Results 31 to 40 of about 14,540 (195)

Nucleocytoplasmic transport: Driving and directing transport [PDF]

Current Biology, 1998
Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.
Cole, Charles N, Hammell, Christopher M
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NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase [PDF]

Annual Review of Biochemistry, 1998
Active transport between the nucleus and cytoplasm involves primarily three classes of macromolecules: substrates, adaptors, and receptors. Some transport substrates bind directly to an import or an export receptor while others require one or more adaptors to mediate formation of a receptor-substrate complex.
I W, Mattaj, L, Englmeier
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RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity

Cell Reports, 2018
Summary: Neuronal polarity in the developing cortex begins during the early stages of neural progenitor migration toward the cortical plate and culminates with the specification of the axon and dendrites.
Chiara Mencarelli, Justyna Nitarska, Tim Kroecher, Francesco Ferraro, Katherine Massey, Antonella Riccio, Franck Pichaud   +6 more
doaj   +1 more source

Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae

BMC Molecular and Cell Biology, 2022
Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier, Karyn G. Belanger   +8 more
doaj   +1 more source

C9orf72 Toxic Species Affect ArfGAP-1 Function

Cells, 2023
Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi, Michela Di Salvio, Marilisa Balì, Assia De Simone, Savina Apolloni, Nadia D’Ambrosi, Ivan Arisi, Francesca Cipressa, Mauro Cozzolino, Gianluca Cestra   +9 more
doaj   +1 more source

Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer

Heliyon, 2021
Transport of functional molecules across the nuclear membrane of a eukaryotic cell is regulated by a dedicated set of transporter proteins that carry molecules into the nucleus or out of the nucleus to the cytoplasm for homeostasis of the cell.
Rashid Mehmood, Kazuya Jibiki, Noriko Shibazaki, Noriko Yasuhara   +3 more
doaj   +1 more source

The functions of herpesvirus shuttling proteins in the virus lifecycle

Frontiers in Microbiology
During viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually ...
Huijun Cao, Huijun Cao, Huijun Cao, Huijun Cao, Huijun Cao, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Di Sun, Yu He, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, YanLing Yu, Ling Zhang, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia   +85 more
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Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis. [PDF]

PLoS ONE, 2017
Aberrant nucleocytoplasmic localization of proteins has been implicated in many neurodegenerative diseases. Evidence suggests that cytoplasmic mislocalization of nuclear proteins such as transactive response DNA-binding protein 43 (TDP-43) and fused in ...
Jee-Eun Kim, Yoon Ho Hong, Jin Young Kim, Gye Sun Jeon, Jung Hee Jung, Byung-Nam Yoon, Sung-Yeon Son, Kwang-Woo Lee, Jong-Il Kim, Jung-Joon Sung   +9 more
doaj   +1 more source

A Review of the Role of Shuttling Proteins in Herpesvirus Replication and Pathogenesis

Al-Kitab Journal for Pure Sciences
 Herpesviruses are complex DNA viruses that rely on host-cell machinery for replication and pathogenesis. One critical aspect of their lifecycle involves the transport of viral and host proteins between the nucleus and cytoplasm.
Ayam Mohammed Salih
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Mechanosensitivity of nucleocytoplasmic transport [PDF]

, 2021
Abstract Mechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses applied forces. Here we show that nuclear forces differentially control passive and facilitated nucleocytoplasmic transport, setting the rules for the mechanosensitivity of ...
Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina Jordàn, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Barak Raveh, Pere Roca-Cusachs   +9 more
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