Results 31 to 40 of about 2,127,287 (180)

RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity

Cell Reports, 2018
Summary: Neuronal polarity in the developing cortex begins during the early stages of neural progenitor migration toward the cortical plate and culminates with the specification of the axon and dendrites.
Chiara Mencarelli, Justyna Nitarska, Tim Kroecher, Francesco Ferraro, Katherine Massey, Antonella Riccio, Franck Pichaud   +6 more
doaj   +1 more source

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport [PDF]

, 2015
An unbiased genetic screen in Drosophila expressing G4C2-repeat-containing transcripts (repeats that in human cause pathogenesis in C9orf72-related neurological disease) finds genes that encode components of the nuclear pore and nucleocytoplasmic ...
Wong, Philip C, Kyung-Ha Lee, Rodrigo Lopez-Gonzalez, Hong Joo Kim, Yubing Lu, Almeida, Sandra, Brian D. Freibaum, Lu, Yubing, Lee, Kyung-Ha, Fen-Biao Gao, Miller, Bruce L, Valentine, Marc, J. Paul Taylor, Sandra Almeida, Badders, Nisha, Kim, Hong Joo, Leonard Petrucelli, Nam Chul Kim, Philip C. Wong, Kim, Nam Chul, Bruce L. Miller, Gao, Fen-Biao, Taylor, J Paul, Lopez-Gonzalez, Rodrigo, Petrucelli, Leonard, Nisha Badders, Freibaum, Brian D, Marc Valentine   +27 more
core   +1 more source

Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae

BMC Molecular and Cell Biology, 2022
Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier, Karyn G. Belanger   +8 more
doaj   +1 more source

C9orf72 Toxic Species Affect ArfGAP-1 Function

Cells, 2023
Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi, Michela Di Salvio, Marilisa Balì, Assia De Simone, Savina Apolloni, Nadia D’Ambrosi, Ivan Arisi, Francesca Cipressa, Mauro Cozzolino, Gianluca Cestra   +9 more
doaj   +1 more source

Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer

Heliyon, 2021
Transport of functional molecules across the nuclear membrane of a eukaryotic cell is regulated by a dedicated set of transporter proteins that carry molecules into the nucleus or out of the nucleus to the cytoplasm for homeostasis of the cell.
Rashid Mehmood, Kazuya Jibiki, Noriko Shibazaki, Noriko Yasuhara   +3 more
doaj   +1 more source

The functions of herpesvirus shuttling proteins in the virus lifecycle

Frontiers in Microbiology
During viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually ...
Huijun Cao, Huijun Cao, Huijun Cao, Huijun Cao, Huijun Cao, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Di Sun, Yu He, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, YanLing Yu, Ling Zhang, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia   +85 more
doaj   +1 more source

Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis. [PDF]

PLoS ONE, 2017
Aberrant nucleocytoplasmic localization of proteins has been implicated in many neurodegenerative diseases. Evidence suggests that cytoplasmic mislocalization of nuclear proteins such as transactive response DNA-binding protein 43 (TDP-43) and fused in ...
Jee-Eun Kim, Yoon Ho Hong, Jin Young Kim, Gye Sun Jeon, Jung Hee Jung, Byung-Nam Yoon, Sung-Yeon Son, Kwang-Woo Lee, Jong-Il Kim, Jung-Joon Sung   +9 more
doaj   +1 more source

Structural and Biochemical Studies of the Human DEAD-box Helicase Dbp5 and Nucleoporin Nup214 Involved in mRNA Export [PDF]

, 2009
The hallmark of eukaryotic evolution was the development of the nucleus in cells. This compartmentalization requires the nucleocytoplasmic transport of thousands of molecules. The gate into and out of the nucleus is the nuclear pore complex (NPC). One of
Moeller, Holger von, Moeller, H.
core   +1 more source

A Review of the Role of Shuttling Proteins in Herpesvirus Replication and Pathogenesis

Al-Kitab Journal for Pure Sciences
 Herpesviruses are complex DNA viruses that rely on host-cell machinery for replication and pathogenesis. One critical aspect of their lifecycle involves the transport of viral and host proteins between the nucleus and cytoplasm.
Ayam Mohammed Salih
doaj   +1 more source

Transport outlook 2009: Globalisation, crisis and transport [PDF]

, 2009
This second ITF Transport Outlook continues building towards a full-fledged Transport Outlook, building upon the first Outlook (JTRC, 20081). The 2008 Outlook investigated the relation between expected GDP evolution and the demand for road transport ...
International Transport Forum, OECD
core   +1 more source