aberrant activation of the PI3K-mTOR signaling pathway occurs in >80% of head and neck squamous cell carcinomas (HNSCC), and overreliance on this signaling circuit may in turn represent a cancer-specific vulnerability that can be exploited ...
Zhiyong Wang, Xiaodong Feng, A. Molinolo, Daniel Martin, L. Vitale-Cross, N. Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, M. Gilardi, M. Allevato, Victoria H. Wu, Dana J. Steffen, P. Tofilon, N. Sonenberg, J. Califano, Qianming Chen, S. Lippman, J. Gutkind   +19 more
semanticscholar   +2 more sources

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. [PDF]

Protein Sci
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Chatziefthymiou SD, Kuzikov M, Afandi S, Kovacs G, Srivastava S, Zaliani A, Gruzinov A, Pompidor G, Lunelli M, Ahmed GR, Labahn J, Hakanpää J, Windshügel B, Kolbe M.   +13 more
europepmc   +2 more sources

Prader–Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review

International Journal of Molecular Sciences, 2023
Prader–Willi syndrome (PWS) is a complex genetic disorder with three PWS molecular genetic classes and presents as severe hypotonia, failure to thrive, hypogonadism/hypogenitalism and developmental delay during infancy. Hyperphagia, obesity, learning and
M. Butler
semanticscholar   +1 more source

SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1

Journal of Biological Chemistry, 2023
Breast cancer stem cells are mainly responsible for poor prognosis, especially in triple-negative breast cancer (TNBC). In a previous study, we demonstrated that ε-Sarcoglycan (SGCE), a type Ⅰ single-transmembrane protein, is a potential oncogene that ...
Ting Qiu, Lei Hou, Lina Zhao, Xinye Wang, Zhongmei Zhou, Chuanyu Yang, Huifeng Zhang, Dewei Jiang, B. Jiao, Ceshi Chen   +9 more
semanticscholar   +1 more source

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.

Molecules and Cells, 2021
The activation of cap-dependent translation in eukaryotes requires multisite, hierarchical phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 (mTORC1). To resolve the mechanism of this hierarchical phosphorylation at the
R. Böhm, S. Imseng, R. Jakob, M. Hall, T. Maier, S. Hiller   +5 more
semanticscholar   +1 more source

4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis

Protein & Cell, 2022
Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown.
Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, J. Qu   +12 more
semanticscholar   +1 more source