Results 41 to 50 of about 2,127,287 (180)

Functions of double-stranded RNA-binding domains in nucleocytoplasmic transport [PDF]

, 2014
International audienceThe double-stranded RNA-binding domain (dsRBD) is a small protein domain found in eukaryotic, prokaryotic and viral proteins, whose central property is to bind to double-stranded RNA (dsRNA).
Barraud, Pierre, Banerjee, Silpi
core   +1 more source

Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast

Cell Reports, 2018
Summary: In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during “open” mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are “closed,” during which the NE is maintained ...
Ignacio Flor-Parra, Ana Belén Iglesias-Romero, Silvia Salas-Pino, Rafael Lucena, Juan Jimenez, Rafael R. Daga   +5 more
doaj   +1 more source

Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors

Biology, 2022
RNA-binding proteins (RBPs) with a low-complexity prion-like domain (PLD) can undergo aberrant phase transitions and have been implicated in neurodegenerative diseases such as ALS and FTD.
Amandeep Girdhar, Lin Guo
doaj   +1 more source

Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers. [PDF]

J Cell Sci
Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single adhesive cells, mechanotransduction involves the transmission of force from the extracellular matrix to the cell nucleus,
Granero-Moya I, Venturini V, Belthier G, Groenen B, Molina-Jordán M, González-Martín M, Trepat X, van Rheenen J, Andreu I, Roca-Cusachs P.   +9 more
europepmc   +2 more sources

Nucleocytoplasmic transport in apoptosis

, 2005
The apoptotic demolition of the nucleus is accomplished by diverse proapoptotic factors, most of which are activated in the cytoplasm and gain access to the nucleoplasm during the cell death process.
E Ferrando-May, Ferrando-May, Elisa
core   +1 more source

Nucleocytoplasmic transport: factors and mechanisms [PDF]

, 1995
In the past two years, our knowledge concerning the mechanisms of nucleocytoplasmic transport through the nuclear pore complex (NPC) has considerably expanded.
George Simos, Eduard C. Hurt, Hurt, Eduard C., Simos, George   +3 more
core   +1 more source

Nuclear pore dysfunction and disease: a complex opportunity

Nucleus
The separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including
Charlotte M. Fare, Jeffrey D. Rothstein
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Nucleocytoplasmic transport: Driving and directing transport

, 1998
Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran.
Cole, C. N., Hammell, C. M.
core   +1 more source

Meeting society's transport needs under tight budgets [PDF]

, 2011
In the aftermath of the 2008 financial crisis, both the private and public sectors face stringent constraints in funding for transport infrastructure investment and transport services.
International Transport Forum, OECD
core   +1 more source