Results 31 to 40 of about 27,476 (204)
Diversification of importin-α isoforms in cellular trafficking and disease states. [PDF]
, 2015 The human genome encodes seven isoforms of importin α which are grouped into three subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved architecture that consists of an N-terminal, autoinhibitory, importin-β-binding (IBB ...
Ahluwalia +221 more
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Nucleocytoplasmic transport: Driving and directing transport [PDF]
Current Biology, 1998 Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.
Cole, Charles N, Hammell, Christopher M
openaire +2 more sources
Frontiers in Microbiology, 2015 The respiratory diseases caused by Rhinovirus, Respiratory Syncytial Virus and Influenza virus represent a large social and financial burden on healthcare worldwide.
Leon eCaly +2 more
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An agent-based model for mRNA export through the nuclear pore complex. [PDF]
, 2014 mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad +3 more
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OsEUL lectin gene expression in rice : stress regulation, subcellular localization and tissue specificity [PDF]
, 2020 The Euonymus lectin (EUL) family is a unique group of carbohydrate-binding proteins that is omnipresent in plants. Sequences encoding EUL-related lectins have been retrieved from all completely sequenced plant genomes.
De Zaeytijd, Jeroen +9 more
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Role of molecular charge in nucleocytoplasmic transport. [PDF]
PLoS ONE, 2014 Transport of genetic materials and proteins between the nucleus and cytoplasm of eukaryotic cells is mediated by nuclear pore complexes (NPCs). A selective barrier formed by phenylalanine-glycine (FG) nucleoporins (Nups) with net positive charges in the ...
Alexander Goryaynov, Weidong Yang
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Efficiency, selectivity, and robustness of nucleocytoplasmic transport. [PDF]
PLoS Computational Biology, 2007 All materials enter or exit the cell nucleus through nuclear pore complexes (NPCs), efficient transport devices that combine high selectivity and throughput. NPC-associated proteins containing phenylalanine-glycine repeats (FG nups) have large, flexible,
Anton Zilman +4 more
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Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]
, 2015 Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean +5 more
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Nucleocytoplasmic Transport: Navigating the Channel [PDF]
Traffic, 2003 Nucleocytoplasmic transport is mediated by shuttling receptors that recognize specific signals on protein or RNA cargoes and translocate the cargoes through the nuclear pore complex. Transport receptors appear to move through the nuclear pore complex by facilitated diffusion, involving repeated cycles of binding to and dissociation from nucleoporins ...
Janna, Bednenko +2 more
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RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity
Cell Reports, 2018 Summary: Neuronal polarity in the developing cortex begins during the early stages of neural progenitor migration toward the cortical plate and culminates with the specification of the axon and dendrites.
Chiara Mencarelli +6 more
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