Results 41 to 50 of about 15,740 (146)
Mechanosensitivity of nucleocytoplasmic transport [PDF]
, 2021 Abstract Mechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses applied forces. Here we show that nuclear forces differentially control passive and facilitated nucleocytoplasmic transport, setting the rules for the mechanosensitivity of ...
Ion Andreu +9 more
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Calcium regulation of nucleocytoplasmic transport [PDF]
Protein & Cell, 2011 Bidirectional trafficking of macromolecules between the cytoplasm and the nucleus is mediated by the nuclear pore complexes (NPCs) embedded in the nuclear envelope (NE) of eukaryotic cell. The NPC functions as the sole pathway to allow for the passive diffusion of small molecules and the facilitated translocation of larger molecules.
Ashapurna, Sarma, Weidong, Yang
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Analysis of Potential Nucleocytoplasmic Shuttling Mechanisms of the Machado-Joseph Disease Protein, Ataxin-3 [PDF]
, 2006 Supplementary Information Video attached Machado-Joseph disease (MJD), also known as Spinocerebellar ataxia type 3 (SCA3) is one of nine poly glutamine neurodegenerative diseases caused by an expansion of CAG DNA triplets in the genes resulting in an ...
Pinchev, Deborah
core
Multiscale dynamics in nucleocytoplasmic transport [PDF]
Current Opinion in Cell Biology, 2012 The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete interaction sites outside the central
David, Grünwald, Robert H, Singer
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, 2009 The degradation of nuclear pore components and disruption of nucleocytoplasmic trafficking during rhinovirus infection have been attributed to viral 2A protease.
D. Li +18 more
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Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration
, 2020 Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Van Damme, Philip +4 more
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Nucleocytoplasmic transport : signals, mechanisms and regulation
, 1997 In eukaryotic organisms, DNA replication and RNA biogenesis occur in the cell nucleus, whereas protein synthesis occurs in the cytoplasm. Integration of these activities depends on selective transport of proteins and ribonucleoprotein particles between ...
Erich A. Nigg +2 more
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Functions of double-stranded RNA-binding domains in nucleocytoplasmic transport
, 2014 International audienceThe double-stranded RNA-binding domain (dsRBD) is a small protein domain found in eukaryotic, prokaryotic and viral proteins, whose central property is to bind to double-stranded RNA (dsRNA).
Barraud, Pierre, Banerjee, Silpi
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Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport [PDF]
, 2017 Onset of neurodegenerative disorders, including Huntington's disease, is strongly influenced by aging. Hallmarks of aged cells include compromised nuclear envelope integrity, impaired nucleocytoplasmic transport, and accumulation of DNA double-strand ...
Fatima Gasset-Rosa +19 more
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, 2021 The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah +2 more
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